Cyclic nucleotide signaling / edited by Xiaodong Cheng.

Format:

Book

Contributor:

Cheng, Xiaodong, editor.

Series:

Methods in signal transduction.

Methods in Signal Transduction Series

Language:

English

Subjects (All):

Cyclic nucleotides.

Physical Description:

1 online resource (282 p.)

Edition:

1st ed.

Place of Publication:

Boca Raton, Florida : CRC Press, [2015]

Language Note:

English

Summary:

<P>Showcasing the recent progresses of the field, <B>Cyclic Nucleotide Signaling<I> </B></I>covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.</P>

Contents:

Front Cover; Contents; Series Preface; Preface; Editor; Contributors; Chapter 1: Discovery of Small Molecule EPAC Specific Modulators by High-Throughput Screening; Chapter 2: Cyclic Nucleotide Analogs as Pharmacological Tools for Studying Signaling Pathways; Chapter 3: High-Throughput FRET Assays for Fast Time-Dependent Detection of Cyclic AMP in Pancreatic β Cells; Chapter 4: Assessing Cyclic Nucleotide Recognition in Cells : Opportunities and Pitfalls for Selective Receptor Activation; Chapter 5: Monitoring Cyclic Nucleotides Using Genetically Encoded Fluorescent Reporters

Chapter 6: Structural Characterization of Epac by X-Ray CrystallographyChapter 7: Sensory Neuron cAMP Signaling in Chronic Pain; Chapter 8: Monitoring Real-Time Cyclic Nucleotide Dynamics in Subcellular Microdomains; Chapter 9: Identifying Complexes of Adenylyl Cyclase with A-Kinase Anchoring Proteins; Chapter 10: Assessing Cyclic Nucleotide Binding Domain Allostery and Dynamics by NMR Spectroscopy; Chapter 11: A Protocol for Expression and Purification of Cyclic Nucleotide-Free Protein in Escherichia coli; Chapter 12: Cyclic Nucleotide Analogues as Chemical Tools for Interaction Analysis

Chapter 13: Dissecting the Physiological Functions of PKA Using Genetically Modified MiceBack Cover

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters.

Description based on online resource; title from PDF title page (ebrary, viewed May 30, 2015).

ISBN:

9781040212790

1040212794

9780429161926

0429161921

9781482235579

1482235579

OCLC:

908931921