Macropinocytosis : Functions and Mechanisms / edited by Cosimo Commisso.

Format:

Book

Contributor:

Commisso, Cosimo, editor.

Series:

Subcellular Biochemistry, 2542-8810 ; 98

Language:

English

Subjects (All):

Cytology.

Biophysics.

Cell interaction.

Biological transport.

Cell membranes.

Medicine--Research.

Medicine.

Biology--Research.

Biology.

Cell Biology.

Mechanobiological Cell Signaling.

Membrane Trafficking.

Biomedical Research.

Local Subjects:

Cell Biology.

Mechanobiological Cell Signaling.

Membrane Trafficking.

Biomedical Research.

Physical Description:

1 online resource (227 pages)

Edition:

1st ed. 2022.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2022.

Summary:

This book presents the functions and mechanisms of macropinocytosis, an actin-driven endocytic uptake process. Key points, including the evolutionary origins of macropinocytosis and major signaling pathways that regulate this uptake mechanism, are highlighted. A wide-array of functions of macropinocytosis are described, including cellular metabolism, cell death, cell migration and antigen presentation. Macropinocytosis has recently been recognized as a critical pathway in disease pathology and treatment. Therefore, a broad overview of macropinocytosis will benefit clinicians, as well as translational and basic research scientists. Moreover, as one of the main clathrin-independent endocytic routes, compiling all the critical information about macropinocytosis in one collection, this book will also be helpful to educators and their students.

Contents:

Part 1: Functions of Macropinocytosis

Chapter 1: Functional Diversity of Macropinocytosis

Chapter 2: Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways

Chapter 3: The amoebal model for micropinocytosis

Chapter 4: Extracellular ATP and macropinocytosis

Chapter 5: Macropinocytosis and Cell Migration: Don't drink an drive

Chapter 6: Macropinocytosis in phagocyte function and immunity

Part 2: Signaling Mechanisms Driving Macropinocytosis

Chapter 7: Roles of 3' Phosphoinositides in Macropinocytosis

Chapter 8: Signaling pathways that regulate macropinocytosis in mammalian cells

Chapter 9: Wnt, GSK3 and Macropinocytosis

Chapter 10: Kras addiction promotes cancer cell adapation in harsh microenvironment through micropinocytosis

Chapter 11: Kras-independent macropinocytosis in pancreatic cancer.

Notes:

Includes index.

Other Format:

Print version: Commisso, Cosimo Macropinocytosis

ISBN:

9783030940041