G Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators

Format:

Book

Author/Creator:

Hattori, Yuichi, Editor.

Contributor:

Michel, Martin C., Editor.

Hattori, Yuichi

Michel, Martin C.

Language:

English

Physical Description:

1 online resource (182 p.)

Other Title:

G Protein-Coupled Receptor Kinases

Place of Publication:

Frontiers Media SA 2020

Language Note:

English

Summary:

G protein-coupled receptor kinases (GRKs) and arrestins were initially identified as a pivotal player in the process of desensitization of agonist-activated G protein-coupled receptors (GPCRs). However, growing evidence suggests GRKs and arrestins fulfill a vital role in regulating a variety of cellular proteins involved in signal transduction independently of GPCRs. Thus, GRKs and arrestins can interact with non-GPCRs. GRKs and arrestins may directly affect functioning of non-GPCRs or indirectly regulate non-GPCR signaling. In addition, emerging evidence supports that changes in function and/or expression of GRKs and arrestins may be important in cardiovascular, inflammatory, metabolic, or cancer pathologies. A better understanding of the pathological roles of GRKs and arrestins would provide a basis for new therapeutic targets in different human diseases.