Translational research in breast cancer / Dong-Young Noh, Wonshik Han, Masakazu Toi, editors.

Format:

Book

Contributor:

Han, Wonshik, editor.

Toi, Masakazu, editor.

Noh, Dong-Young, editor.

Series:

Advances in experimental medicine and biology ; Volume 1187.

Advances in experimental medicine and biology ; Volume 1187

Language:

English

Subjects (All):

Breast--Cancer--Research.

Breast.

Physical Description:

1 online resource (IX, 630 p. 122 illus., 99 illus. in color.)

Edition:

1st ed. 2021.

Place of Publication:

Singapore : Springer, [2021]

Summary:

This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.

Contents:

Part I. Introduction

Chapter 1. Translational Research in Surgical Oncology: Introduction and My Own Experience as a Surgeon-Scientist

Part II. Breast Cancer Biology and Cell Signaling Pathways

Chapter 2. Phospholipase Signaling in Breast Cancer

Chapter 3. HER2 Signaling in Breast Cancer

Chapter 4. Ras Signaling in Breast Cancer

Chapter 5. Epigenetic Regulation in Breast Cancer

Chapter 6. Role of tRNAs in Breast Cancer Regulation

Chapter 7. Fusion Genes in Breast Cancer

Chapter 8. DNA Damage Repair Inhibitor for Breast Cancer Treatment

Part III. Cancer Stem Cell and Tumor Heterogeneity in Breast Cancer

Chapter 9. Breast Cancer Metastasis

Chapter 10. Single Cell Genomics for Tumor Heterogeneity

Chapter 11. Advances in Tumor Sampling and Sequencing in Breast Cancer and their Application in Precision Diagnostics and Therapeutics

Chapter 12. Cancer Stem Cell in Immune Microenvironment

Chapter 13. Theranostics for Breast Cancer Stem Cells

Chapter 14. Patient-Derived Xenograft Models in Breast Cancer Research

Part IV Biomarkers for Precision Medicine in Breast Cancer Patients

Chapter 15. Proteomic Interrogation in Cancer Biomarker

Chapter 16. Next-Generation Sequencing-Based Biomarkers in Breast Cancer

Chapter 17. Liquid Biopsy in Breast Cancer: Circulating Tumor Cells and Circulating Tumor DNA

Chapter 18. Current Biomarkers for Precision Medicine in Breast Cancer

Chapter 19. The Potential Predictors in Chemotherapy Sensitivity

Chapter 20. Hormone Resistance

Part V. Managing High Risk Women

Chapter 21. High-Risk Population Based on BC Risk Factors

Chapter 22. Breast Cancer-Related Low Penetrance Genes

Chapter 23. Rare Coding Variants Associated with Breast Cancer

Chapter 24. Multigene Panel Testing for Hereditary Cancer and Genetic Counseling

Chapter 25. BRCA and Breast Cancer-Related High-Penetrance Genes

Part VI. Next Generation Clinical Research

Chapter 26. Clinical Databases for Breast Cancer Research

Chapter 27. Care for Breast Cancer Survivors

Chapter 28. Considerations in Oncoplastic Surgery

Chapter 29. Diet Before and After Breast Cancer

Chapter 30. Current Trends in and Indications for Endoscopy-Assisted Breast Surgery for Breast Cancer

Chapter 31. Minimal Invasive and Individualizing Management of the Axillary Nodes

Chapter 32. Malignant Phyllodes of Breast

Chapter 33. Next-Generation Clinical Trials and Research with Successful Collaborations

Part VII. Epilogue

Chapter 34. Transformation of the Patient and Society: A Patient Survivors’ Group and Breast Cancer Awareness Campaign.

Notes:

Description based on print version record.

ISBN:

981-329-620-8

OCLC:

1251911217