Cell Biology and Translational Medicine, Volume 11 : Stem Cell Therapy - Potential and Challenges.

Format:

Book

Author/Creator:

Turksen, Kursad.

Series:

Advances in Experimental Medicine and Biology

Advances in Experimental Medicine and Biology ; v.1312

Language:

English

Physical Description:

1 online resource (182 pages)

Edition:

1st ed.

Other Title:

Cell Biology and Translational Medicine, Volume 11

Place of Publication:

Cham : Springer International Publishing AG, 2021.

System Details:

Mode of access: World Wide Web.

Summary:

Much research has focused on the basic cellular and molecular biological aspects of stem cells.Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies.

Contents:

Intro

Preface

Contents

Induced Pluripotent Stem Cell Derived Human Lung Organoids to Map and Treat the SARS-CoV2 Infections In Vitro

1 Introduction

2 History of Virus Transmitted Infections and Respiratory Tract Infections -Early Days Till Date with an Understanding of Glob...

3 Lung Stem Cell Organoids Generated from Induced Pluripotent Stem Cells

4 Strategies for Using Human Lung Organoids from iPSCs of Various Age Groups and Different Ethnicities for Assessing the Infec...

5 Strategies for Using Human Lung Organoids from iPSCs of Different Ethnicities for Antiviral/Repurposed Drug Screening Agains...

6 Conclusions

References

Embryonic Stem Cells in Clinical Trials: Current Overview of Developments and Challenges

2 hESC for Clinical Trials

3 Neurological Disorders

4 Cardiovascular Diseases

5 Diabetes Type I

6 Ophthalmology

7 Immuno-Therapy

8 Guidelines About the Protocols of Using hESC in Basic Studies and Clinical Trials

9 hESC Culture for Clinical Trial Studies

10 Providing a Cell Culture System Free of any Xenobiotics for hESC

11 Genetic Anomalies in hESC Lines

12 Inhibiting Immunity Rejection of Transplantation OF ESC-Derived Cells

13 Advantages of Using ESC Along with Other Stem Cells

14 Outlook and Future Directions

15 Conclusion

Functions of Mesenchymal Stem Cells in Cardiac Repair

2 Mesenchymal Stem Cell Types

3 Mesenchymal Stem Cell Functions

3.1 Differentiation

3.2 Neovascularization

3.3 Anti-fibrotic Effects

3.4 Immune Modulation

4 Paracrine Functions &amp

Extracellular Vesicles

5 Conclusion

Cardiac Progenitor Cells

2 Development of Cardiac Progenitor Cells

2.1 Embryology of the Heart.

2.2 Role of Cardiac Progenitor Cells in Heart Development

3 Types of Cardiac Progenitor Cell

3.1 Cardiac Progenitor Cells in Embryonic Heart

3.1.1 Cardiac Mesoderm Cells

3.1.2 Cardiac Neural Crest Progenitors

3.1.3 Proepicardium (PE)

3.2 Cardiac Progenitor Cells in Adult Heart

3.3 Cardiac Progenitor Cells Derived from Human Pluripotent Stem Cells

4 In Vitro Characterization of Cardiac Progenitor Cells in Embryonic and Adult Heart

5 Concepts in Cardiac Differentiation

6 Clinical Applications of Cardiac Stem Cells

6.1 Pluripotent Stem Cells

6.1.1 Embryonic Stem Cells

6.1.2 Induced Pluripotent Stem Cells (iPSCs)

6.2 Multipotent Stem Cells

6.2.1 Mesenchymal Stem Cells

6.2.2 Cardiac Progenitor Cells

6.2.3 Hematopoietic Stem Cells

6.2.4 Skeletal Myoblasts (Satellite Cells)

Cardiac Immunology: A New Era for Immune Cells in the Heart

1 Introduction to Cardiac Immunology

2 Immune Cells of the Heart

2.1 Neutrophils

2.2 Mast Cells

2.3 Monocyte/Macrophages

Box 1 Immuno-Electrophysiological Roles of Cardiac Macrophages

3 Inflammatory Heart Diseases

Box 2 Inflammatory Marker CRP in Cardiac Disorders

3.1 Endocarditis

3.2 Myocarditis

3.3 Pericarditis

3.4 Rheumatic Fever

3.5 Chagas´ Disease

3.6 Lyme Disease

4 Non-infectious Cardiac Diseases and Immunity

4.1 Myocardial Infarct (MI)

4.2 Atherosclerosis

4.3 Conduction Disorders

4.3.1 Atrial Fibrillation (AF)

4.3.2 Arrhythmia

5 Therapeutic Anti-inflammatory Agents for Cardiac Diseases

6 Conclusion

Conventional and Alternative Mesenchymal Stem Cell Therapies for the Treatment of Diabetes

1.1 Diabetes: A Global Epidemic

1.2 Diabetes Status

2 Non-pharmacological Interventions

3 Pharmacological Diabetes Treatment Options.

4 Alternative Diabetes Therapies

4.1 Preclinical Applications of Mesenchymal Stem Cells in Diabetes

4.2 Clinical Applications of Mesenchymal Stem Cells in Diabetes

Mesenchymal Stem Cells: The Past Present and Future

1 History of MSCs

2 Characterization of MSCs

3 Applications of MSCs

3.1 Cell Therapy

3.1.1 Cell-Based Therapy

3.1.2 Cells as a Gene/Drug Delivery Tool

3.2 Cell-Free Therapy

3.2.1 MSC-Derived Conditioned Media

3.2.2 MSC-Derived Extracellular Vesicles

3.2.3 MSC-Mediated Organelle Transfer

4 Limitations of MSC therapeutics

5 Future Perspectives

Extracellular Vesicle Therapeutics in Regenerative Medicine

2 Stem Cells-Derived EVs

2.1 MSCs-EVs

2.2 Induced Pluripotent- and Embryonic Stem Cell-Derived EVs

3 Progenitor Cell- and Differentiated Cell- Derived EVs

4 Milk and Plant-Derived EVs

5 Drug-Loaded EVs

6 Hurdles to Consider for Clinical Application of EVs Therapeutics

6.1 Production of Large-Scale EVs

6.2 Isolation of Pure and Uniform EVs

6.3 Optimization of Storage Conditions of EVs

6.4 Optimization of Administration of EVs

7 Conclusions

Exosomes as Part of the Human Adipose-Derived Stem Cells Secretome- Opening New Perspectives for Cell-Free Regenerative Applic...

2 Exosomes and Their Potential for Tissue Regeneration

3 hASC-Exos Interaction with the Signaling Pathways Involved in Tissue Regeneration

3.1 hASC-Exos Interaction with Wnt-β Catenin Pathway

3.2 hASC-Exos Interaction with PI3K-Akt Pathway

3.3 Other Signaling Pathways Involved in Regenerative Properties of hASC-Exos

4 Biological Functions of hASC-Exos and Contribution to Tissue Regeneration

4.1 hASC-Exos Function in Immunomodulation and Anti-Inflammatory Activity.

4.1.1 Anti-inflammatory miRNAs Specific to hASCs-Exos and Their Effects

4.2 hASC-Exos Effect on Cell Growth, Proliferation and Differentiation

4.3 hASC-Exos Involvement in Angiogenesis

4.4 hASC-Exos Influence on Matrix Remodeling

4.5 Anti-apoptotic Signals Mediated by hASC-Exos

5 Conclusions

A Museum of Stem Cells Points to Muse Cells as Robust Transplantable Cells for Stroke: Review

2 Identifying the Optimal Cell Type for Stem Cell Transplantation

2.1 Embryonic Stem Cells

2.2 Neural Stem Cells

2.3 Induced Pluripotent Stem Cells

2.4 Other Sources of Adult Stem Cells

2.5 Bone Marrow-Derived Stem Cells

2.6 Mesenchymal Stem Cells

2.7 Multilineage-Differentiating Stress Enduring (Muse) Cells

3 Preclinical Studies on Muse Cells

4 Clinical Studies on Muse Cells

5 Summary

Index.

Notes:

Includes bibliographical references and index.

Description based on publisher supplied metadata and other sources.

ISBN:

3-030-71925-1

OCLC:

1261367365