Ferroptosis : mechanism and diseases / Andrés F. Florez, Hamed Alborzinia, editors.

Format:

Book

Contributor:

Florez, Andrés F., editor.

Alborzinia, Hamed, editor.

Series:

Advances in experimental medicine and biology ; Volume 1301.

Advances in experimental medicine and biology ; Volume 1301

Language:

English

Subjects (All):

Cell death.

Physical Description:

1 online resource (IX, 140 p. 37 illus., 33 illus. in color.)

Edition:

1st ed. 2021.

Place of Publication:

Cham, Switzerland : Springer, [2021]

Summary:

This book focuses on the emerging role of ferroptosis in human diseases. It gives a detailed perspective on how to induce or suppress ferroptosis to treat challenging conditions such as infectious diseases, including COVID-19, tuberculosis, parasitic diseases and cancer. The book serves as a practical guide by providing a valuable collection of all currently known activators or inhibitors of ferroptosis. It will enable readers to choose molecules for experimental design for in vitro and in vivo studies of ferroptosis. Furthermore, this volume highlights the aspects of iron metabolism and its connection to ferritinophagy, a ferritin selective autophagy, with profound implications in neurodegenerative diseases such as Alzheimer, Parkinson, Huntington and ALS. Lastly, it describes necroptosis, another important form of cell death, along with its connections to human disorders and potential crosstalk with ferroptosis. While covering basic concepts, the book delves into mechanisms and modulation of ferroptosis for treating a wide variety of human diseases thus offering a valuable and informative resource for both, scientists and clinical researchers.

Contents:

Foreword

Ferroptosis: Concepts and Definitions

Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT inhibitors

Iron Homeostasis and Metabolism: Two Sides of a Coin

The Role of NCOA4-mediated Ferritinophagy in Ferroptosis

Emerging Role for Ferroptosis in Infectious Diseases

Small Molecule Regulators of Ferroptosis

Necroptosis, The other main Caspase-Independent Cell Death.

Notes:

Description based on print version record.

Includes bibliographical references and index.

ISBN:

3-030-62026-3