Nanotechnology for bioapplications / Bong-Hyun Jun, editor.

Format:

Book

Contributor:

Jun, Bong-Hyun, editor.

Series:

Advances in experimental medicine and biology ; Volume 1309.

Advances in experimental medicine and biology ; Volume 1309

Language:

English

Subjects (All):

Nanobiotechnology.

Physical Description:

1 online resource (vi, 292 pages) : illustrations.

Edition:

1st ed.

Place of Publication:

Singapore : Springer, [2021]

Summary:

This book documents the tremendous progress in the use of nanotechnology for a range of bioapplications with the aim of providing students, researchers, technicians, and other professionals with an up-to-date overview of the field.

Contents:

Intro

Contents

1: Introduction of Nanobiotechnology

1.1 Introduction

1.2 What Is Nanotechnology?

1.2.1 How Small Is Nano?

1.2.2 Nanofabrication and Analytical Tools

1.2.3 Exotic Properties of the Nanomaterials

1.3 Classification of Nanomaterials and Their Application

1.3.1 Metal NPs

1.3.2 Magnetic NPs

1.3.3 Quantum Dots (QDs)

1.3.4 Silica NPs

1.3.5 Carbon NPs

1.4 Nanotoxicology and Future Perspective

Bibliography

2: General in Colloidal Nanoparticles

2.1 Introduction

2.2 Fabrication of Nanoparticles

2.2.1 Nucleation and Growth

2.2.1.1 Nucleation

2.2.1.2 Growth Kinetics

2.2.2 Size Control

2.2.2.1 Nucleation Control

2.2.2.2 Ostwald Ripening and Sintering

2.2.2.3 Microemulsion Method (Template-Based Method)

2.3 Stabilization of Nanocrystals Against Aggregation

2.3.1 Aggregation

2.3.2 Surface Charge

2.3.3 Electrical Double Layer

2.3.4 Van der Waals Attraction

2.3.5 DLVO (Derjaguin, Landau, Verwey, Overbeek) Theory

2.3.6 Steric Stabilization

3: Silica Nanoparticles

3.1 Introduction

3.2 Synthesis of Silica Nanoparticles

3.2.1 Stöber Method (Nucleation and Growth)

3.2.2 Reverse Microemulsions

3.2.3 Modified Sol-Gel Method for Silica Coating

3.2.4 Modified Sol-Gel Method for Controlling Shape and Porosity

3.3 Surface Modification for Functionalization of Silica Nanoparticles

3.4 Various Nanoparticles Applied to Silica

3.4.1 Various Silica-Coated Nanoparticles

3.4.2 Porous Silica Nanoparticles

3.4.3 Synthesis of Various Nanoparticles Using Silica as a Template

3.5 Various Silica-Applied Nanoparticles for Bioapplications

3.5.1 Biosensing and Bioimaging for Diagnostics

3.5.2 Drug Delivery

3.5.3 Multifunctional Silica Nanoparticles

3.6 Conclusion.

Bibliography

4: Luminescent Nanomaterials (I)

4.1 Introduction

4.2 Basics of Fluorescence

4.2.1 Light and Luminescence

4.2.2 Fluorescence Process and Related Terminologies

4.2.3 Organic Dyes As Fluorophores

4.3 Luminescent Nanoparticles

4.3.1 Fluorescence Organic Dye-Incorporated Materials

4.3.1.1 Dye-Doped Silica Nanoparticles

4.3.1.2 Fluorescence-Encoded Beads

4.3.2 Quantum Dots (QD)

4.3.2.1 Fundamentals of QDs

Quantum Confinement Effect

Optical Properties

Quantum Yield and Surface Structures

4.3.2.2 Synthesis of Quantum Dots

4.3.2.3 Surface Modifications

4.3.3 Upconversion Fluorescent Nanoparticles

4.3.3.1 Fundamentals of UCNPs

4.3.3.2 Synthesis and Surface Modification of UCNPs

4.3.4 Other Luminescent Nanomaterials

4.3.4.1 Europium-Based Materials

4.3.4.2 Noble Metal Nanoclusters

4.3.4.3 Other Carbon-Based QDs

References

5: Luminescent Nanomaterials (II)

5.1 Sensing Mechanisms and Techniques

5.1.1 Förster Resonance Energy Transfer (FRET)

5.1.2 Time-Resolved Fluorescence (TRF)

5.1.3 Flow Cytometry

5.2 Bioanalytical and Biomedical Application

5.2.1 Quantum Dot

5.2.2 UCNPs-Based Analysis

5.2.3 Europium-Based Analysis

5.3 Bioimaging

5.3.1 QD-Based Bioimaging

5.3.2 UCNPs-Based Imaging

5.3.3 Europium-Activated Luminescent Nanoprobes

5.3.4 NIR-II Imaging

5.4 Therapeutics Cooperated with Luminescent Nanoparticles

5.4.1 Drug Delivery

5.4.2 Photothermal Therapy

5.4.3 Photodynamic Therapy

5.5 Conclusions and Outlook

6: Plasmonic Nanoparticles: Basics to Applications (I)

6.1 Introduction

6.2 Synthesis of Metal Nanoparticles

6.2.1 General Information

6.2.2 Citrate Reduction Method

6.2.3 Reverse Micelle Method

6.2.4 Polyol Method.

6.3 Property of Metal Nanoparticles

6.3.1 General Information

6.3.2 Localized Surface Plasmon Resonance

6.3.3 Effects of Size, Shape, Composition, and Environment

6.3.3.1 Size-Dependent Optical Property

6.3.3.2 Shape-Dependent Optical Property

6.3.3.3 Composition-Dependent Optical Property

6.3.3.4 Effect of Interactions with Mediums and Between NPs

6.4 Metal-Enhanced Process

6.4.1 Surface-Enhanced Fluorescence (SEF)

6.4.2 Surface-Enhanced Raman Scattering (SERS)

6.4.3 Plasmon Resonance Energy Transfer (PRET)

6.5 Basics for Biomedical Application of Metal Nanoparticles

7: Plasmonic Nanoparticles: Advanced Researches (II)

7.1 Advanced Synthetic Researches

7.2 Recent Advanced Application in Biomedical Research

7.2.1 In Vitro Biosensors

7.2.2 Intracellular Detection and Ex Vivo/In Vivo Imaging

7.2.3 Therapeutic Applications

7.3 Conclusions and Outlook

8: Magnetic Nanoparticles

8.1 Introduction

8.2 Synthesis of Magnetic Nanoparticles

8.2.1 General Information

8.2.2 Coprecipitation

8.2.3 Thermal Decomposition

8.2.3.1 New Type of Thermal Decomposition

8.2.4 Microemulsion

8.3 Physical Properties of Magnetic Nanoparticles

8.3.1 Units of Magnetic Property

8.3.2 Hysteresis Effect, Coercivity, and Remanence

8.3.3 Domain Theory

8.3.4 Magnetic Properties of Nanoparticles

8.3.5 Curie Temperature

8.4 Magnetism

8.4.1 Classification of Magnetism

8.4.2 Ferromagnetism

8.4.3 Ferrimagnetism

8.4.4 Superparamagnetism

8.5 Current Trends of Magnetic Nanoparticles

8.5.1 Separation/Purification of Biomolecules

8.5.2 Hyperthermia

8.5.3 Drug Delivery

8.5.4 Magnetic Resonance Imaging (MRI)

8.5.5 Multifunctional Nanocomposites Possessing Magnetic Property.

8.5.5.1 Multimodal Imaging

8.5.5.2 Theragnosis/Theragnostics

9: Lithography Technology for Micro- and Nanofabrication

9.1 Introduction

9.2 Conventional Lithography

9.2.1 Photolithography

9.2.2 High-Energy Beam Lithography

9.2.2.1 Electron Beam Lithography

9.2.2.2 Focused Ion Beam Lithography

9.3 Unconventional Lithography

9.3.1 Nanoimprint Lithography (NIL)

9.3.1.1 Thermal NIL

9.3.1.2 UV-NIL

9.3.2 Deformation of Material-Based Lithography

9.3.2.1 Wrinkling

9.3.2.2 Cracking

9.3.2.3 Collapsing

9.3.3 Colloidal Lithography

9.3.3.1 Self-Assembly of Colloidal Particles

9.3.3.2 Colloidal Particle-Based Patterning

9.4 Overlook and Conclusions

10: Bioapplications of Nanomaterials

10.1 Overview

10.2 Pharmaceutical Applications

10.2.1 Drug Delivery and Targeting Strategies

10.3 Biosensing and Biochips

10.3.1 SERS-Based Intracellular Biosensing

10.3.1.1 Gaseous Sensing

10.3.1.2 pH Sensing

10.3.1.3 Reactive Oxygen Species (ROS)

10.3.1.4 Redox Potential Sensing

10.3.2 Detection of Biomolecules by SERS

10.3.2.1 Proteins

10.3.2.2 DNA

10.3.2.3 Metabolite

10.3.2.4 Pathogens

10.4 Gene Delivery

10.5 Bioimaging

10.5.1 SERS-Based Cellular Imaging

10.5.2 Imaging of Cell Surface Species

10.5.3 Endocytic Pathway

10.5.4 Cell Cycle and Apoptotic Process

10.5.5 Cell Secretion

10.6 Cancer Diagnostics and Therapeutics

11: Carbon Nanomaterials for Biomedical Application

11.1 Introduction

11.2 Properties of Carbon-Based Nanomaterials

11.2.1 Graphite and Fullerene

11.2.2 Carbon Nanotube

11.2.3 Graphene and Derivatives

11.3 Surface Functionalization of Carbon Nanomaterials

11.3.1 Noncovalent Surface Chemistry.

11.3.2 Covalent Surface Chemistry

11.4 Carbon Nanomaterials for Biological Applications

11.4.1 In Vitro Sensing Elements and Diagnostics

11.4.2 Graphene Nanopore and Graphene Liquid Cell

11.4.3 Functional 3D Carbon Nanomaterials

11.4.4 Photothermal Therapy

11.4.5 Tissue Engineering Using Carbon Materials

11.5 Conclusions and Outlook

12: Optical and Electron Microscopy for Analysis of Nanomaterials

12.1 Introduction

12.2 Optical Microscopy

12.3 Electron Microscopy (EM)

12.3.1 Transmission Electron Microscopy (TEM)

12.3.2 Scanning Electron Microscopy (SEM)

12.4 Scanning Probe Microscopy (SPM)

12.4.1 Scanning Tunneling Microscopy (STM)

12.4.2 Atomic Force Microscopy (AFM)

12.4.3 Near-Field Scanning Optical Microscopy (NSOM)

12.5 Outlook and Summary

13: Conclusion and Perspective

13.1 Conclusion

13.2 Perspective.

Notes:

Includes bibliographical references.

Description based on print version record.

Description based on publisher supplied metadata and other sources.

ISBN:

981-336-158-1

OCLC:

1244621407