New Rapid-acting Antidepressants / edited by Kenji Hashimoto, Mario Manto.

Format:

Book

Contributor:

Hashimoto, Kenji, editor.

Manto, Mario, editor.

Series:

Contemporary Clinical Neuroscience, 2627-5341

Language:

English

Subjects (All):

Neurosciences.

Neuroscience.

Local Subjects:

Neuroscience.

Physical Description:

1 online resource (152 pages)

Edition:

1st ed. 2021.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2021.

Summary:

This book discusses new candidates for rapid-acting antidepressants, such as (R)-ketamine, (2R,6R)-hydroxynorketamine, scopolamine, mGluR2/3 antagonists and AMPA receptor agonists. There are serious limitations to currently available antidepressants, such as delayed onset and low rates of efficacy. The discovery that a single dose of ketamine, an NMDAR antagonist, can produce rapid antidepressant effects that are sustained has led to new research in this area. In this volume, a variety of novel pharmaceutical treatments are examined. This volume would be useful to both researchers and clinicians who work in the field of pharmacology, specifically CNS drug treatments. Discusses new candidate for rapid-acting antidepressants Provides information for those who work in the field of CNS drugs Ideal for pharmacologists, psychiatrists, and those who want to learnabout CNS drugs at the graduate level.

Contents:

(R)-ketamine: A new rapid-acting antidepressant

(2R,6R)-hydroxynorketamine, a metabolite of ketamine: the antidepressant actions and the mechanisms

Predictable biomarkers for rapid-acting antidepressant response to ketamine

Nitrous Oxide: an old compound with emerging psychotropic properties

Novel AMPA receptor potentiators TAK-137 and TAK-653 as potential rapid-acting antidepressants

AMPA receptor potentiators as potential rapid-acting antidepressants

mGlu2/3 receptor antagonists as rapid-acting antidepressants

Antidepressant effects of the muscarinic receptor antagonist scopolamine: Clinical and preclinical review.

Notes:

Includes index.

ISBN:

3-030-79790-2

OCLC:

1280461997