The collagen superfamily and collagenopathies / Florence Ruggiero, editor.

Format:

Book

Contributor:

Ruggiero, Florence, editor.

Series:

Biology of extracellular matrix ; Volume 8.

Biology of extracellular matrix ; Volume 8

Language:

English

Subjects (All):

Cytology.

Physical Description:

1 online resource (IX, 338 p. 28 illus., 24 illus. in color.)

Edition:

1st ed. 2021.

Place of Publication:

Cham, Switzerland : Springer, [2021]

Summary:

This book aims at providing insights into the collagen superfamily and the remarkable diversity of collagen function within the extracellular matrix. Additionally, the mechanisms underlying collagen-related diseases such as dystrophic epidermolysis bullosa, osteogenesis imperfecta, as well as collagen-related myopathies and neurological disorders are discussed. Collagens are the most abundant extracellular matrix proteins in organisms. Their primary function is to provide structural support and strength to cells and to maintain biomechanical integrity of tissues. However, collagens can no longer be considered just as structural proteins. They can act as extracellular modulators of signaling events and serve critical regulatory roles in various cell functions during embryonic development and adult homeostasis. Furthermore, collagens are associated with a broad spectrum of heritability-related diseases known as “collagenopathies” that affect a multitude of organs and tissues including sensorial organs. The book is a useful introduction to the field for junior scientists, interested in extracellular matrix research. It is also an interesting read for advanced scientists and clinicians working on collagens and collagenopathies, giving them a broader view of the field beyond their area of specialization.

Contents:

Chapter 1: Introduction to the collagen superfamily

Chapter 2: Collagen IV-related disease

Chapter 3: Articular collagens related diseases

Chapter 4: Collagens as new players of nervous system disease

Chapter 5: Collagens and EDS

Chapter 6: Collagens and dystrophic epidermolysis bullosa

Chapter 7: Collagen-related myopathies: pathogenic mechanisms and prospective therapies

Chapter 8: Procollagen trafficking and its implications in Osteogenesis Imperfecta.

Notes:

Description based on print version record.

ISBN:

3-030-67592-0

OCLC:

1251764832