Cardiomyocytes in Health and Disease / by Chandrasekharan C. Kartha.

Format:

Book

Author/Creator:

Kartha, C. Chandrasekharan, author.

Series:

Biomedical and Life Sciences Series

Language:

English

Subjects (All):

Cardiovascular system.

Physiology.

Cardiology.

Regenerative medicine.

Medicine--Research.

Medicine.

Biology--Research.

Biology.

Cardiovascular Physiology.

Regenerative Medicine and Tissue Engineering.

Biomedical Research.

Local Subjects:

Cardiovascular Physiology.

Cardiology.

Regenerative Medicine and Tissue Engineering.

Biomedical Research.

Physical Description:

1 online resource (356 pages)

Edition:

1st ed. 2021.

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2021.

Summary:

This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon. .

Contents:

Section I: Normal Cardiomyocyte and its Growth

1. Structure and Function of Cardiomyocyte

2. Development of Cardiomyocyte

3. Cell Cycle Regulation in Cardiomyocytes

4. Cardiac Fibroblast and Cardiomyocyte Growth

5. Role of Endocardium and Epicardium in Generation of Cardiomyocytes

Cardiomyocytes in the Mammalian Adult Heart

7. Energy Metabolism in Cardiomyocytes

Section II: Cardiomyocyte Responses 8. Response of Cardiomyocytes to Mechanical Stress

Cardiomyocyte Responses to Hormones 10. Sequelae of Genetic Defects in Cardiomyocytes

11. Response and Effects of Cardiomyocyte Progenitors in the Infarcted Heart

Section III: Cardiomyocyte Aging and Death

12. Cardiomyocyte Senescence

13. Mechanisms of Cardiomyocyte Death

14. Cardiomyocyte Response to Ischemic Injury

15. Cardiomyocytes in Heart Failure

Section IV: Cardiomyocyte Regeneration

16. Endogenous Mechanisms for Cardiomyocyte Regeneration

17. Mechanisms to Induce Cardiomyocyte Proliferation

18. Cell Sources of Cardiomyocytes for Heart Repair

19. Reprograming Fibroblasts for Cardiomyocytes and Progenitors

Section V: Translational Aspects of Cardiomyocyte Biology

20. Clinical Translation of Discoveries in Cardiomyocyte Biology.

Notes:

Includes bibliographical references and index.

ISBN:

3-030-85536-8

OCLC:

1268325517