The Patient Equation : The Data-Driven Future of Precision Medicine and the Business of Health Care.

Format:

Book

Author/Creator:

de Vries, Glen.

Contributor:

Blachman, Jeremy.

Language:

English

Subjects (All):

Precision Medicine.

Data Collection.

Biomedical Technology.

Monitoring, Ambulatory.

Data Science.

Medical Subjects:

Precision Medicine.

Data Collection.

Biomedical Technology.

Monitoring, Ambulatory.

Data Science.

Physical Description:

1 online resource (291 pages)

Other Title:

Patient Equation

Place of Publication:

Newark : John Wiley & Sons, Incorporated, 2020.

Summary:

How the data revolution is transforming biotech and healthcare--and why you can't afford to let it pass you byWe are living through a time when the digitization of health and medicine is becoming a reality, with new abilities to improve outcomes for patients as well as the efficiency and success of the organizations that serve them. In The Patient Equation, Glen de Vries presents the history and current state of life sciences and healthcare as well as crucial insights and strategies to help scientists, physicians, executives, and patients survive and thrive in the current disruptive, tech-driven landscape. The biggest challenge facing biotech, pharma, and medical device companies today is how to integrate new knowledge, new data, and new technologies to get the right treatments to the right patients at precisely the right times. This book shows you how to meet that challenge and embrace the data revolution.Drawing on the fascinating stories of businesses and individuals that are already making inroads--from a fertility-tracking bracelet changing the game for couples looking to get pregnant, to an entrepreneur reinventing the treatment of diabetes, to Medidata's own work bringing clinical trials into the 21st century--de Vries shares the breakthroughs, approaches, and practical business techniques that allow companies to stay ahead of the curve and to deliver solutions faster, cheaper, and more successfully--while still upholding the principles of traditional therapeutic medicine.How one rare disease is leading the way for new approaches to understanding precision medicineWhat it means to build robust, effective disease management platformsWhy value-based reimbursement is changing the business of life sciencesHow the right alignment of incentives will improve outcomes at every stage of the patient journeyWhether you're a scientist, physician, or executive, you can't afford to let the data revolution pass you by: understand the landscape with this must-read roadmap for success--and see how you can change the future of healthcare for the better.

Contents:

Cover

Title Page

Copyright

Contents

Introduction

PART 1 From Hippocrates to Epocrates

Chapter 1 Before We Cured Scurvy

Nanometers to Megameters

Scurvy

The False Promise of Genotype

Your Very Own High‐frequency Medical Device

Notes

Chapter 2 Inside the Equations

Like Lions of the Serengeti

The Layer Cake

Patients Like You, Patients Like Me

Changing the Frequency

Reverse‐engineering the Critical Layers

The Cognitive Dimension

Better Measurements at Virtually No Cost

From Hypothesis Confirmation to Hypothesis Generation

Chapter 3 Fitbits, Smart Toilets, and a Bluetooth‐enabled Self‐driving ECG

Are Apps the New Snake Oil?

Wearables for Panicked Dogs

It's the Equations, Not the Devices

Let's Start with the Thermostat

PART 2 Applying Data to Disease

Chapter 4 Ava-Tracking Fertility, on the Road Toward Understanding All of Women's Health

Enter Ava

The Changing Role of the Patient

The Motivation to Comply

A Man Who Just Can't Ovulate

Finding a Niche in a Crowded Field

Chapter 5 One Breath, One Drop-Asthma and Diabetes, Chronic Conditions Being Conquered with Technology

Out of the Danger Zone

Lowering Barriers to Zero

A Perfectly Artificial Pancreas

Hacking One's Own Device

One Drop at a Time

Chapter 6 Flumoji and Sepsis Watch-Two Approaches to Predicting and Preventing Acute, Life‐threatening Conditions Through Smarter Data

Catching Sepsis Earlier

Partnering with Doctors, Not Replacing Them

Looking Beyond Sepsis

Using Crowdsourcing to Track the Flu

Stopping the Spread of Illness with Data Is Hard

Chapter 7 Cancer and Phage Therapy-Crafting Custom Treatments Just for You

Changing the Way We Look at Cancer

p53‐ologists of the Future.

Or Perhaps Car‐t‐ographers of the Present

Personalized Immunotherapy Beyond Cancer

Chapter 8 Castleman Disease-Not One RareDisease with NoTreatments, ButThree Rare Diseases. . . with Hope,Thanks to Data

Finding Clusters in a Random World

Dr. David Fajgenbaum's Quest for a Cure

Rare Diseases, Common Problems

PART 3 Building Your Own Patient Equations

Chapter 9 The Steam Table

Progressing Toward Alzheimer's Disease...or Maybe Not

When the Measurement and the Therapy Are One and the Same

Steam Tables for Cancer

The Data Problem

From Wellness to Illness-and Back Again

Chapter 10 Good Data

The Failure of Watson

The Mars Climate Orbiter

The Progression to Value

Chapter 11 Changing Clinical Trials

Expanding Access to Trials

Pharma's Lack of Connection to Clinical Care

Truly Patient‐centric Trials

Accepting New Kinds of Data

Unshackling the Clinical Trial

Enter Thomas Bayes

Breaking the Barrier

Synthetic Control Arms

Our Synthetic Control Model

Making Every Trial an Adaptive Trial

A Stroke of Insight

Chapter 12 Disease Management Platforms

The Promise of Mobile Apps

Digital from the Beginning

But It's Not That Easy

Where That Leaves Us

PART 4 Scaling Progress to the World

Chapter 13 The Importance of Collaboration

A Tiny Island or a Larger Ecosystem

How Data Collaboration Can Change the Game

Chapter 14 Value‐based Reimbursement

Beyond Survival

The (Mathematical) Fountain of Youth

Money‐back Guarantee

Making Value‐based Care the Future

Chapter 15 Aligning Incentives

Human Doctors, Digital Doctors

Respecting the Unquantifiable

Empowered Patients

Chapter 16 And Then, a Pandemic

Phase Diagrams Revisited.

Steam Tables, Sensors, and Early Warning Systems

Putting a Spotlight on the Fragility of Our System

A Speedier Road to Modernized Trial Design

The Next Hundred Years

Conclusion

Acknowledgments

About the Authors

Index

EULA.

Notes:

Description based on publisher supplied metadata and other sources.

ISBN:

9781119755753

1119755751

9781119755760

111975576X

9781119622178

1119622174

9781119622277

1119622271

OCLC:

1181842971