Drug-biomembrane interaction studies : the application of calorimetric techniques / edited by Rosario Pignatello.

Format:

Book

Contributor:

Pignatello, Rosario, editor.

Series:

Woodhead Publishing series in biomedicine ; no. 45.

Woodhead Publishing series in biomedicine, 2050-0289 ; number 45

Language:

English

Subjects (All):

Drug interactions.

Membranes (Biology).

Calorimetry.

Physical Description:

1 online resource (xlv, 389 pages) : illustrations.

Place of Publication:

Cambridge, UK : Woodhead Publishing, 2013.

Language Note:

English

Summary:

The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC is an accurate and rapid thermo-analytical technique,

Contents:

Cover; Drug-biomembrane interaction studies: The application ofcalorimetric techniques; Copyright; Dedication; Contents; Figures; Tables; List of abbreviations; Preface; About the editor and contributors; 1 Biological membranes and their role in physiopathological conditions; 1.1 Importance of drug- biomembrane interactions in biomedical and pharmaceutical research; 1.2 The structure of cell membranes; 1.3 Properties of plasma membranes; 1.4 Movement of molecules across the plasma membrane; 1.5 Functions of cell membranes; 1.6 Conclusion; 1.7 References; 1.8 Further reading

2 Biomembrane models2.1 Introduction; 2.2 The fluid mosaic model of a biological membrane; 2.3 Lipid phases and lipid phase transitions; 2.4 Models of biological membranes and their applications; 2.5 Conclusion; 2.6 References; 3 Analytical methods for studying drug-biomembrane interactions; 3.1 Introduction; 3.2 Spectroscopic techniques; 3.3 Chromatographic methods; 3.4 Zeta potential measurement; 3.5 Microscopy techniques; 3.6 The Langmuir-Blodgett (LB) film balance technique; 3.7 Other techniques and mixed techniques; 3.8 Conclusions; 3.9 References

4 Differential scanning calorimetry (DSC): theoretical fundamentals4.1 Introduction; 4.2 Brief survey of the main thermodynamic techniques; 4.3 Application to lipid systems; 4.4 Membrane partitioning and binding of additives; 4.5 The effects of additives on membrane properties; 4.6 Kinetic phenomena; 4.7 References; 5 DSC: history, instruments and devices; 5.1 Introduction; 5.2 History; 5.3 Instruments; 5.4 Special devices; 5.5 References; 5.6 Further reading; 6 DSC in drug-biomembrane interaction studies; 6.1 Introduction; 6.2 Aims and advantages of DSC; 6.3 Drug-biomembrane interactions

6.4 Surfactants6.5 Genetic materials; 6.6 Polymers; 6.7 Drug delivery systems (DDSs); 6.8 Toxicity of biomolecules; 6.9 Conclusion; 6.10 References; 7 DSC applications: macromolecules; 7.1 Introduction; 7.2 Proteins; 7.3 Nucleic acids; 7.4 Polysaccharides; 7.5 Biopolymers; 7.6 Conclusion; 7.7 References; 8 DSC applications: nucleic acids and membrane interactions; 8.1 Introduction; 8.2 DNA-membrane interaction studies with DSC; 8.3 RNA-membrane interaction studies with DSC; 8.4 Conclusions; 8.5 References; 9 Nonsteroidal antiinflammatory drugs; 9.1 Introduction to antiinfl ammatory drugs

9.2 The interaction of NSAIDs with biomembrane models9.3 NSAID-loaded DDSs; 9.4 Conclusion; 9.5 References; 10 Antimicrobial agents; 10.1 Introduction; 10.2 What are the appropriate biomembrane models for antimicrobial agents?; 10.3 Antivirals, virus envelopes, and biomembrane models; 10.4 Antifungals and biomembrane models; 10.5 Conclusion; 10.6 References; 11 Drug delivery systems: drug nanocarriers; 11.1 Introduction; 11.2 Drug delivery systems; 11.3 Experimental protocols; 11.4 Applications; 11.5 References; Appendix 1: General experimental setup of liposomal systems for DSC

A1.1 Introduction

Notes:

Includes bibliographical references and index.

Description based on print version record.

"ISSN: 2050-0289."

ISBN:

9781908818348

1908818344

OCLC:

864746139