WHO guideline for clinical management of exposure to lead / Joanna Tempowski ; World Health Organization, issuing body.

Format:

Book

Author/Creator:

Tempowski, Joanna, author.

Contributor:

World Health Organization, issuing body.

Language:

English

Subjects (All):

Lead--Toxicology.

Lead.

Clinical medicine.

Physical Description:

1 online resource (91 pages) : illustrations

Edition:

1st ed.

Place of Publication:

Geneva : World Health Organization, [2021]

Summary:

The purpose of the WHO guideline for clinical management of exposure to lead is to assist physicians in making decisions about the diagnosis and treatment of lead exposure for individual patients and in mass poisoning incidents. The guidelines present evidence-informed recommendations on i) the interpretation of blood lead concentrations; ii) use of gastrointestinal decontamination; iii) use of a chelating agent; and iv) use of nutritional supplements.

Contents:

Intro

Contents

Acknowledgements

Abbreviations and acronyms

Executive Summary

The Guideline

01 / Purpose and scope

02 / Methods for guideline development

2.1 Contributors to the guideline

2.2 Identification of priority questions and critical outcomes

2.3 Identification and retrieval of evidence

2.4 Quality assessment and grading of evidence

2.6 Development of recommendations

2.7 Good practice statements

2.8 Consultation with stakeholders

2.9 Document preparation and peer review

03 / Results of the review

3.1 Guiding principles

04 / Background

4.1 Principal sources of exposure to lead

4.2 Routes of exposure to lead

4.3 Toxicokinetics

4.4 Toxicity of lead

4.5 Toxic effects in relation to blood lead concentrations

05 / Diagnosis of lead poisoning

06 / Recommendation on the blood lead concentration that should initiate clinical interventions

6.1 Introduction

6.2 Recommendations for all age groups

6.3 Values, equity, feasibility and acceptability of a 5 µg/dL threshold value

6.4 Considerations for implementation

07 / Recommendations for specific treatment interventions

7.1 Gastrointestinal decontamination after ingestion of a lead foreign body or other lead-containing material

7.2 Nutritional interventions in children and in pregnant and lactating women exposed to lead

7.3 Chelation therapy in individuals exposed to lead

08 / Integration and implementation of the recommendations in the management of lead poisoning

8.1 Taking a history to Identify the source(s) of exposure

8.2 Evaluation of the severity of exposure

8.3 Reduction and termination of exposure, including improving nutrition

8.4 Chelation therapy

8.5 Supportive measures

8.6 Follow-up

09 / Research gaps

9.1 Gastrointestinal decontamination.

9.2 Nutritional interventions

9.3 Chelation therapy

10 / Considerations for implementation of the guideline

References

Annex 1 Members of the WHO Steering Group

Annex 2 Guideline Development Group

Annex 3

Research questions and critical and important outcomes

Annex 4 External reviewers

Annex 5Flowcharts summarizing aspects of patient management.

Notes:

Includes bibliographical references.

Description based on: online resource; title from PDF title page (NCBI, viewed November 5, 2022).