Semiconducting silicon nanowires for biomedical applications / editor, Jeffery L. Coffer.

Format:

Book

Contributor:

Coffer, Jeffery, editor.

Series:

Woodhead Publishing series in biomaterials

Language:

English

Subjects (All):

Biomedical materials.

Nanosilicon.

Nanowires.

Semiconductors.

Nanotechnology--methods.

Medical Subjects:

Nanowires.

Semiconductors.

Nanotechnology--methods.

Physical Description:

1 online resource (442 pages)

Edition:

Second edition.

Place of Publication:

Duxford, England ; Cambridge, Massachusetts : Woodhead Publishing, [2022]

Summary:

In its second, extensively revised second edition, Semiconducting Silicon Nanowires for Biomedical Applications reviews the fabrication, properties, and biomedical applications of this key material.The book begins by reviewing the basics of growth, characterization, biocompatibility, and surface modification of semiconducting silicon nanowires.

Contents:

Front cover

Half title

Full title

Copyright

Contents

Contributors

About the Editor

Foreword

Chapter One - An overview of semiconducting silicon nanowires for biomedical applications

1.1 Introduction

1.2 Historical origins

1.3 The structure of this book

1.4 Final comments

References

Chapter Two - Growth and characterization of silicon nanowires for biomedical applications

2.1 Introduction

2.2 Synthesis methods

2.2.1 Chemical etching of silicon wafers

2.2.2 Chemical vapor deposition for silicon nanowire growth

2.2.2.1 Growth of intrinsic (undoped) silicon nanowires

2.2.2.2 Growth of p-type or n-type silicon nanowires

2.2.2.3 Growth of millimeter-long silicon nanowires

2.2.2.4 Growth of axial silicon nanowire heterostructures

2.2.2.5 Growth of radial Si NW heterostructures

2.2.2.6 Growth of kinked or zigzag Si NWs

2.2.2.7 Growth of branched silicon nanowires

2.2.3 Solution-liquid-solid growth of silicon nanowires

2.3 Characterization methods

2.3.1 Electron microscopy techniques

2.3.2 Raman spectroscopy

2.3.3 Electrical transport measurement

2.4 Example: Synthesis of semiconductor Si NWs by the CVD method

2.5 Conclusion

Future trends

Chapter Three - Surface modification of silicon nanowires for biosensing

3 .1 Introduction

3 .2 Fabrication of silicon nanowires

3 .3 Chemical activation/passivation of silicon nanowires

3.3.1 Modification of native oxide SiO x /SiNWs

3.3.2 Modification of hydrogen-terminated silicon nanowires

3 .4 Modification of native oxide layer

3.4.1 Silanization reaction

3.4.1.1 Control of wetting properties by introduction of alkyl or ­perfluoroalkyl chains on silicon nanowires

3.4.1.2 Amine-terminated silicon nanowires ( Fig. 3.2 ).

3.4.1.3 Thiol-terminated silicon nanowires ( Figs. 3.2 - 3.3 )

3.4.1.4 Epoxy-terminated silicon nanowires

3.4.1.5 Aldehyde-terminated silicon nanowires

3.4.1.6 Vinyl-terminated silicon nanowires

3.4.1.7 Modification with carboxylic acid/organosilane reagents

3.4.2 Post-functionalization

3.4.3 Heterobifunctional cross-linkers

3.4.4 Reaction with organophosphates ( Figs. 3.2 - 3.7 )

3. 5 Modification of hydrogen-terminated silicon nanowires

3.5.1 Hydrosilylation reaction

3.5.2 Deprotection

3.5.3 Post-modification/cross-linking

3.5.4 Halogenation/alkylation followed by Grignard reaction

3.5.5 Electrografting on hydrogen-terminated silicon nanowires

3.5.6 Arylation via aryldiazonium salt

3 .6 Site-specific immobilization strategy of biomolecules on silicon nanowires

3.6.1 Native chemical ligation

3.6.2 "Click" chemistry

3 .7 Control of non-specific interactions

3. 8 Photochemistry

3 .9 Inorganic functionalization

3 .10 Conclusion

Chapter Four - Biocompatibility of semiconducting silicon nanowires

4 .1 Introduction

4 .2 In vitro biocompatibility of silicon nanowires

4.2.1 Cytotoxicity

4.2.2 Osseointegration

4.2.3 Hemocompatibility

4. 3 In vivo biocompatibility of silicon nanowires

4. 4 Methodology issues

4.4.1 Improper material characterization

4.4.2 Modus operandi issues

4. 5 Future trends

4.5.1 Lack of data about the biocorona

4.5.2 Genotoxicity profiling

4.5.3 Potential production of reactive oxygen species

4. 6 Conclusion

Chapter Five - Functional silicon nanowires for cellular binding and internalization

5. 1 Developing a nano biomodel system for rational design in nanomedicine.

5 .2 Non-linear optical characterization and surface functionalization of silicon nanowires

5.2.1 Nonilinear optical imaging of silicon nanowires

5.2.2 Functionalization of silicon nanowires

5 .3 Applications: In vivo imaging and in vitro cellular interaction of functional Si NWs

5.3.1 Intravital imaging of silicon nanowires circulating in blood vessels

5.3.2 In vitro cellular response to silicon nanowires

5 .4 Understanding internalization pathways for silicon nanowires

5 .5 Conclusions and future trends

Chapter Six - Functional semiconducting silicon nanowires and their composites as tissue scaffolds

6.1 Introduction

6.2 NW surface etching processes to induce biomineralization

6.3 NW surface functionalization strategies to induce biomineralization

6.3.1 Electrochemically assisted surface functionalization

6.3.2 Covalent surface functionalization of Si NWs for osteocompatibility

6.4 Construction of Si NW - polymer scaffolds: mimicking trabecular bone

6.4.1 Si NW transfer onto highly porous polymer surfaces

6.4.2 Uniform NW transfer onto porous polymer surfaces with horizontally-oriented NWs

6.4.3 Vertical Si NW arrays on patterned polymer substrates

6.5 The role of Si NW orientation on cellular attachment, proliferation, and differentiation in the nanocomposite

6.5.1 Cell attachment assays with MSCs

6.6 Viability assays of MSCs on Si NW/PCL composites

6.7 Differentiation of MSC on Si NW/PCL composites

6.8 Recent advances in neural-based tissue engineering

6.9 Conclusions and prospects for the future

Acknowledgement

Chapter Seven - Mediated differentiation of stem cells by engineered silicon nanowires

7.1 Introduction

7.2 Methods for silicon nanowire fabrication/ in vitro experiments.

7.2.1 Electroless metal deposition method

7.2.2 Biological cell culture process

7.2.2.1 Isolation of human bone marrow-derived mesenchymal stem cells

7.2.2.2 Cellular viability

7.2.2.3 Gene expression and immunofluorescence staining

7.2.2.4 Cell fixation process

7.2.3 Material characterization

7.3 Regulated differentiation for human mesenchymal stem cells

7.4 Silicon nanowires fabricated by an electroless metal deposition method and their controllable spring constants

7.5 Mediated differentiation of stem cells by engineered silicon nanowires

7.6 Conclusions and future trends

Acknowledgements

Chapter Eight - Nanoneedle devices for biomedicine

8.1 Introduction

8.2 Drug delivery

8.2.1 NN-mediated delivery strategies

8.3 NN interface with cell membrane

8.4 Bioelectronics

8.5 Sensing, spectroscopy, and trapping

8.6 Conclusion

Chapter Nine - Therapeutic platforms based on silicon nanotubes

9.1 Introduction

9.2 Computational studies of single-walled silicon nanotubes

9.3 Fabrication and characterization of silicon nanotubes

9.4 Chemical modification strategies of Si NT surfaces with implications in therapeutics

9.5 Biodegradation properties of silicon nanotubes

9.6 Biocompatibility of silicon nanotubes

9.7 Nanotube interior filling with superparamagnetic nanoparticles for potential magnetic field-assisted drug delivery

9.8 Formation of a nanohybrid composed of Si NTs and metal nanoparticles with relevant anticancer properties

9.9 Conclusions

Chapter Ten - Cellular nanotechnologies: Orchestrating cellular processes by engineering silicon nanowires architectures

10.1 Introduction

10.2 Engineering of tunable vertically aligned nanostructure arrays.

10.3 Surface functionalization of Si NW arrays for intracellular delivery applications

10.4 The influence of Si NW array geometries on fundamental cell behavior

10.5 Vertically aligned nanostructure mediated intracellular signaling

10.5.1 Plasma membrane curvature-mediated intracellular signaling

10.5.2 Nuclear membrane curvature-mediated intracellular signaling

10.5.3 The effect of nanostructure on Rho-family GTPase signaling

10.5.4 The effect of nanostructure tip diameter on gene expression

10.6 Vertically aligned nanostructure mediated intracellular delivery

10.6.1 Silicon nanowire-mediated intracellular delivery in vitro

10.6.2 Silicon nanowire-mediated intracellular delivery in vivo

10.6.3 Underlying mechanism of vertically aligned nanostructure mediated intracellular delivery

10.7 Vertically aligned nanostructure mediated electroporation

10.7.1 Intracellular delivery

10.7.2 Intracellular recording

10.8 Conclusion

Chapter Eleven - Nanowire array fabrication for high throughput screening in the biosciences

11.1 Introduction

11.2 Fabrication methods

11.2.1 Fabrication of silicon nanowire field-effect transistors for HTS in biosciences

11.2.2 Fabrication of silicon nanowire field effect transistors via "top-down" methods

11.2.2.1 Fabrication of silicon nanowire field effect transistors via "bottom-up" methods

11.2.2.2 Fabrication of Si NW FET arrays via superlattice nanowire pattern transfer "SNAP" method

11.2.3 Surface modification of Si NW FETs for HTS in the biosciences

11.2.4 Integration of Si NW FETs with microfluidic devices for HTS in real time measurements

11.3 Examples/applications

11.3.1 DNA hybridization

11.3.2 Detection of multiple viruses and small molecules-proteins interactions.

11.3.3 Detection of multiple cancer biomarkers.

Notes:

Includes bibliographical references and index.

Description based on print version record.

Description based on publisher supplied metadata and other sources.

ISBN:

9780323851312

0323851312

OCLC:

1281970006