Chlamydia biology : from genome to disease / edited by Ming Tan, Johannes H. Hegemann, Christine Sutterlin.

Format:

Book

Contributor:

Tan, Ming, editor.

Hegemann, Johannes H., editor.

Sütterlin, Christine, editor.

Language:

English

Subjects (All):

Chlamydia infections.

Chlamydia infections--Diagnosis.

Physical Description:

1 online resource (493 pages)

Edition:

1st ed.

Place of Publication:

Norfolk, England : Caister Academic Press, [2020]

Summary:

This book provides an up-to-date review of the clinical infections caused by the two main human pathogens C. trachomatis and C. pneumoniae, as well as chapters on veterinary Chlamydia species and Chlamydia-related bacteria. Multiple chapters cover cutting-edge developments in Chlamydia research, from the basic biology of the intracellular chlamydial infection to the host immune response and work towards a Chlamydia vaccine. Also highlighted are recent advances in chlamydial genetics and genomics, which have transformed the field. For the first time in a Chlamydia book, there are chapters on Chlamydia cell division and differentiation and Chlamydia infections and the microbiota, which are two hot areas of research. Each of the nineteen chapters is written by experts, who have made major contributions through their work and come from different research groups to ensure a broad and fresh perspective. This book will be of interest to Chlamydia researchers, microbiologists, cell biologists, infectious disease clinicians, public health professionals and government policy makers. It will be especially useful for newcomers to the Chlamydia field, who will find a current and comprehensive summary of Chlamydia research in one volume.

Contents:

Intro

Contents

Foreword

A note on usage

Dedication

1. Chlamydia trachomatis Infections

Introduction

Epidemiology

Clinical manifestations and complications

Diagnosis and screening for C. trachomatis infections

Clinical management

Trachoma

Clinical manifestations of trachoma

Management of trachoma

Conclusion

2. Chlamydia pneumoniae Infections

History

Clinical epidemiology

Animal models of C. pneumoniae respiratory tract infection

Chronic respiratory conditions linked to C. pneumoniae infection

Cardiovascular infections

Other diseases associated with C. pneumoniae

Future directions

3. Chlamydia Adhesion and Invasion

Experimental approaches to study Chlamydia binding and entry

The role of the host cytoskeleton and endocytic machinery in Chlamydia invasion

Bacterial adhesion proteins and their corresponding host cell receptors

Secreted Chlamydia effectors relevant to invasion

Concluding remarks and future research directions

4. The Chlamydial Inclusion

Inclusion architecture and composition

Inclusion membrane proteins (Incs)

The early inclusion - towards the cell centre

The growing inclusion

The late inclusion

New methods to characterize the inclusion-host interface

Chlamydia development without an inclusion?

Summary and outlook

5. Interactions of the Chlamydial Inclusion with the Host Cell

Interaction of the inclusion with the host cell cytoskeleton and the centrosome

Membrane-bound organelles that are actively recruited to the inclusion

Organelles that have been detected inside the inclusion

Conclusions

6. Chlamydia and Cell-autonomous Defence: Apoptosis and Autophagy

What is apoptosis?

Why may apoptosis be relevant to chlamydial infection?.

Apoptosis inhibition by chlamydial infection

Molecular mechanism of apoptosis inhibition by Chlamydia

What is autophagy?

How does autophagy function in cell-autonomous defence?

Why may autophagy be relevant for Chlamydia?

Interaction of Chlamydia with the autophagic pathway

Concluding remarks

7. Protein Secretion in Chlamydia

Secretion mechanisms in Chlamydia

Mechanistic insights into T3S

Substrates of T3S: what, when and how?

8. The Chlamydial Protease CPAF

The protease

CPAF substrates

Localization

Regulation of CPAF-dependent proteolysis

Function

CPAF: looking ahead

9. Chlamydia Cell Division and Differentiation

Cell division complex/components

Chlamydia peptidoglycan and its role in cell division

What we can learn from Chlamydia-like organisms

Mechanism of Chlamydia replication

Models for Chlamydia differentiation

Conclusions and future perspectives

10. Chlamydia Gene Regulation

The transcriptional machinery: RNA polymerase

Transcriptional regulation by transcription factors

Transcriptional regulation by changes in DNA structure

Regulation of transcription during the Chlamydia developmental cycle

Sigma factors and their potential regulators

Chlamydial transcription factors not linked with the developmental cycle

Regulation of chlamydial gene expression by small RNAs

New genetic tools and approaches for investigating mechanisms of gene regulation

Final words

11. Chlamydia Genetics

Bacterial competence in Chlamydia

Vector design

Recombination amongst clinical isolates as support for the feasibility of genetics

Early successes in genetics

Current genetic tools

Future goals and remaining challenges

Genetics outside C. trachomatis.

Bacteriophage

What we have learned and moving forward

12. Chlamydia Genomics

Sequencing and characteristics of Chlamydiales genomes

Evolutionary dynamics of Chlamydia genomes

Chlamydia evolution during infection: genome sequencing as a tool to scrutinize the host-pathogen 'arms race'

Outlook

13. Chlamydia and Innate Immunity

Innate responses in the body fluid

Interactions with innate immune sensors on the surface and in the cytoplasm of epithelial cells

Signalling and gene expression in response to Chlamydia infection

IFN-γ-induced cell autonomous self-defence mechanisms

Innate immune cells and their role in pathogenesis

Chlamydial subversion of innate immune response

14. Adaptive Immunity to Chlamydia trachomatis Infection

Animal model data tell us what to look for in human studies

CD4 T cells

CD8 T cells

T cell effector mechanisms

The role of B cells

B cells collaborating with T cells

How does it all work and implications for vaccine development: summary

15. Chlamydia Vaccines

Chlamydia pathogens and vaccine status

Current interventions and targets for a human C. trachomatis vaccine

Experience from human and non-human primate trachoma vaccine trials

Correlates of protective immunity

Routes of immunization

Experimental C. trachomatis vaccines

Adjuvants

Delivery systems

Clinical development of a vaccine for C. trachomatis genital infections

Summary and prospects for Chlamydia vaccines

16. Chlamydia Infections and the Microbiota

Vaginal microbiota in genital tract infections with C. trachomatis

Other human chlamydial infections: role of the microbiota?

Chlamydia and microbiota in animals

Outlook.

17. Recent Advances in Epidemiology, Pathology and Immunology of Veterinary Chlamydiae

General overview of veterinary chlamydiae and their importance as pathogens

Zoonotic potential and disease manifestations in humans - an update

Recently described new veterinary chlamydial organisms

Occurrence, structure and possible implications of antimicrobial resistance genes in C. suis

Host-pathogen interactions in C. psittaci infection revealing unique features

Pathology of Chlamydia abortus and Chlamydia pecorum in ruminants

18. Thinking Outside the Chlamydia Box

Introduction: a plea to study environmental chlamydiae

The expanding diversity of the phylum chlamydiae

An expanded capacity for intracellular growth and survival

Chlamydia-related model organisms

19. Animal Models of Chlamydia trachomatis Infection

The pathology of tissue-specific C. trachomatis infections in humans

Non-human primate (NHP) models of C. trachomatis infection

Considerations for choosing the appropriate animal models

Current Books of Interest.

Notes:

Description based on print version record.

Description based on publisher supplied metadata and other sources.

ISBN:

1-912530-29-5

OCLC:

1138028414