Genetic influences on addiction : an intermediate phenotype approach / edited by James MacKillop and Marcus R. Munafò.

Format:

Book

Contributor:

MacKillop, James, 1975- editor.

Munafò, Marcus, 1972- editor.

Language:

English

Subjects (All):

Compulsive behavior--Genetic aspects.

Compulsive behavior.

Substance abuse--Genetic aspects.

Substance abuse.

Phenotype.

Physical Description:

1 online resource (397 p.)

Edition:

1st ed.

Place of Publication:

Cambridge, Massachusetts : The MIT Press, [2013]

Language Note:

English

Summary:

A comprehensive review of research examining intermediary mechanisms to understand the link between genetic variation and addiction liability.Although there is scientific consensus that genetic factors play a substantial role in an individual's vulnerability to drug or alcohol addiction, specific genetic variables linked to risk or resilience remain elusive. Understanding how genetic factors contribute to addiction may require focusing on intermediary mechanisms, or intermediate phenotypes, that connect genetic variation and risk for addiction. This book offers a comprehensive review of this mechanistic-centered approach and the most promising intermediate phenotypes identified in empirical research.The contributors first consider the most established findings in the field, including variability in drug metabolism, brain electrophysiological profiles, and subjective reactions to direct drug effects; they go on to review highly promising areas such as expectancies, attentional processing, and behavioral economic variables; and finally, they investigate more exploratory approaches, including the differential susceptibility hypothesis and epigenetic modifications. Taken together, the chapters offer a macro-level testing of the hypothesis that these alternative, mechanistic phenotypes can advance the understanding of genetic influences on addiction. The book will be of interest to researchers and practitioners in a range of disciplines, including behavioral genetics, psychology, pharmacology, neuroscience, and sociology.ContributorsJohn Acker, Steven R.H. Beach, Gene H. Brody, Angela D. Bryan, Megan J. Chenoweth, Danielle M. Dick, Eske D. Derks, Mary-Anne Enoch, Meg Gerrard, Frederick X. Gibbons, Thomas E. Gladwin, Mark S. Goldman, Marcus Heilig, Kent E. Hutchison, Hollis C. Karoly, Steven M. Kogan, Man Kit Lei, Susan Luczak, James MacKillop, Renee E. Magnan, Leah M. Mayo, Marcus R. Munafo, Daria Orlowska, Abraham A. Palmer, Danielle Pandika, Clarissa C. Parker, Robert A. Philibert, Lara A. Ray, Richard R. Reich, Ronald L. Simons, Courtney J. Stevens, Rachel E. Thayer, Rachel F. Tyndale, Tamara L. Wall, Reinout W. Wiers, Michael Windle, Harriet de Wit

Contents:

An intermediate phenotype approach to addiction genetics / James MacKillop & Marcus R. Munafò

Electrophysiological intermediate phenotypes for the detection of genetic influences on alcoholism / Mary-Anne Enoch

Differential metabolism of alcohol as an intermediate phenotype of risk for alcohol use disorders : alcohol and aldehyde dehydrogenase variants / Tamara L. Wall, Susan Luczak, Daria Orlowska, and Danielle Pandika

Nicotine metabolism as an intermediate phenotype / Meghan J. Chenoweth & Rachel F. Tyndale

Subjective responses to alcohol as an endophenotype : implications for alcoholism etiology and treatment development / Lara A. Ray & Markus Heilig

Subjective drug effects as intermediate phenotypes for substance use / Leah M. Mayo, Abraham A. Palmer, Harriet de Wit

Developmental considerations in gene identification efforts / Danielle M. Dick

Enhancing addiction genetics via behavioral economic intermediate phenotypes / James MacKillop & John Acker

Using FMRI to develop intermediate phenotypes for substance use disorders / Rachel E. Thayer & Kent E. Hutchison

Implicit cognition : an intermediate phenotype for addiction? / Reinout W. Wiers, Thomas E. Gladwin & Eske D. Derks

Role of genetics in addiction and the expectancy principle / Mark S. Goldman & Richard R. Reich

Intermediate phenotypes for alcohol use and alcohol dependence : empirical findings and conceptual issues / Michael Windle

Epigenetic effects as intermediate phenotypes / Beach, S.R.H., Gerrard, M., Brody, G.H., Simons, R.L., Kogan, S. M., Gibbons, F.X., Philibert, R.A.

Differential sensitivity to context : GABRG1 enhances the acquisition of prototypes that serve as intermediate phenotypes for substance use / Ronald L. Simons, Man Kit Lei, Steven R.H. Beach, Gene H. Brody, Robert A. Philibert, Frederick X. Gibbons, Meg Gerrard

From genes to behavior change : treatment response as an intermediate phenotype / Courtney J. Stevens, Hollis C. Karoly, Renee E. Magnan, and Angela D. Bryan

Using intermediate phenotypes to bridge the gap between human and mouse genetics / Clarissa C. Parker & Abraham A. Palmer.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

OCLC-licensed vendor bibliographic record.

ISBN:

9780262314558

026231455X

9780262314541

0262314541

OCLC:

865508690