The dynamic neuron : a comprehensive survey of the neurochemical basis of synaptic plasticity / John Smythies.

Format:

Book

Author/Creator:

Smythies, John R. (John Raymond), 1922-

Language:

English

Subjects (All):

Neuroplasticity.

Neurochemistry.

Physical Description:

1 online resource (viii, 150 pages) : illustrations

Place of Publication:

Cambridge, Mass. : MIT Press, ©2002.

Language Note:

English

Summary:

The traditional model of synapses as fixed structures has been replaced by a dynamic one in which synapses are constantly being deleted and replaced. This book, written by a leading researcher on the neurochemistry of schizophrenia, integrates material from neuroscience and cell biology to provide a comprehensive account of our current knowledge of the neurochemical basis of synaptic plasticity. The book presents the evidence for synaptic plasticity, an account of the dendritic spine and the glutamate synapse with a focus on redox mechanisms, and the biochemical basis of the Hebbian synapse. It discusses the role of endocytosis, special proteins, and local protein synthesis. Additional topics include volume transmission, arachidonic acid signaling, hormonal modulation, and psychological stress. Finally, the book considers pharmacological and clinical implications of current research, particularly with reference to schizophrenia and Alzheimer's disease.

Contents:

Machine generated contents note: Chapter 1

Synaptic Biochemistry 1

1.1 Introduction 1

1.2 Evidencefor Synaptic Plasticity 5

1.3 An Introduction to the Glutamate Synapse and Its Redox-Related

Biochemical Features 6

1.4 Biochemical Factors in Synaptic Plasticity 9

1.5 The Biochemical Basis of the Hebbian Synapse 12

1.6 More Redox Reactions at the Synapse 15

Chapter 2

Endocytosis and Exocytosis 27

2.1 The Role of Endocytosis 27

2.2 Some Enzymes Involved in Endocytosis 35

2.3 Exocytosis 37

2.4 Ubiquitation 38

2.5 The Special Case of Endocytosis in Neurons 40

2.6 The Functional Significance of Membrane and Receptor

Endocytosis 41

Chapter 3

Special Proteins 47

3.1 The Role of Cell Adhesion Molecules 47

3.2 Scaffolding Proteins 55

3.3 Axon Growth-Directing Proteins 60

3.4 Role of Neurotropins 62

3.5 Role of Actin 64

3.6 Role of Local Protein Synthesis 64

Chapter 4

Miscellaneous Items 67

4.1 Volume Transmission and Spillover 67

4.2 Other Neurotransmitters 69

4.3 Arachidonic Acid Signaling 75

4.4 Hormonal Modulation of Synaptic Plasticity 76

4.5 Psychological Stress 76

4.6 Energy 77

4.7 The Role of Astrocytes 77

Chapter 5

Pharmacological Implications and Clinical Applications 79

5.1 Pharmacological Implications 79

5.2 Clinical Applications 80

Chapter 6

Conclusions 91

Appendix A

mRNAs Whose Level Is Altered Following Glutamate Receptor

Stimulation 93

Appendix B

Receptors That Are Endocytosed 97.

Notes:

Includes bibliographical references (pages [107]-143) and index.

"A Bradford book."

OCLC-licensed vendor bibliographic record.

ISBN:

0-262-26467-6

0-262-28398-0

0-585-44259-2

OCLC:

51958073