The clinical use of antipsychotic plasma levels / Jonathan M Meyer, Stephen M Stahl ; with illustrations by Nancy Munter.

Format:

Book

Author/Creator:

Meyer, Jonathan M., 1962- author.

Stahl, Stephen M., 1951- author.

Series:

Stahl's handbooks.

Cambridge medicine (Series)

Stahl's handbooks

Cambridge medicine

Language:

English

Subjects (All):

Antipsychotic drugs.

Physical Description:

1 online resource (xx, 382 pages) : digital, PDF file(s).

Edition:

First edition.

Place of Publication:

Cambridge : Cambridge University Press, 2021.

Summary:

Clinicians recognize that monitoring psychotropic levels provides invaluable information to optimize therapy and track treatment adherence, but they lack formal training specifically focused on the use of plasma antipsychotic levels for these purposes. As new technologies emerge to rapidly provide these results, the opportunity to integrate this information into clinical care will grow. This practical handbook clarifies confusing concepts in the literature on use of antipsychotic levels, providing clear explanations for the logic underlying clinically relevant concepts such as the therapeutic threshold and the point of futility, and how these apply to individual antipsychotics. It offers accessible information on the expected correlation between dosages and trough levels, and also provides a clear explanation of how to use antipsychotic levels for monitoring oral antipsychotic adherence, and methods to help clinicians differentiate between poor adherence and variations in drug metabolism. An essential resource for psychiatrists, psychiatric nurse practitioners, and mental health professionals worldwide.

Contents:

Sampling times for oral and long acting injectable agents

The therapeutic threshold and the point of futility

Level interpretation including laboratory reporting issues, responding to high plasma issues, responding to high plasma levels, special situations (hepatic dysfunction, renal dysfunction and hemodialysis, bariatric surgery)

Tracking oral antipsychotic adherence

What is an adequate antipsychotic trial-using plasma levels to optimize psychiatric response and tolerability

Important concepts about first generation antipsychotics

Haloperidol and haloperidol decanoate

Fluphenazine and fluphenazine decanoate

Perphenazine and perphenazine decanoate

Zuclopenthixol and zuclopenthixol decanoate; flupenthixol and flupenthixol decanoate

Chlorpromazine, loxapine, thiothixene, trifluoperazine

Important concepts about second generation antipsychotics

Clozapine

Risperidone oral and long acting injectable, paliperidone oral and long acting injectable

Olanzapine and olanzapine pamoate

Aripiprazole, aripiprazole monohydrate and aripiprazole lauroxil

Amisulpride, asenapine, lurasidone, brexpiprazole, cariprazine.

Notes:

Title from publisher's bibliographic system (viewed on 20 Oct 2021).

Includes bibliographical references and index.

ISBN:

9781009007511

1009007513

9781009008280

1009008285

9781009002103

1009002104