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Centromere drive and suppression by parallel pathways for recruiting microtubule destabilizers / Tomohiro Kumon.
- Format:
- Book
- Thesis/Dissertation
- Author/Creator:
- Kumon, Tomohiro, author.
- Language:
- English
- Subjects (All):
- Biology.
- Evolution & development.
- Morphology.
- Cellular biology.
- Biophysics.
- Biology--Penn dissertations.
- Penn dissertations--Biology.
- Local Subjects:
- Biology.
- Evolution & development.
- Morphology.
- Cellular biology.
- Biophysics.
- Biology--Penn dissertations.
- Penn dissertations--Biology.
- Genre:
- Academic theses.
- Physical Description:
- 1 online resource (100 pages)
- Contained In:
- Dissertations Abstracts International 83-03B.
- Place of Publication:
- [Philadelphia, Pennsylvania] : University of Pennsylvania ; Ann Arbor : ProQuest Dissertations & Theses, 2021.
- Language Note:
- English
- System Details:
- Mode of access: World Wide Web.
- text file
- Summary:
- Selfish centromere DNA sequences bias their transmission to the egg in female meiosis. Evolutionary theory suggests that centromere proteins evolve to suppress costs of this "centromere drive". In hybrid mouse models with genetically different maternal and paternal centromeres, selfish centromere DNA exploits a kinetochore pathway to recruit microtubule- destabilizing proteins that act as drive effectors. We show that such functional differences are suppressed by a parallel pathway for effector recruitment by heterochromatin, which is similar between centromeres in this system. Disrupting the kinetochore pathway with a divergent allele of CENP-C reduces functional differences between centromeres, whereas disrupting heterochromatin by CENP-B deletion amplifies the differences. Molecular evolution analyses using newly sequenced Murinae genomes identify adaptive evolution in proteins in both pathways. We propose that centromere proteins have recurrently evolved to minimize the kinetochore pathway, which is exploited by selfish DNA, relative to the heterochromatin pathway that equalizes centromeres, while maintaining essential functions.
- Notes:
- Source: Dissertations Abstracts International, Volume: 83-03, Section: B.
- Advisors: Lampson, Michael A.; Committee members: Goulian, Mark; Black, Ben E.; Kim, Junhyong; Levine, Mia.
- Department: Biology.
- Ph.D. University of Pennsylvania 2021.
- Local Notes:
- School code: 0175
- ISBN:
- 9798535591353
- Access Restriction:
- Restricted for use by site license.
- This item must not be sold to any third party vendors.
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