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Lymphocyte egress signal sphingosine-1-phosphate promotes ERM-guided, bleb-based migration / Tanner Ford Robertson.
- Format:
- Book
- Thesis/Dissertation
- Author/Creator:
- Robertson, Tanner Ford, author.
- Language:
- English
- Subjects (All):
- Immunology.
- Cellular biology.
- Biochemistry.
- Immunology--Penn dissertations.
- Penn dissertations--Immunology.
- Local Subjects:
- Immunology.
- Cellular biology.
- Biochemistry.
- Immunology--Penn dissertations.
- Penn dissertations--Immunology.
- Genre:
- Academic theses.
- Physical Description:
- 1 online resource (116 pages)
- Contained In:
- Dissertations Abstracts International 83-02B.
- Place of Publication:
- [Philadelphia, Pennsylvania] : University of Pennsylvania ; Ann Arbor : ProQuest Dissertations & Theses, 2021.
- Language Note:
- English
- System Details:
- Mode of access: World Wide Web.
- text file
- Summary:
- Ezrin, radixin, and moesin (ERM) family proteins regulate cytoskeletal responses by tethering the plasma membrane to the underlying actin cortex. Mutations in ERM proteins lead to severe combined immunodeficiency, but the function of these proteins in T cells remains poorly defined. Using mice in which T cells lack all ERM proteins, we demonstrate a selective role for these proteins in facilitating egress from lymphoid organs in response to sphingosine-1-phosphate (S1P), a pleiotropic signaling lipid abundant in the blood and lymph. ERM-deficient T cells display defective S1P-inducedmigration in vitro, despite normal responses to standard protein chemokines that control entry into and migration within lymphoid organs. Analysis of these defects revealed thatS1P promotes a fundamentally different mode of migration than chemokines, characterized by intracellular pressurization and bleb-based motility. ERM proteins facilitate this process, controlling directional migration by limiting blebbing to the leading edge. We propose that the distinct modes of motility induced by S1P and chemokines are specialized to allow T cell migration across lymphatic barriers and through tissue stroma, respectively.
- Notes:
- Source: Dissertations Abstracts International, Volume: 83-02, Section: B.
- Advisors: Burkhardt, Janis K.; Committee members: Kambayashi, Taku; Marks, Michael S.; Schwartzberg, Pamela L.; Scott, Phillip.
- Department: Immunology.
- Ph.D. University of Pennsylvania 2021.
- Local Notes:
- School code: 0175
- ISBN:
- 9798516948190
- Access Restriction:
- Restricted for use by site license.
- This item must not be sold to any third party vendors.
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