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Innate immunity in degenerative diseases of the retina and brain / Jacob Khan Sterling.
- Format:
- Book
- Thesis/Dissertation
- Author/Creator:
- Sterling, Jacob Khan, author.
- Language:
- English
- Subjects (All):
- Neurosciences.
- Ophthalmology.
- Molecular biology.
- Neurodegeneration.
- Parkinsons disease.
- Macular degeneration.
- Rodents.
- Neuroscience--Penn dissertations.
- Penn dissertations--Neuroscience.
- Local Subjects:
- Neurosciences.
- Ophthalmology.
- Molecular biology.
- Neurodegeneration.
- Parkinsons disease.
- Macular degeneration.
- Rodents.
- Neuroscience--Penn dissertations.
- Penn dissertations--Neuroscience.
- Genre:
- Academic theses.
- Physical Description:
- 1 online resource (108 pages)
- Contained In:
- Dissertations Abstracts International 83-03B.
- Place of Publication:
- [Philadelphia, Pennsylvania] : University of Pennsylvania ; Ann Arbor : ProQuest Dissertations & Theses, 2021.
- Language Note:
- English
- System Details:
- Mode of access: World Wide Web.
- text file
- Summary:
- Innate immunity plays a critical role in degenerative diseases of the central nervous system (CNS). However, many of the molecular pathways by which innate inflammation contributes to individual diseases remain unknown. Herein, we use a combination of primary cell culture, in vivo animal studies and human data to explore two distinct pathways of neuroinflammation. The first, focuses on the role of reactive astrocytes as mediators of innate inflammation and neurodegeneration in glaucoma. The second, highlights the role of nutritional immunity, a division of the innate immune system, in iron dysregulation observed across multiple CNS diseases including age-related macular degeneration and Parkinson's disease. Together these data highlight the multiple mechanisms by which maladaptive activation of innate immunity can contribute to CNS dysfunction and identify new targets for therapeutic intervention.
- Notes:
- Source: Dissertations Abstracts International, Volume: 83-03, Section: B.
- Advisors: Cui, Qi N.; Dunaief, Joshua L.; Committee members: Bennett, Jean; Mitchell, Claire ; Pierce, Eric; Ross, Ahmara; Bennett, Frederick.
- Department: Neuroscience.
- Ph.D. University of Pennsylvania 2021.
- Local Notes:
- School code: 0175
- ISBN:
- 9798535568911
- Access Restriction:
- Restricted for use by site license.
- This item is not available from ProQuest Dissertations & Theses.
- This item must not be sold to any third party vendors.
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