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Mathematical modeling of cell migration / Maria Jesus Munoz Lopez.
- Format:
- Book
- Thesis/Dissertation
- Author/Creator:
- Lopez, Maria Jesus Munoz, author.
- Language:
- English
- Subjects (All):
- Applied mathematics.
- Mathematics.
- Cytoplasm.
- Simulation.
- Behavior.
- Cell adhesion & migration.
- Experiments.
- Lymphatic system.
- Binding sites.
- Approximation.
- Numerical analysis.
- Travel.
- Antigens.
- Ablation.
- Motility.
- Proteins.
- Applied mathematics and computational science--Penn dissertations.
- Penn dissertations--Applied mathematics and computational science.
- Local Subjects:
- Applied mathematics.
- Mathematics.
- Cytoplasm.
- Simulation.
- Behavior.
- Cell adhesion & migration.
- Experiments.
- Lymphatic system.
- Binding sites.
- Approximation.
- Numerical analysis.
- Travel.
- Antigens.
- Ablation.
- Motility.
- Proteins.
- Applied mathematics and computational science--Penn dissertations.
- Penn dissertations--Applied mathematics and computational science.
- Genre:
- Academic theses.
- Physical Description:
- 1 online resource (126 pages)
- Contained In:
- Dissertations Abstracts International 83-03B.
- Place of Publication:
- [Philadelphia, Pennsylvania] : University of Pennsylvania ; Ann Arbor : ProQuest Dissertations & Theses, 2021.
- Language Note:
- English
- System Details:
- Mode of access: World Wide Web.
- text file
- Summary:
- Cell migration is an essential process, involved in immune defense, cancer spread, wound healing, and embryo development. This work presents modeling efforts to understand various mechanisms of cell migration. We first discuss the modeling of bleb-driven cell migration, where the cell membrane detaches from the cytoskeleton and generates a protrusion that is completely devoid of structural proteins. Cell migration in this case is driven essentially by pressure and motor contractility exerted by myosin. I will introduce a stochastic model of bleb-driven migration offering support for theories on blebbing cell polarization and the potential involvement of water channels. We then turn to the involvement of ion channels and ionic electrodiffusion in cell processes, first in cell volume control, and then in cell migration, presenting a model that combines electrodiffusion-driven migration with a mechanical model of actin polymerization.
- Notes:
- Source: Dissertations Abstracts International, Volume: 83-03, Section: B.
- Advisors: Mori, Yoichiro; Committee members: Mori, Yoichiro; Katifori, Eleni ; Shenoy, Vivek.
- Department: Applied Mathematics and Computational Science.
- Ph.D. University of Pennsylvania 2021.
- Local Notes:
- School code: 0175
- ISBN:
- 9798535591049
- Access Restriction:
- Restricted for use by site license.
- This item must not be sold to any third party vendors.
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