Bioinformatics : methods and applications / edited by Dev Bukhsh Singh and Rajesh Kumar Pathak.

Format:

Book

Language:

English

Subjects (All):

Bioinformatics.

Genre:

Electronic books.

Physical Description:

1 online resource

Place of Publication:

[Place of publication not identified] : Academic Press, 2021.

System Details:

text file

Contents:

Front Cover

Bioinformatics

Copyright Page

Contents

List of contributors

Preface

1 Introduction to basics of bioinformatics

1.1 Introduction

1.1.1 Concept behind bioinformatics, in silico biology, and computational biology

1.1.2 Scientific discipline and support systems for bioinformatics

1.1.3 Needs of bioinformatics

1.2 Historical background of bioinformatics

1.3 Aim of bioinformatics

1.4 The recent development in the field of bioinformatics

1.5 Challenges in bioinformatics

1.6 Application of bioinformatics

1.6.1 Sequence analysis

1.6.2 Phylogenetic analysis

1.6.3 Prediction of protein secondary structure

1.6.4 Protein 3D structure prediction

1.6.5 Evaluation and validation of predicted protein model

1.6.6 Discovery and designing of small molecules leading to drugs/agrochemical development

1.6.7 Next-generation sequencing data analysis

1.6.8 SNP and SSR identification

1.6.9 Pharmacogenomics

1.6.10 Metabolomics and metabolic flux analysis

1.6.11 Systems biology and omics data integration

1.7 Future perspective

1.8 Conclusion

Conflict of interest

References

2 Biological databases and their application

2.1 Introduction

2.1.1 Relational databases

2.1.2 Object-oriented databases

2.1.2.1 It stores the biological data in computer-readable form

2.1.2.2 The stored data should be accessed efficiently

2.1.2.3 Biological data should be available to the research community in a single place

2.2 Sequence databases

2.2.1 GenBank

2.2.2 European Nucleotide Archive

2.2.3 DNA Database of Japan

2.2.4 GenPept

2.2.5 Protein information resources

2.3 Composite database

2.3.1 Universal Protein Resource (UniProt)

2.3.1.1 UniProtKB

2.3.1.2 UniRef

2.3.1.3 UniParc

2.3.2 Nonredundant database

2.4 Secondary database

2.4.1 PROSITE

2.4.2 PRINTS

2.4.3 Pfam

2.4.4 InterPro

2.5 Structural databases

2.5.1 Research collaboratory for structural bioinformatics protein data bank

2.5.2 SCOP

2.5.3 CATH/Gene3D

2.6 Specialized database

2.6.1 Clustering databases

2.6.2 Bibliographic databases

2.6.3 Expression databases

2.6.4 Taxonomy databases

2.6.5 Interaction databases

2.6.6 Pathway databases

2.6.7 Enzyme databases

2.6.8 microRNA database

2.6.9 Small molecule database

2.6.10 Vaccine design database

2.7 Database searching and annotation

2.7.1 Entrez

2.7.2 The sequence retrieval system

2.7.3 Annotation

2.8 Conclusions

References

3 Biological sequence analysis

3.1 Introduction

3.2 Sequence alignments: determining similarity and deducing homology

3.2.1 Why construct sequence alignment?

3.2.2 Similarity of sequences

3.2.3 Homology of sequences

3.2.4 Global sequence alignment

3.2.5 Local sequence alignment

3.2.6 Working of alignment algorithm

Other Format:

ebook version :

ISBN:

9780323900058

0323900054

OCLC:

1280391907

Access Restriction:

Restricted for use by site license.