Guideline for the pharmacological treatment of hypertension in adults / World Health Organization.

Format:

Book

Author/Creator:

World Health Organization, issuing body.

Language:

English

Subjects (All):

Hypertension.

Physical Description:

1 online resource (ix, 48 pages) : illustrations

Edition:

1st ed.

Place of Publication:

Geneva : World Health Organization, [2021]

Summary:

In this guideline, the World Health Organization (WHO) provides the most current and relevant evidence-based global public health guidance on the initiation of treatment with pharmacological agents for hypertension in adults. The recommendations target adult, non-pregnant patients who were appropriately diagnosed with hypertension and counselled about life-style modifications. The guideline provides new recommendations on the threshold for the initiation of pharmacological treatment for hypertension, as well as recommendations on intervals for follow up, target blood pressure to be achieved for control, and the cadre of health care workers who may initiate treatment. The guideline provides the basis for deciding whether to initiate treatment with monotherapy, dual therapy or single-pill combinations, as well as guidance for countries selecting medicines and algorithms for hypertension control for their national guidelines for hypertension management.

Contents:

Intro

Acknowledgements

Acronyms and abbreviations

Executive summary

1 Introduction

2 Method for developing the guideline

2.1 Guideline contributors

2.2 Analytical framework and PICOs

2.3 Outcome importance rating

2.4 Reviews of evidence

2.5 Certainty of evidence and strength of recommendations

2.6 Deciding upon recommendations

2.7 Funding

3 Recommendations

3.1 Blood pressure threshold for initiation of pharmacological treatment

3.2 Laboratory testing before and during pharmacological treatment

3.3 Cardiovascular disease risk assessment as guide to initiation of antihypertensive medications

3.4 Drug classes to be used as first-line agents

3.5 Combination therapy

3.6 Target blood pressure

3.7 Frequency of re-assessment

3.8 Administration of treatment by nonphysician professionals

4 Special settings

4.1 Hypertension in disaster, humanitarian and emergency settings

4.2 COVID-19 and hypertension

4.3 Pregnancy and hypertension

5 Publication, implementation, evaluation and research gaps

5.1 Publication

5.2 Implementation and dissemination

5.3 Evaluation

5.4 Future updating of the guideline

5.5 Research gaps

6 Implementation tools

6.1 Guideline recommendations

6.2 Drug- and dose-specific protocols

References

Annex 1: List of contributors

Annex 2. Managing declarations of interest and conflicts of interest

Annex 3: Treatment outcomes relevant to hypertension

Annex 4: PICO questions

Fig. 1 Analytic framework for antihypertensive medication treatment

Fig. 2 Framework for analysis

Fig. 3 An approach for starting treatment with a single-pill combination

Fig. 4 An approach for starting treatment not using a single-pill combination (i.e. with monotherapy or free combination therapy)

Fig. 5 Algorithm 1

Fig. 6 Algorithm 2.

Fig. A3.1 Rating of outcomes

_GoBack.

Notes:

Includes bibliographical references.

Description based on: online resource; title from PDF information screen (NCBI, viewed November 3, 2022).