Coeliac disease and gluten-related disorders edited by Annalisa Schiepatti, David S. Sanders

Format:

Book

Contributor:

Schiepatti, Annalisa, editor.

Sanders, David, 1968- editor.

Language:

English

Subjects (All):

Celiac disease.

Celiac Disease--therapy.

Celiac Disease.

Medical Subjects:

Celiac Disease--therapy.

Celiac Disease.

Physical Description:

1 online resource

Place of Publication:

London, United Kingdom Academic Press [2022]

Summary:

Coeliac Disease and Gluten-Related Disorders provides an updated and comprehensive overview on the crucial aspects and clinical management of gluten-related disorders. It provides an overview of the scientific background, mechanisms involved, and emphasizes the translational effect of research on clinical practice. Highlighted throughout are insights into future research areas likely to have a crucial impact in the clinical management of these common conditions. The book is perfect for researchers and gastroenterologists involved in Coeliac Disease and other gluten-related disorders

Contents:

Front cover

Half title

Title

Copyright

Contents

Contributors

Chapter 1 Epidemiology and clinical features of celiac disease in adults

1.1 Introduction

1.2 Initial epidemiological studies based on clinical symptoms

1.3 Modern epidemiological study based on the serological test

1.4 Global prevalence of CeD

1.5 Global seroprevalence of CeD

1.6 Global prevalence of biopsy-confirmed CeD

1.7 Prevalence of CeD by gender and age

1.8 Continent wise prevalence of CeD

1.8.1 CeD in Europe

1.8.2 Celiac disease in America (North and South America)

1.8.3 Prevalence of CeD in Oceania

1.8.4 Prevalence of CeD in Africa

1.8.5 Prevalence of CeD in Asia

1.8.6 Increase in the global prevalence of CeD over time

1.8.7 Increase in the incidence of CeD

1.8.8 Spectrum of clinical manifestations of CeD

1.8.9 Gastrointestinal manifestations (Classical CeD)

1.9 Extra-intestinal manifestations of CeD (Table 1.2 and Table 1.3)

1.9.1 Hematological manifestations

1.9.2 Endocrinological manifestations

1.9.3 Skeletal manifestations (osteopenia and osteoporosis)

1.9.4 Hepatic manifestations

1.9.5 Metabolic manifestations

1.9.6 Dermatological manifestations

1.9.7 Reproductive manifestations

1.9.8 Neuropsychiatric manifestations

1.9.9 Oral cavity and dental manifestations

1.10 Mortality in celiac disease

References

Chapter 2 Pediatric coeliac disease

2.1 Introduction: Distinct features of pediatric coeliac disease

2.2 Clinical presentation

2.3 Diagnosis

2.4 Screening of children for coeliac disease

2.5 Treatment and monitoring of paediatric coeliac disease

2.6 Toward primary prevention of coeliac disease?

2.7 Summary

Chapter 3 Pathogenesis of coeliac disease

a disorder driven by gluten-specific CD4+ T cells

3.1 Inductive and effector sites within the gut immune system

3.2 Induction of adaptive immune response to gluten

3.2.1 Involvement HLA II molecules

3.2.2 Transglutaminase 2 in CeD

3.2.3 Gluten: The driver of T-cell response

3.2.4 Gluten trafficking from lumen to lamina propria

3.2.5 Antigen presenting cells in the lamina propria presenting gluten

3.3 Gluten-specific CD4+ T cells

3.3.1 HLA-DQ:gluten tetramers

3.3.2 TCR recognition of gluten

3.3.3 Molecular mimicry between gluten T-cell epitopes and bacterial peptides

3.4 Functional role of gluten-specific CD4+ T cells

3.4.1 Phenotype of gluten-specific CD4+ T cells

3.4.2 Cytokine production

3.4.3 T cell and B cell interaction: Antibody production and T-cell clonal expansion

3.4.4 CD4+ T-cell help to intraepithelial lymphocytes (IELs)

3.4.5 Mechanisms underlying villous blunting in CeD

3.5 Concluding remarks

Chapter 4 Seronegative villous atrophy

4.1 Introduction

4.2 Seronegative coeliac disease

4.3 Immunomediated non-coeliac enteropathies

4.3.1 Autoimmune enteropathy

4.3.2 Enteropathy associated to common variable immunodeficiency

4.3.3 Iatrogenic forms of villous atrophy

4.4 Enteropathies due to infectious causes

4.5 Lymphoproliferative disorders causing villous atrophy

4.6 Villous atrophy due to inflammatory disorders

4.7 Idiopathic villous atrophy

4.8 Methodological approach to differential diagnosis and management of seronegative villous atrophy

4.8.1 Principles of management of seronegative villous atrophy

4.9 Conclusions

Chapter 5 Nonresponsive and complicated coeliac disease

5.1 Introduction

5.2 Dietary indiscretion and mucosal healing

5.3 An alternative pathology

5.4 Refractory coeliac disease

5.4.1 Treatment in refractory coeliac disease

8.1.1 Prevalence and incidence of dermatitis herpetiformis

8.1.2 Gender and age at onset in dermatitis herpetiformis

8.2 Pathogenesis of dermatitis herpetiformis: from gut to skin

8.3 Clinical features of dermatitis herpetiformis

8.4 Diagnosis of dermatitis herpetiformis

8.4.1 Skin and small bowel biopsy findings

8.4.2 Serum coeliac antibody measurements

8.4.3 Diagnostic work-up of dermatitis herpetiformis

8.5 Treatment of dermatitis herpetiformis

8.5.1 Gluten-free diet

8.5.2 Dapsone

8.6 Long-term prognosis of dermatitis herpetiformis

8.7 Concluding remarks

Chapter 9 Noncoeliac gluten sensitivity

9.1 Introduction

9.2 The clinical picture

9.3 IBS

NCGS

or both?What can be learned from RCTs?

9.4 The gluten-free market

9.5 Immunobiology of gluten in NCGS (and CD)

9.6 The possible culprits

9.7 Serological and genetic markers

9.8 Clinical investigation

the view of the clinical dietician

9.9 The FODMAP approach

9.10 Summary

Chapter 10 Pediatric noncoeliac gluten sensitivity

10.1 Introduction

10.2 Definition and epidemiology of NCGS/NCWS in children

10.3 Clinical features and diagnosis of NCGS/NCWS in children

10.3.1 Clinical features in adults and children

10.3.2 Diagnosis of NCGS/NCWS

10.3.3 Serological features of NCGS/NCWS in children

10.4 Histological features of NCGS/NCWS in children

10.5 Therapeutic approach to NCGS/NCWS in children

10.6 Conclusion

Chapter 11 Neurological manifestations of gluten-related disorders

11.1 Introduction

11.2 Gluten ataxia

11.3 Gluten neuropathy

11.4 Gluten encephalopathy

11.5 Epilepsy

11.6 Gluten myopathy

11.7 Pathophysiology

11.8 Conclusions

References

Chapter 12 The role of gluten in multiple sclerosis, psoriasis, autoimmune thyroid diseases and type 1 diabetes

12.1 Introduction

12.2 Gluten

12.3 Multiple sclerosis

12.3.1 Celiac disease and multiple sclerosis

12.3.2 Can patients with multiple sclerosis benefit from a gluten-free diet?

12.4 Psoriasis

12.4.1 Celiac disease and psoriasis

12.4.2 Gluten-related antibodies as markers of disease activity in psoriasis

12.4.3 Can gluten intake affect the risk of psoriasis?

12.4.4 Can patients with psoriasis benefit from a gluten-free diet?

12.5 Autoimmune thyroid diseases

12.5.1 Celiac disease and autoimmune thyroid diseases

12.5.2 Gluten-related antibodies as markers of disease activity in autoimmune thyroid diseases

12.5.3 Can patients with autoimmune thyroid diseases benefit from a gluten-free diet?

12.6 Type 1 diabetes

12.6.1 Celiac disease and type 1 diabetes

12.6.2 Can gluten intake affect the risk of Type 1 Diabetes?

12.6.3 Can patients with type 1 diabetes benefit from a gluten-free diet?

12.7 Concluding remarks

Chapter 13 Irritable bowel syndrome

13.1 Introduction

13.2 Gluten free diet

13.2.1 Nutritional adequacy

13.2.2 Microbiota

13.2.3 Wheat components

13.2.4 Long term outcomes

13.2.5 Adherence

13.3 Low FODMAP diet

13.3.1 Nutritional adequacy

13.3.2 Microbiota

13.3.3 Adherence

13.3.4 Efficacy versus other dietary and nondietary therapies

13.4 Traditional dietary advice

13.5 Challenges of dietary studies

13.6 Choice of dietary therapy

13.7 Conclusion

Index

Back cover

Notes:

Includes bibliographic references and index

Other Format:

Print version:

ISBN:

9780128215722

0128215720

OCLC:

1276848665

Access Restriction:

Restricted for use by site license