Proteolytic signaling in health and disease edited by André Zelanis

Format:

Book

Contributor:

Zelanis, André, editor.

Language:

English

Subjects (All):

Proteolytic enzymes.

Physical Description:

1 online resource

Place of Publication:

London, UK Academic Press [2022]

Summary:

"Examines biological events triggered by proteolytic enzyme activity across human development and pathologies Discusses the role of proteolytic signaling in inflammation, wound healing, and cancer, among other disease types Features methods and protocols supporting further study of proteolytic signaling events Includes chapter contributions from international leaders in the field"-- Provided by publisher

Contents:

Cardiovascular alterations

Cancer

Other pathological processes

Conclusions

Abbreviations used in this chapter

References

Chapter 5 Proteolytic processing in autophagy

Autophagy in health and disease

Inducing-autophagy proteases

Cysteine cathepsin inhibitors and the autophagic process

Inhibiting-autophagy proteases

Conclusion remarks and perspectives

Chapter 6 Proteases are cut out to regulate acute and chronic inflammation

Introduction to inflammation

Cytokines

Chemokines

The roles of proteases in sepsis

The roles of proteases in Crohn's disease

Chapter 7 Proteolytic processing of laminin and the role of cryptides in tumoral biology

Laminin

Laminin-111 cryptides

YIGSR (YIGSR, short arm of beta1 chain)

IKVAV (IKVAV, long arm of alpha1 chain)

AG73 (RKRLQVQLSIRT, LG4 domain of alpha1 chain)

C16 (KAFDITYVRLKF, gamma1 chain)

Conclusion

Chapter 8 Proteolytic signaling in cutaneous wound healing

Introduction

Wound healing phases

Phase I: Hemostasis

Phase II: Inflammation

Phase III: Proliferation

Phase IV: Remodeling

Wound healing disruption and chronicity

Proteases

Serine proteases

Coagulation cascade

Anticoagulant signaling and fibrinolysis

Neutrophil proteases, tissue kallikreins, and complement system

Metalloproteases

Matrixins

Adamalysins and astacins

Cysteine proteases

Cathepsins

Exogenous proteases

Chapter 9 Proteinase imbalance in oral cancer and other diseases

Proteolysis in oral cancer

Overview on proteolysis

Proteinases and inhibitors in oral cancer

Saliva peptidomics in oral cancer

Zinc metalloproteinases: A family of proteinases involved in the balance between health and disease

Adam17

ADAM17 history

ADAM17 structure and biological function

ADAM17 in development, inflammation, and cancer

ADAM17: A potential therapeutic biomarker

ADAM17: Employing different tools to study the mechanism of regulation in health and disease

ADAM17 catalytic site-dependent regulation

ADAM17 regulation at the substrate level

ADAM17 regulation by novel uncovered substrates in OSCC

ADAM17 regulation at the maturation level

ADAM17 role as a potential therapeutic target

ADAM17 noncatalytic site-dependent regulation

ADAM17 regulation by inside-outside cross talk promoted by the cytoplasmic domain

Direct and indirect effect of thiol-isomerase on ADAM17 activity

ADAM17 effect on thiol isomerase activity and protein dimeric conformation

Perspectives and conclusions

Acknowledgments

Chapter 10 "Omics" approaches to determine protease degradomes in complex biological matrices

Experimental design for protease degradome profiling

Substrate discovery with recombinant proteases in vitro

Modulation of protease abundance in cell culture

Modulation of protease activity in vivo

Quantitative bottom-up proteomics

Data-dependent acquisition of peptide fragment spectra

Improved quantification by targeted mass spectrometry

Data-independent acquisition of peptide fragment spectra

Protease substrate discovery by quantitative shotgun proteomics

Selective enrichment and proteome-wide characterization of protein termini

Enrichment of protein N-termini

Enrichment of protein C-termini

Positional proteomics data analysis

Peptidomics

Chapter 11 The protease web

Classification systems of proteases

Regulation of protease activity by proteases

Regulation of protease activity by protease inhibitor proteins

Conceptualization of the protease web

Network biology and the protease web

Introduction to network biology

Network models of the protease web reveal structural properties

Prediction of novel proteolytic pathways in the protease web

Data and databases of protease interactions

Identification of protease interactions

Outlook

Acknowledgment

Chapter 12 The puzzle of proteolytic effects in hemorrhage induced by Viperidae snake venom metalloproteinases

Overview of snakebite envenomation

Snakebite envenomation epidemiology

Brief overview of medically relevant venomous snakes

Clinical manifestations of snakebites: Envenomation symptoms

Snake venom metalloproteinases related to hemorrhagic effects

Tissue effects and mechanisms evolving SVMP in hemorrhage

Cell effects and signaling events that might be evolved in the hemorrhage induced by SVMPs

Non-catalytic domains involved in SVMPs effects: DC domain

Therapeutic strategies targeting hemostatic disturbance of snake venoms: Antivenoms and new therapies

Molecules from natural products as alternative therapy methods for snake envenoming local effects

Small molecule inhibitors as alternative therapy methods

Conclusions remarks

Index

Notes:

Print version record

Other Format:

Print version Proteolytic signaling in health and disease

ISBN:

9780323856973

0323856977

OCLC:

1276847877

Access Restriction:

Restricted for use by site license