Enzymes involved in glycolysis, fatty acid and amino acid biosynthesis : active site mechanisms and inhibition / authored by Marco Brito-Arias.

Format:

Book

Author/Creator:

Brito Arias, Marco Augusto, author.

Language:

English

Subjects (All):

Glycolysis.

Amino acids.

Enzymes--Synthesis.

Enzymes.

Physical Description:

1 online resource (334 pages)

Edition:

1st ed.

Place of Publication:

Singapore : Bentham Science Publishers Pte Ltd., [2020]

Summary:

Multidisciplinary research involving crystallography, kinetic studies, molecular docking, genetics and other techniques in biochemistry has yielded a wealth of knowledge about the reaction mechanisms in cellular processes. This knowledge has allowed researchers to understand, in a better way, the normal functioning of the cell process, which is used as a reference point for learning about and preventing or correcting pathologies that cause diseases.This enzymology reference is a thorough compendium about reaction mechanisms occurring between the major enzymes related to the biosynthetic pathways of 3 important types of biological compounds - 6-carbon carbohydrates, fatty acids and amino acids - and their substrates, cofactors and residues. Readers will gain an understanding of the interaction between substrates or ligands with specific amino acid residues in biosynthetic enzymes. This understanding builds a foundation for learning about the biochemistry of different inhibitors used in the treatment of several diseases such as cancer, infectious diseases, and metabolic syndrome alterations such as diabetes and obesity.Enzymes covered in the book include aldolases, isomerases, kinases, mutases, synthases, dehydrogenases, reductases, transferases, hydrolases, lyases among others, all of which are wide spread in biochemical transformations. This reference, with its insights on common biochemical enzymes serves as a handy guide for students, researchers and professionals involved academia or industry related to pharmaceutical development, healthcare, food chemistry and other disciplines.

Contents:

Cover

Title

Copyright

End User License Agreement

Contents

Preface

ACKNOWLEDGEMENTS:

CONFLICT OF INTEREST:

Glycolysis

1. ENZYMES AND THEIR INHIBITORS INVOLVED IN THE GLYCOLYSIS PATHWAY

1.1. Hexokinase (HK)

1.2. Hexokinase Inhibitors

1.3. Phosphoglucose Isomerase (PGI)

1.4. Phosphoglucose isomerase Inhibitors

1.5. Phosphofructokinase (PFK)

1.6. Phosphofructokinase (PFK) Inhibitors

1.7. Fructose Biphosphate Aldolase (FBP Aldolase)

1.8. Fructose Biphosphate Aldolase Inhibitors

1.9. Triosephosphate Isomerase (TIM)

1.10. Triosephosphate Isomerase (TPI) Inhibitors

1.11. Glyceraldehyde Phosphate Dehydrogenase (GAPDH)

1.12. Glyceraldehyde Phosphate Dehydrogenase (GAPDH) Inhibitors

1.13. Phosphoglycerate Kinase (PGK)

1.14. Phosphoglycerate Kinase Inhibitors

1.15. Bisphosphoglycerate Mutase (BPGM)

1.16. Phosphoglycerate Mutase (PGM)

1.17. Phosphoglycerate Mutase Inhibitors

1.18. Enolase (ENO)

1.19. Enolase Inhibitors

1.20. Pyruvate Kinase (PK)

1.21. Piruvate Kinase Inhibitors

Citric Acid Cycle (Krebs)

1. ENZYMES INVOLVED IN THE CITRIC ACID CYCLE

1.1. Citrate Synthase (CS)

1.2. Citrate Synthase Inhibitors

1.3. Aconitase (Citrate-isocitrate Hydroxylase)

1.4. Aconitase Inhibitors

1.5. Isocitrate Dehydrogenase (IDH)

1.6. Isocitrate Dehydrogenase Inhibitors

1.7. α-Keto Glutarate Dehydrogenase (KGD)

1.8. α-Keto Glutarate Dehydrogenase Inhibition

1.9. Succinyl-CoA Synthetase or Succinyl-CoA Ligase

1.10. Succinyl-CoA Synthetase Inhibitors

1.11. Succinate Dehydrogenase (SDH) or Succinate-coenzyme Q Reductase (SQR)

1.12. Succinate Dehydrogenase Inhibitors

1.13. Fumarate Hydratase or Fumarase

1.14. Fumarate Hydratase Inhibitors

1.15. Malate Dehydrogenase (MDH)

1.16. Malate Dehydrogenase Inhibitors

Fatty Acid Biosynthesis.

1. ENZYMES INVOLVED IN THE LIPOGENESIS

1.1. Pyruvate Dehydrogenase Complex (PDC)

1.2. Pyruvate Dehydrogenase Inhibitors

1.3. Citrate Synthase (CS)

1.4. Citrate Synthase Inhibitors

1.5. ATP-citrate Lyase (ACLY)

1.6. ATP-citrate Lyase Inhibitors

1.7. Ketoacyl Synthase (KAS)

1.8. Ketoacyl Synthase Inhibitors

1.9. Stearoyl-CoA Desaturase (SCD)

1.10. Stearoyl-CoA Desaturase (SCD) Inhibitors

2. SYSTHESIS OF TRIACYLGLYCEROL (TRIGLYCERIDES)

2.1. Glycerol Kinase (GLPK)

2.2. Glycerol Kinase Inhibitors

2.3. Glycerol-3-phosphate Acyltransferase (GPAT)

2.4. Glycerol-3-phosphate Acyltransferase (GPAT) Inhibitors

2.5. Acylglycerophosphate Acyltransferase (AGPAT or LPAAT)

2.6. Acylglycerophosphate Acyltransferase Inhibitors

2.7. Phosphatidic Acid Phosphohydrolase (PAP)

2.8. Phosphatidic Acid Phosphohydrolase Inhibitors

2.9. Diacylglycerol Acyltransferase (DGAT)

2.9. Diacylglycerol Acyltransferase Inhibitors

2.10. The Kennedy Pathway

Aminoacid Biosynthesis

1. GLYCINE BIOSYNTHESIS

1.1. Serine Hydroxyl Methyl Transferase (SHMT)

1.2. Serine Hydroxymethyl Transferase Inhibitors

2. ALANINE BIOSYNTHESIS

2.1. Pyridoxamine-pyruvate Aminotransferase (PPAT)

2.2. Pyridoxamine-pyruvate Aminotransferase Inhibitors

3. VALINE BIOSYNTHESIS

3.1. Acetohydroxyacid Synthase (AHAS)

3.2. Acetohydroxyacid Synthase Inhibitors

3.3. Ketol-acid Reductoisomerase (KARI)

3.4 Ketol-Acid Reductoisomerase Inhibitors

3.5 Dihydroxy Acid Dehydratase (DAD)

3.6. Dihydroxy Acid Dehydratase Inhibitors

3.7. Branched Chain Amino Acid Aminotransferase (BCAT)

3.8. Branched Chain Amino Acid Aminotransferase Inhibitors

4. LEUCINE BIOSYNTHESIS

4.1. α-Isopropylmalate Synthase (IPMS)

4.2. α-Isopropylmalate Synthase Inhibition

4.3. α-Isopropylmalate Isomerase (IPMI).

4.4. α-Isopropylmalate Isomerase Inhibitors

4.5. α-Isopropylmalate Dehydrogenase (IPMD)

4.6. α-Isopropylmalate Dehydrogenase Inhibition

5. ISOLEUCINE BIOSYNTHESIS

6. PHENYLALANINE BIOSYNTHESIS

6.1. 3-Deoxy-D-Arabinoheptulosonate 7-Phosphate Synthase (DAHPS)

6.2. Dehydroquinate Synthase (DHQS)

6.3. Dehydroquinate Synthase Inhibitors

6.4. Dehydroquinate Dehydratase (DHQD)

6.5. Dehydroquinate Dehydratase Inhibitors

6.6. Shikimate Dehydrogenase (SD)

6.7. Shikimate Dehydrogenase Inhibitors

6.8. Shikimate Kinase (SK)

6.9. Shikimate Kinase Inhibitors

6.10. Enolpyruvisylshikimate Phosphate Synthase (EPSP)

6.11. Enolpyruvisylshikimate Phosphate Synthase Inhibitors

6.12. Chorismate Synthase (CS)

6.13. Chorismate Synthase Inhibitors

6.14. Chorismate Mutase (CM)

6.15. Chorismate Mutase Inhibitors

6.16. Prephenate aminotransferase (PAT)

6.17. Prephenate Aminotransferase Inhibitors

6.18. Arogenate Dehydratase (ADT)

7. TYROSINE BIOSYNTHESIS

7.1. Arogenate Dehydrogenase (ADH)

8. SERINE BIOSYNTHESIS

8.1. Phosphoglycerate Dehydrogenase (PGDH)

8.2. Phosphoglycerate Dehydrogenase Inhibitors

8.3. Phosphoserine Aminotransferase (PSAT)

8.4. Phosphoserine Aminotransferase Inhibitors

8.5. Phosphoserine Phosphatase (PSP)

8.6. Phosphoserine Phosphatase Inhibitors

9. THREONINE BIOSYNTHESIS

9.1. Aspartate Kinase (AK)

9.1.1. Catalytic Domain Regulatory Domain

9.2. Aspartate Kinase Inhibitors

9.3. Aspartate-β-Semialdehyde Dehydrogenase (ASD)

9.4. Aspartate-β-Semialdehyde Dehydrogenase Inhibitors

9.5. Homoserine Dehydrogenase (HSD)

9.6. Homoserine Dehydrogenase Inhibitors

9.7. Homoserine Kinase (HSK)

9.8. Homoserine Kinase Inhibitors

9.9. Threonine Synthase (TS)

9.10. Threonine Synthase Inhibitors

10. CYSTEINE BIOSYNTHESIS.

10.1. Serine Acetyltransferase (SAT)

10.2. Serine Acetyltransferase Inhibitors

10.3. O-acetylserine sulfhydrylase (OASS)

10.4. O-acetylserine Sulfhydrylase Inhibitors

10.5. Methionine Adenosy Transferase (MAT)

10.6. Methionine Adenosy Transferase Inhibitors

10.7. S-adenosyl homocysteine hydrolase (SAH)

10.8. S-Adenosyl Homocysteine Hydrolase Inhibitors

10.9. Cystathionine-β-Synthase (CBS)

10.10. Cystathionine-β-Synthase Inhibitors

10.11. Cystathionine Gamma-Lyase (CGL)

10.12. Cystathionine Gamma-Lyase Inhibitors

10.13. Cysteine Deoxygenase (CDO)

10.14. Cysteine Sulfinic Acid Decarboxylase (CSAD)

10.15. Cysteine Sulfinic Acid Decarboxylase Inhibitors

11. Tryptophan Biosynthesis

11.1. Anthranilate Synthase (AS)

11.2. Anthranilate Synthase Inhibitors

11.3. Anthranilate Phosphoribosyl Transferase (ANPRT)

11.4. Anthranilate Phosphoribosyl Transferase Inhibitors

11.5. Phosphoribosyl Antranilate Isomerase (PRAI)

11.6. Phosphoribosyl Anthranilate Isomerase Inhibitors

11.7. Indole Glycerol Phosphate Synthase (IGPS)

11.8. Indole Glycerol Phosphate Synthase Inhibitors

11.9. Tryptophan Synthase (TS)

11.10. Tryptophan Synthase Inhibitors

12. HISTIDINE BIOSYNTHESIS

12.1. ATP Phosphoribosyl Transferase (HISG)

12.2. ATP Phosphoribosyl Transferase Inhibitors

12.3. Phosphoribosyl-ATP Pyrophosphohydrolase (HISE)

12.4. Phosphoribosyl-ATP Pyrophosphohydrolase Inhibitors

12.5. Phosphoribosyl-Amp Cyclohydrolase (Hisi)

12.6. Phosphoribosyl-AMP Cyclohydrolase Inhibitors

12.7. 5'Profar Isomerase (HISA)

12.8. Imidazole Glycerol Phosphate Synthase (HISF/HISH)

12.9. Imidazole Glycerol Phosphate Synthase Inhibitors

12.10. Imidazole Glycerol Phosphate Dehydratase (Hisb)

12.11. Imidazole Glycerol Phosphate Dehydratase Inhibitors.

12.12. Histidinol Phosphate Aminotransferase (Hisc)

12.13. Histidinol Phosphate Aminotransferase Inhibitors

12.14. Histidinol Phosphate Phosphatase (HPP)

12.15. Histidinol Phosphate Phosphatase Inhibitors

12.16. Histidinol Dehydrogenase (HISD)

12.17. Histidinol Dehydrogenase Inhibitors

13. PROLINE BIOSYNTHESIS

13.1. Glutamate 5-Kinase (G5K)

13.2. Glutamate 5-Kinase Inhibitors

13.3. γ-Glutamyl Phosphate Reductase (GPR)

13.4. γ-Pyrroline-5-carboxylate reductase (P5CR)

14. Arginine Biosynthesis

14.1. Argininosuccinate Synthase (ASS1)

14.2. Argininosuccinate Synthase Inhibitors

14.3. Argininosuccinate Lyase (ASL)

14.4. Argininosuccinate Lyase Inhibitors

15. Lysine Biosynthesis

15.1. Dihydrodipicolinate Synthase (DHDPS)

15.2. Dihydrodipicolinate Synthase Inhibitors

15.3. Dihydrodipicolinate Reductase (DHDPR)

15.4. Dihydrodipicolinate Reductase Inhibitors

15.5. Tetrahydrodipicolinate N-Succinyltranferase (THDP)

15.6. Tetrahydrodipicolinate N-Succinyltranferase Inhibitors

15.7. Succinyl-Α-Amino-Ε-Ketopimelate-Glutamate Aminotransferase (DAP-AT).

15.8. Succinyl-Α-Amino-Ε-Ketopimelate-Glutamate Aminotransferase Inhibitors

15.9. N-Acyldiaminopimelate Deacylase (N-Acyldap)

15.10. N-Acyldiaminopimelate Deacylase Inhibitors

15.11. Diaminopimelate Epimerase (DAPE)

15.12. Diaminopimelate Epimerase Inhibitors

15.13. Diaminopimelate Decarboxylase (DAPDC)

15.14. Diaminopimelate Decarboxylase Inhibitors

15.15. Lysine Biosynthesis From Α-Aminoadipate.

16. ASPARTATE, ASPARAGINE AND GLUTAMATE BIOSYNTHESIS

16.1. Aspartate Aminotransferase (AT)

16.2. Aspartate Aminotransferase Inhibitors

16.3. Asparagine Synthetase (AS)

16.4. Asparagine Synthetase Inhibitors

17. GLUTAMINE AND GLUTATHIONE BIOSYNTHESIS

17.1. Glutamate Cysteine Ligase (GCL).

17.2. Glutamate Cysteine Ligase Inhibitors.

Notes:

Description based on print version record.

ISBN:

9789811460906

9811460906