Bioinspired organometallic analogues of iron-sites in metalloproteins / Steffen Meyer.

Format:

Book

Author/Creator:

Meyer, Steffen, author.

Language:

English

Subjects (All):

Bioinorganic chemistry.

Organometallic chemistry.

Physical Description:

1 online resource ( pages) : illustrations

Edition:

1st ed.

Place of Publication:

Gottingen, [Germany] : Cuvillier Verlag, 2015.

Summary:

Metalloproteins with iron-sites are essential for almost all living organisms and responsible for a large number of biological redox reactions. To uncover the mechanisms of enzymes and cofactors, bioinorganic chemistry aims to provide low-molecular weight analogues. In this dissertation, the iron-sites of [2Fe-2S] proteins, [NiFe] hydrogenases and mononuclear oxygenases served as models for bioinspired analogues coordinated by N-heterocyclic carbene (NHC) ligands. Although abiological, NHC ligands have been shown to be capable of stabilizing otherwise labile inorganic intermediates which are crucial for mechanistic understanding. Using this approach, the isolation of the first organometallic oxoiron(IV) complex, mimicking the oxygenase motif, was achieved. Studies on the structural and magnetic characteristics, substrate reactivity, and the decomposition pathway are provided.

Contents:

Intro

Table of Contents

1 General Introduction

2 Bioinspired [NiFe] Hydrogenase Models

3 Diferrous [2Fe-2S] Clusters

4 An Organometallic Oxoiron(IV) Complex

5 Experimental Part

6 Crystallography

Appendix.

Notes:

"Dissertation zur Erlangung des mathematisch-naturwissenschaftlichen Doktorgrades "Doctor rerum naturalium" der Georg-August-Universitat Gottingen."

Includes bibliographical references.

Description based on online resource; title from PDF title page (ebrary, viewed September 28, 2017).

ISBN:

9783736949201

3736949200