Bone cancer : bone sarcomas and bone metastases - from bench to bedside / edited by Dominique Heymann.

Format:

Book

Contributor:

Heymann, Dominique, editor.

Language:

English

Subjects (All):

Bones--Cancer.

Bones.

Bone metastasis.

Genre:

Electronic books.

Physical Description:

1 online resource : illustrations (black and white, and color)

Edition:

Third edition.

Place of Publication:

Amsterdam : Academic Press, 2021.

System Details:

text file

Contents:

Front Cover

Bone Cancer

Bone Cancer: Bone Sarcomas and Bone Metastases

From Bench to Bedside

Copyright

Contents

Contributors

Foreword I

Foreword II

Foreword III

Preface

I

Basic Aspects of Bone Cancers

Epidemiology of Bone Cancers

1

Cancer: lessons to learn from the past

Introduction

Who studies cancer(s) in ancient people(s)?

How do we recognize cancer in the past?

What do we know about the past of cancer? a global perspective

Documental evidence

Bioarchaeological evidence

Lessons from case-driven research

Lessons from population-driven research

Limits and pitfalls of paleo-oncology

Conclusion and perspectives

Acknowledgments

References

2

Epidemiology of primary bone tumors and economical aspects of bone metastases

Incidence of primary bone tumors

Age

Gender

Site distribution

Incidence of bone tumors as a secondary event

Racial differences in incidence of primary bone tumors

Incidence of bone metastases

Pathology of bone metastases

Cost of illness

Economic burden of bone metastasis

Conclusions

References

II

Animal Models of Bone Cancers

3

Mammalian models of bone sarcomas

Models based on the inoculation of cancer cells and the implantation of tumor fragments

Genetically engineered animal models

Conclusion

4

In vivo models used in studies of bone metastases

Models used in the studies of breast cancer bone metastases (Table 4.1)

Xenograft models

Intracardiac injection

Mechanisms of bone metastasis formation

Effects of therapies

Intravenous/intra-arterial injection

Mechanisms of bone metastasis formation

Intraosseous implantation

Syngeneic models

In vivo models of prostate cancer bone metastases (Table 4.2)

Intratibial implantation

Mechanisms of metastasis

Orthotopic implantation

Modeling metastasis to/in human bone (Table 4.3)

Murine models of myeloma-induced bone disease (Table 4.4)

Syngeneic murine models of MM

The 5T series of MM models

The 5T2 syngeneic model of MM

Tumor homing, colonization, and development

The effects of therapies

The 5T33 syngeneic model of MM (reduce)

The 5TGM1 syngeneic model of MM

Transgenic models of MM

Xenograft models of MM

SCID-xenograft models of MM

Tumor homing, colonization, and development

Notes:

Print version record.

Other Format:

Print version: Bone cancer.

OCLC:

1265405202

Access Restriction:

Restricted for use by site license.