Clostridioides Difficile : Infections, Risk Factors, Prevention and Treatment.

Format:

Book

Author/Creator:

Sommermeyer, Henning.

Contributor:

Piątek, Jacek.

Language:

English

Genre:

Electronic books.

Physical Description:

1 online resource (96 pages)

Place of Publication:

Cham : Springer International Publishing AG, 2021.

System Details:

text file

Contents:

Intro

Foreword

Preface

Acknowledgments

Contents

About the Authors

Abbreviations

List of Figures

List of Tables

1: Introduction

2: Microbiology

2.1 Taxonomy

2.2 Genome

2.3 Epigenome

2.4 Life Cycle of C. difficile During Infection

2.4.1 Spore

2.4.1.1 Spore Core

2.4.1.2 Inner Membrane

2.4.1.3 Germ Cell Wall

2.4.1.4 Cortex

2.4.1.5 Outer Membrane

2.4.1.6 Coat and Exosporium

2.4.2 Germination

2.4.2.1 Germinosome Model

2.4.2.2 Lock-and-Key Model

2.4.3 Sporulation

References

3: Pathophysiology of C. difficile

3.1 Toxins TcdA and TcdB

3.2 Genetics of TcdA and TcdB

3.3 Pathogenicity Locus

3.4 Toxinotypes of C. difficile Isolates

3.5 Environmental Signals Regulating Toxin Expression

3.6 Mechanism of Action and Functional Domains of TcdA and TcdB

3.7 Cell Surface Receptors for TcdA and TcdB

3.8 Receptor-Mediated Endocytosis and Membrane Translocation

3.9 Modification of Small GTPase Proteins as Host Cell Targets of TcdA and TcdB

3.10 Influence of TcdA and TcdB on Cell Physiology

3.11 Impact on Cell Morphology

3.12 Impact on Small GTPase Signaling Pathways

3.13 Role of TcdA and TcdB in Disease

3.14 Other Toxins Produced by C. difficile

3.15 Toxin Profiles of Clinical Isolates

References

4: Epidemiology

4.1 Historical Perspective

4.2 Hospital- and Community-Acquired CDI

4.3 Hypervirulent C. difficile Strain Ribotype 027 (NAP1/BI)

4.4 Other Strains of C. difficile

4.5 Dual Strain Infections

4.6 CDI in Children

4.7 Recurrent CDI

5: Risk Factors for CDI

5.1 Exposure to Healthcare Institutions

5.2 Antibiotics

5.3 Proton Pump Inhibitors

5.4 Advanced Age as Risk Factor for CDI

5.5 Cancer Therapy as Risk Factor for CDI

5.6 Other Risk Factors for CDI

5.7 Risk Factors for Community-Acquired CDI

5.8 Risk Factors for Recurrent CDI

5.9 CDI Risk Factors in Children

6: Diagnosis of CDI

7: Clinical Picture of CDI

7.1 From Asymptomatic Carriers to Life-Threatening Presentations

7.2 Pseudomembranous Colitis

8: Treatment of CDI

8.1 Antibiotics-Based Therapy

8.1.1 Antibiotics Used for Treatment of CDI

8.1.2 AB-Treatment of an Initial, Non-severe CDI Episode in Adults

8.1.3 AB-Treatment of a Fulminant Episode of CDI in Adults

8.1.4 AB-Treatment of a First or Multiple Recurrence of CDI in Adults

8.1.5 AB-Treatment of Non-severe Initial or First Recurrent CDI in Children

8.1.6 AB-Treatment of an Initial Episode of Severe CDI in Children

8.1.7 AB-Treatment of Second or Greater Episode of Recurrent CDI in Children

8.2 Fecal Microbiota Transplantation as Treatment for CDI

8.3 Probiotics and Synbiotics as Treatment for CDI

8.4 Surgical Treatment of Complicated CDI

Notes:

Description based upon print version of record.

References.

Other Format:

Print version: Sommermeyer, Henning Clostridioides Difficile

ISBN:

9783030811006

303081100X

OCLC:

1272995389

Access Restriction:

Restricted for use by site license.