Clinical bioenergetics : from pathophysiology to clinical translation / edited by Sergej M. Ostojic.

Format:

Book

Contributor:

Ostojic, Sergej M., editor.

Language:

English

Subjects (All):

Bioenergetics.

Genre:

Electronic books.

Physical Description:

1 online resource

Place of Publication:

London : Academic Press, [2020]

System Details:

text file

Contents:

Intro

Title page

Table of Contents

Copyright

Contributors

Preface

Acknowledgments

Part I. Foundational aspects of bioenergetics and disease

Chapter 1. Tissue specificity of energy metabolism in mitochondria

Introduction

Energetic metabolic profile of tissues and cell types

Mitochondrial heterogeneity and tissue-specific properties of mitochondria

Regulation of mitochondrial biogenesis and degradation

Conclusions and perspectives

Chapter 2. Impaired mitochondrial bioenergetics and signaling pathways: an overview

Introduction

Mitochondria-structure and functions

Electron transport chain

Mitochondrial bioenergetics

Signaling pathways

Impaired mitochondrial bioenergetics and signaling pathways

Conclusion and future perspectives

Part II. Disease-specific case studies

Chapter 3. Abnormal mitochondrial metabolism in obesity and insulin resistance

Abnormal mitochondrial metabolism in obesity and insulin resistance

Conclusion

Chapter 4. Impaired mitochondrial energy metabolism: etiologies and implications in neurodegenerative disease

Mitochondrial bioenergetics measurement parameters

Mechanisms of impaired mitochondrial metabolism

Intrinsic factors

Ca++ imbalance

Intracellular reactive oxygen species

Extrinsic factors

Impaired mitochondrial metabolism and neurodegenerative disease

Conclusions

Chapter 5. Mitochondrial dysfunction in kidney diseases

Key points

Conclusion and perspective

Conflict of interest

Chapter 6. Mitochondrial role in NAFLD as a chronic disease

Nonalcoholic fatty liver disease essentials

Nonalcoholic fatty liver disease lipid overload: mitochondrial status

Mitochondrial dysfunction

Mitochondrial dynamics

Mitochondrial DNA, role in nonalcoholic fatty liver disease

Conclusion remarks

Chapter 7. Decreased bioenergetics in traumatic brain injury

Classifications and diagnosis of traumatic brain injury

Oxidative stress and traumatic brain injury

Traumatic brain injury and dementia

Traumatic brain injury and its correlation to aggression

Traumatic brain injury and posttraumatic stress disorder

Concussive brain injuries

Reduced energy metabolism associated with mild and moderate traumatic brain injury

Glutamate excitotoxicity and traumatic brain injury

Calcium and traumatic brain injury

Reduced energetics associated with severe traumatic brain injury

Inner mitochondrial membrane

Peripheral dysfunction associated with traumatic brain injury

Treatment strategies for traumatic brain injury

Chapter 8. Impaired mitochondrial bioenergetics in psychiatric disorders

Notes:

Includes index.

Other Format:

Print version:

ISBN:

9780128227725

0128227729

OCLC:

1223028108

Access Restriction:

Restricted for use by site license.