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Sarcopenia : molecular mechanism and treatment strategies / edited by Kunihiro Sakuma.
- Format:
- Book
- Language:
- English
- Subjects (All):
- Musculoskeletal diseases in old age.
- Aging--Physiological aspects.
- Aging.
- Muscles--Diseases--Treatment.
- Muscles.
- Muscular dystrophy--Treatment.
- Muscular dystrophy.
- Muscles--Diseases.
- Genre:
- Electronic books.
- Physical Description:
- 1 online resource : illustrations (black and white, and colour)
- Place of Publication:
- Amsterdam : Elsevier, 2021.
- System Details:
- text file
- Summary:
- Sarcopenia: Molecular Mechanism and Treatment Strategies provides answers and guidance on a disease that has serious health consequences in terms of fractures, frailty, disability and diminished quality of life. Written by experts around the world, this book is for all those that care for aging populations. As the global population ages, sarcopenia remains a therapeutic challenge and major public health concern. Difficulties in defining sarcopenia as a clinical phenotype remain and have hindered treatment.
- Contents:
- Intro
- Sarcopenia: Molecular Mechanism and Treatment Strategies
- Copyright
- Contents
- Contributors
- Chapter 1 Linking mitochondrial dysfunction to sarcopenia
- Introduction
- Sarcopenia and mitochondrial function
- Potential sources of mitochondrial dysfunction in aging
- Reactive oxygen species-induced damage
- Mitochondrial DNA damage and aging
- Altered mitochondrial dynamics with aging
- Association of reduced activity and mitochondrial dysfunction in sarcopenia
- Calcium-induced dysregulation of mitochondria in sarcopenia
- Mitochondrial associated apoptosis, mitophagy, and UPS can be modulated by caloric restriction in sarcopenia
- Conclusions
- References
- Chapter 2 The role of the neuromuscular junction in sarcopenia
- Age-related structural adaptations of the NMJ
- Age-related functional adaptations of the NMJ
- Preventing and managing the effects of aging on the NMJ
- Role of NMJ in sarcopenia
- Chapter 3 Dietary approaches to maintaining muscle mass
- Dietary protein quality
- Defining high-quality protein sources
- Plant-based protein sources
- Animal-based protein sources
- Leucine as a determinant of protein quality
- Dietary protein quantity
- Protein intake above the RDA
- The importance of protein distribution across the day
- Dietary considerations for older adults
- Dietary protein intake consideration for older adults
- Impact of leucine on muscle mass maintenance in older adults
- Dietary approaches to preserving and gaining muscle mass in those with sarcopenia
- Dietary protein and amino acid interventions in older adults with sarcopenia
- Conclusions and future work
- References
- Other Format:
- Print version:
- ISBN:
- 9780128226575
- 0128226579
- 9780128221464
- 0128221461
- OCLC:
- 1262329012
- Access Restriction:
- Restricted for use by site license.
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