WHO recommendation on prophylactic antibiotics for women undergoing caesarean section / World Health Organization.

Format:

Book

Author/Creator:

World Health Organization, author.

Language:

English

Subjects (All):

Antibiotics.

Critical care medicine.

Obstetrics.

Physical Description:

1 online resource (ix, 50 pages)

Edition:

1st ed.

Place of Publication:

[Place of publication not identified] : World Health Organization, [2021]

Summary:

The Guideline Development Group noted that the available evidence on the effectiveness of antibiotics for caesarean section was largely derived from trials that tested first- or second-generation cephalosporins or penicillins in the 1980s and 1990s. Based on consensus, the Guideline Development Group favoured these classes of antibiotics over other classes of antibiotics, as they have a broad spectrum of activities and are widely available in all settings. While the Guideline Development Group members acknowledged the lack of clear difference between first- and second-generation cephalosporins, they noted that the evidence suggests that third-generation cephalosporins may be less effective than penicillins for this indication, and therefore suggests that this class of antibiotics should be avoided. The Guideline Development Group noted that first-generation cephalosporins are the preferred antibiotic class for prophylaxis in general surgery, as part of efforts to contain antimicrobial resistance. In acknowledgement of the lack of evidence on the comparative effectiveness of different classes of antibiotics, the Guideline Development Group concluded that when the recommended antibiotic classes are not available, other classes of antibiotics may also be used. The Guideline Development Group noted that the choice of an antibiotic class should be informed by local antimicrobial resistance guidance, local bacteriologic patterns of post-caesarean infectious morbidity, safety profile, the clinician's experience with that particular class of antibiotics, availability and cost.

Contents:

Intro

_GoBack.

Notes:

Description based on: online resource; title from PDF information screen (WHO, viewed October 22, 2022).