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Lahita's systemic lupus erythematosus / edited by Robert G. Lahita.
- Format:
- Book
- Language:
- English
- Subjects (All):
- Systemic lupus erythematosus.
- Genre:
- Electronic books.
- Physical Description:
- 1 online resource : illustrations (black and white, and colour)
- Edition:
- Sixth edition.
- Other Title:
- Systemic lupus erythematosus
- Place of Publication:
- Amsterdam : Academic Press, 2021.
- System Details:
- text file
- Contents:
- Front Cover
- LAHITA'S SYSTEMIC LUPUS ERYTHEMATOSUS
- Copyright
- Dedication
- Contents
- Contributors
- Foreword
- Foreword from the First Edition
- Preface to Edition 6, Systemic Lupus Erythematosus
- Acknowledgment
- History of lupus erythematosus
- References
- I
- Basis of the disease
- A Genetics and epigenetics
- 1
- Major histocompatibility complex and SLE
- The MHC region
- Overview
- Subregions of the MHC
- Evolution and gene clustering in the human MHC
- HLA polymorphism
- Extended linkage disequilibrium at the MHC
- Conserved extended haplotypes/ancestral haplotypes
- The sequence of the MHC
- Nomenclature of HLA and non-HLA alleles
- HLA class I molecules
- HLA class II molecules
- HLA-DRB gene haplotypes
- Genome-wide association studies and the MHC
- HLA typing by imputation
- MHC class III and the RCCX module
- The MHC region and SLE (HLA)
- The MHC region and SLE (complement)
- SNP-based MHC analyses in SLE
- Targeted SNP-based analysis
- GWAS and the MHC
- ImmunoChip and the MHC
- Combining SNPs with structural variation at the RCCX module
- Additional MHC associations with SLE
- The future...defining mechanisms
- 2
- Lupus susceptibility genes
- Introduction
- Identifying SLE susceptibility genes
- Pleotropic effects of SLE risk loci
- SLE risk loci impact pathways involved in key immune processes
- Autophagy, apoptosis, and exposure to self-antigens
- Interferon signaling
- The role of chromosome X in SLE
- Clinical translation of genetic findings
- Concluding remarks
- 3
- Epigenetics in systemic lupus erythematosus and the integration of molecular pathways
- What is epigenetics?
- DNA methylation in SLE
- Global loss of DNA methylation in lupus patients
- Hypomethylation in autoimmune-related genes: classical examples
- Defects in X-chromosome inactivation in SLE
- Increased retrotransposon genomic activity in SLE
- Global DNA methylation and CpG immunity
- Epigenome-wide association studies for SLE
- Methodological and statistical considerations of EWAS
- Choice of tissue
- Study design and interpretability of results
- Genome-wide DNA methylation association studies
- Pervasive hypomethylation of interferon-regulated genes
- Beyond the interferon signature
- Cell-specific DNA methylation signatures
- Activity-dependent DNA methylation signatures
- DNA methylation in relation to clinical phenotypes
- DNA hydroxymethylation landscape in SLE
- Histone modification landscapes in SLE
- MicroRNA changes in SLE
- Epigenetics as an intermediary of genetic and environmental risk
- Lupus stratification based on molecular profiles
- A bridge between clinical and molecular heterogeneity
- Molecular stratification "a new hope"
- Diagnostic and therapeutic implications of epigenetics
- Conclusions and future perspectives
- References
- ISBN:
- 9780323914888
- 0323914888
- OCLC:
- 1262330598
- Access Restriction:
- Restricted for use by site license.
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