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PARP-1in Parkinson's disease : from molecular and cellular mechanisms to therapeutic strategies / Laura Puentes.
Connect to full text Available online
View online- Format:
- Book
- Thesis/Dissertation
- Author/Creator:
- Puentes, Laura, author.
- Language:
- English
- Subjects (All):
- Pharmacology.
- Neurosciences.
- Pharmacology--Penn dissertations.
- Penn dissertations--Pharmacology.
- Local Subjects:
- Pharmacology.
- Neurosciences.
- Pharmacology--Penn dissertations.
- Penn dissertations--Pharmacology.
- Genre:
- Academic theses.
- Physical Description:
- 1 online resource (151 pages)
- Contained In:
- Dissertations Abstracts International 82-11B.
- Place of Publication:
- [Philadelphia, Pennsylvania] : University of Pennsylvania ; Ann Arbor : ProQuest Dissertations & Theses, 2021.
- Language Note:
- English
- System Details:
- Mode of access: World Wide Web.
- text file
- Summary:
- Poly (ADP-ribose)-polymerase 1 (PARP-1) is a DNA repair enzyme that has been implicated in regulating a number of inflammatory processes. Hyperactivation of PARP-1 has been linked to a number of inflammation-associated clinical conditions, including cancer, metabolic disorders, and neurodegenerative disease. Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by bradykinesia, tremors, and rigidity. PD is the second most common neurodegenerative disease after Alzheimer's disease, with an incidence rate that is estimated to increase by more than 30% in the next decade. Our understanding on the progression and mechanisms underlying the onset of PD have grown enormously in the past few decades. There is now growing evidence suggesting that PARP-1 hyperactivation is involved in driving PD and that poly (ADP-ribose) (PAR) - dependent cell death is responsible for neuronal loss. While inhibition of PARP-1 activity has proven beneficial in cancer therapy, there is a need to design and validate PARP-1 inhibitors (PARPi) with optimal physicochemical properties for complex neurological conditions. These pharmacological interventions may provide an alternative therapeutic approach for managing PD.
- Notes:
- Source: Dissertations Abstracts International, Volume: 82-11, Section: B.
- Includes supplementary digital materials.
- Advisors: Mach, Robert H.; Committee members: James Shorter; Roger Greenberg; Mark Sellmyer; Harry Ischiropoulos.
- Department: Pharmacology.
- Ph.D. University of Pennsylvania 2021.
- Local Notes:
- School code: 0175
- ISBN:
- 9798738641350
- Access Restriction:
- Restricted for use by site license.
- This item is not available from ProQuest Dissertations & Theses.
- This item must not be sold to any third party vendors.
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