Precision medicine in cardiovascular disease prevention / Seth S. Martin, editor.

Format:

Book

Contributor:

Martin, Seth S., editor.

Language:

English

Subjects (All):

Cardiovascular system--Diseases--Prevention.

Cardiovascular system.

Genre:

Electronic books.

Physical Description:

1 online resource

Place of Publication:

Cham : Springer, 2021.

System Details:

text file

Summary:

This book contains the current knowledge and potential future developments of precision medicine techniques including artificial intelligence, big data, mobile health, digital health and genetic medicine in the prevention of cardiovascular disease. It reviews the presently used advanced precision medicine techniques and fundamental principles that continue to act as guiding forces for many medical professionals in applying precision and preventative medical techniques in their day-to-day practices. Precision Medicine in Cardiovascular Disease Prevention describes current knowledge and potential future developments in this rapidly expanding field. It therefore provides a valuable resource for all practicing and trainee cardiologists looking to develop their knowledge and integrate precision medicine techniques into their practices.

Contents:

Intro

Preface

Acknowledgments

Contents

1 Social Determinants

Social Determinants of Health and Cardiovascular Care: A Historical Perspective

Landmark Reports on Health Disparities: Relevance to CVD

Role of SDOH in Cardiovascular Care: Ignored for Far Too Long

Current State of CVD Disparities in the US

SDOH, 'Traditional' Risk Factors and Current Models of CVD Care

SDOH and CVD: A Review of Current Literature

SDOH: A Domain-Based Analysis

Economic Stability

Current Evidence and Pathways

Summary

Education

Summary

Neighborhood and Physical Environment

Food

Community and Social Context

Healthcare

Conclusions

References

2 Biomarkers

Introduction

Lipid Biomarkers and Cardiovascular Risk

Low-Density Lipoprotein Cholesterol

Estimation of LDL-C in Precision Medicine

There is More Than LDL-C: LDL Particles and Apolipoprotein B

Non-High-Density Lipoprotein Cholesterol (non-HDL-C): The "Poor Man" apoB?

Maximizing the Use of the Standard Lipid Panel: The Total Cholesterol to HDL-C Ratio

Residual Risk and Lipoprotein-Related Risk Beyond LDL: Triglyceride-Rich Lipoproteins

Lipoprotein (a)-ready for Prime-Time Use?

Non-Lipid Cardiac Biomarkers in Risk Stratification of Asymptomatic Patients

Cardiac Biomarkers of Wall Stress and Myocardial Injury

Factors Affecting Biomarker Interpretation

Cardiac Troponin and Cardiovascular Risk

Cardiac Biomarkers in Hypertension

Cardiac Biomarkers in Aortic Stenosis

Cardiac Biomarkers in Heart Failure

HsCRP

GlycA

Galectin-3

Lp-PLA2

Hepatocyte Growth Factor

Fibrinogen

Adipokines

Sex Hormones

3 Genetics

Rare Variation Highlights Novel Disease Pathways

Background

Relevance for Cardiovascular Prevention

Leveraging Common Variant Genomics to Understand Disease Pathophysiology

Mendelian Randomization Can Help Us Understand Causal Relationships

Polygenic Risk Scores Can Improve Risk Prediction

Background

Relevance for Cardiovascular Prevention

Conclusions and Future Perspectives

4 Atherosclerosis Imaging

Traditional Risk Scores and Individualized Risk Assessment

Proposed Tools for Personalizing Risk Estimation

Serum Biomarkers and Genetics: Pros and Cons

Coronary Artery Calcium

CAC Imaging

CAC Scoring

Early Data

Major Population-Based Studies

MESA

Heinz Nixdorf

Rotterdam Study

Meta-Analysis

CAC in Guidelines

Shared Decision-Making

Risk Re-Classification Through CAC

CAC Future Directions

CAC Score = 0

Notes:

Includes index.

Online resource; title from PDF title page (SpringerLink, viewed July 28, 2021).

ISBN:

9783030750558

3030750558

OCLC:

1260133170

Access Restriction:

Restricted for use by site license.