Outcome measures and metrics in systemic lupus erythematosus / Zahi Touma, editor.

Format:

Book

Contributor:

Touma, Zahi, editor.

Language:

English

Subjects (All):

Systemic lupus erythematosus.

Systemic lupus erythematosus--Diagnosis.

Systemic lupus erythematosus--Treatment--Evaluation.

Evaluation.

Genre:

Electronic books.

Physical Description:

1 online resource

Place of Publication:

Cham, Switzerland : Springer, 2021.

System Details:

text file

Summary:

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that manifests with a myriad of clinical and laboratory features. The assessment of SLE is comprehensive and includes different core set domains; disease activity, damage, health-related quality of life, adverse events and economic impact. This comprehensive book is focused on the instruments and outcome measures utilized in the assessment of SLE. It targets different audiences including physicians, scientists/researchers and different health professionals interested in learning about the art of measurement in SLE. The book highlights the importance of measurement in the assessment of SLE in a clinical settings, research and clinical trials. Each of the chapters provide a systematic approach to the instruments utilized in the assessment of a specific construct in SLE (e.g., disease activity, fatigue, etc.) and incorporate a comprehensive coverage of disease specific and disease generic measures. It also discusses different patient-reported outcomes that are crucial to reflect patient perceptions of their health condition and cover constructs such as fatigue, pain, anxiety and depression, cognition, frailty, and many others.

Contents:

Intro

Preface

Acknowledgment

Contents

Contributors

Chapter 1: Introduction: Metrics and Domains Measured in SLE

Introduction

Core Set of Domains in SLE, Classification, and Response Criteria

Core Domain 1: Disease Activity

Core Domain 2: Chronic Damage Resulting from Lupus Activity or Its Treatment

Disease Activity and Damage in Special Circumstances: Childhood and Pregnancy

Childhood

Pregnancy

Core Domain 3: Health-Related Quality of Life

Core Domains 4: Adverse Events of Drugs

Core Domain 5: Economic Impact

Emerging Concepts in SLE and Deep Insights on Selected Concepts

Cognitive Impairment

Depression and Anxiety

Fatigue and Pain

Frailty

Instrument Selection: The OMERACT Process

Facilitating Development of Response Criteria and Classification Criteria: EULAR/ACR Collaborative Projects

Conclusion

Bibliography

Chapter 2: Clinical Aspects of Systemic Lupus Erythematosus

Classification of SLE

General Manifestations

Cutaneous Manifestations

Acute Cutaneous Lupus

Chronic Cutaneous Lupus

Non-specific Cutaneous Lesions

Musculoskeletal Features

Lupus Myositis

Other Musculoskeletal Manifestations

Renal Manifestations

Neuropsychiatric Manifestations

Gastrointestinal Involvement

Mucocutaneous Lesions

Lupus Enteritis

Serositis

Associated Hepatobiliary Manifestations

Hematologic Manifestations

Pulmonary Involvement

Cardiac Manifestations

Accelerated Atherosclerosis

References

Chapter 3: Diagnosis and Classification of Systemic Lupus Erythematosus

Classification Criteria Are Not Diagnostic Criteria

2019 EULAR/ACR Classification Criteria

Item Generation and New Insights About What Constitutes SLE

Phase 2. Reducing the Number of Criteria and Other Lessons Learned

Phase 3. Weighting and Threshold Identification

Phase 4. Validation

Summary

Chapter 4: Challenges and Advances in SLE Autoantibody Detection and Interpretation

Important Considerations in Interpretation of ANA Test Results and Reports

Specific Autoantibodies

Chromatin Components

Double-Stranded DNA

Histones

Nucleosomes

High-Mobility Group Proteins

Dense Fine Speckled (DFS)

Notes:

Includes index.

Online resource; title from PDF title page (SpringerLink, viewed August 4, 2021).

ISBN:

9783030733032

3030733033

OCLC:

1261380662

Access Restriction:

Restricted for use by site license.