Bovine Spongiform Encephalopathy : The BSE Dilemma / edited by Clarence F. Gibbs, Jr.

Format:

Book

Contributor:

Gibbs, Clarence J., 1924- editor.

United States. Animal and Plant Health Inspection Service, issuing body.

Series:

Serono Symposia USA

Language:

English

Subjects (All):

Internal medicine.

Virology.

Family medicine.

Internal Medicine.

General Practice and Family Medicine.

Local Subjects:

Internal Medicine.

Virology.

General Practice and Family Medicine.

Physical Description:

1 online resource (XXV, 413 p.)

Edition:

1st ed. 1996.

Place of Publication:

New York, NY : Springer New York : Imprint: Springer, 1996.

Language Note:

English

Summary:

The very first international working discussion on slow infections of the nervous system was entitled "Slow, Latent, and Temperate Virus Infec­ tions" and was held at the National Institutes of Health (NIH) in December 1964. The primary impetus was the discovery and investigation of kuru in New Guinea by D. Carleton Gajdusek, M. D. This working discussion brought together investigators in human and veterinary medicine, virolo­ gists, microbiologists, and neuropathologists actively engaged in laboratory work with viruses that illustrated properties of latency, masking, slowness, or temperateness, with emphasis on subacute and chronic neurologic dis­ eases of unknown etiology. In the Preface to the monograph of published papers presented at the working discussion, Gajdusek and Gibbs wrote the following: After microbiology had given solution to the etiology of most acute infections of the central nervous system and after fungi and bacteria had been incriminated in impor­ tant chronic disorders of the nervous system such as torula and tuberculosis men­ ingitis, we have been left, in neurology, with a wide range of subacute and chronic affections of the central nervous systems of unknown etiology. Some of these diseases, still listed as idiopathic, are among the most prevalent afflictions of the central nervous system. Many others with familial patterns of occurrence do not yet have their basic pathogenesis or underlying metabolic defect elucidated, although we tend to think of them as genetically mediated.

Contents:

1. The Potential Risk to Humans of Amyloids in Animals

I. Host Range and Pathogenesis

2. Bovine Spongiform Encephalopathy Distribution and Update on Some Transmission and Decontamination Studies

3. Preliminary Observations on the Pathogenesis of Experimental Bovine Spongiform Encephalopathy

4. Recent Observations on the Epidemiology of Bovine Spongiform Encephalopathy

II. Transmission and Pathogenesis of Spongiform Encephalopathies

5. Scrapie: Studies on Vertical and Horizontal Transmission

6. Transmission of Sheep and Goat Strains of Scrapie from Experimentally Infected Cattle to Hamsters and Mice

7. Experimental Transmission of Scrapie to Cattle

8. An Assessment of Transmissible Mink Encephalopathy as an Indicator of Bovine Scrapie in U.S. Cattle

9. Experimental Infections of Cattle and Mink with the Agents of Transmissible Mink Encephalopathy, Scrapie, and Bovine Spongiform Encephalopathy

10. BSE-Free Status: What Does It Mean?

11. Differing Neurohistologic Images of Scrapie, Transmissible Mink Encephalopathy, and Chronic Wasting Disease of Mule Deer and Elk

12. Analysis of Risk Factors and Active Surveillance for BSE in Argentina

13. Speculations on the Origin of BSE and the Epidemiology of CJD

III. Biochemistry: Protein Chemistry, Molecular Biology, and Molecular Genetics of the Spongiform Encephalopathies

14. Structure and Biologic Characteristics of Prion Protein (Scrapie Amyloid): Implications for the Safety of Naturally Derived Biologics

15. Prion Strains and Neuromuscular Disease in PrP Transgenic Mice

16. Deciphering Prion Diseases with Transgenic Mice

17. Posttranslational Modifications and Conformational Changes of PrPSc and Their Relationship to Infectivity

18. Amyloidosis: The Key to the Epidemiology and Pathogenesis of Transmissible Spongiform Encephalopathies

19. Effect of Amphotericin B on Different Experimental Strains of Spongiform Encephalopathy Agents

IV. Pathogenesis, Molecular Biology and Genetics, and Immunohistochemistry

20. Genetics of Human Spongiform Encephalopathies: Current Status

21. PrP Allelic Variants Associated with Natural Scrapie

22. The Formation of Scrapie-Associated Prion Protein In Vitro

23. Proteinase K-Resistant Prion Protein Detection in Animal Tissues and In Vitro

24. Elimination of Scrapie-Agent Infectivity in Naturally Derived Biologics

25. Cellular and Scrapie Prion Protein Immunolocalization and In Vitro Amyloid Formation

V. Public Health Considerations of Human and Animal Spongiform Encephalopathies

26. Real and Theoretical Threats to Human Health Posed by the Epidemic of Bovine Spongiform Encephalopathy

27. Incidence of Creutzfeldt-Jakob Disease in the European Community

28. Problems in the Evaluation of Theoretical Risks for Humans to Become Infected with BSE-Contaminated Bovine-Derived Pharmaceutical Products

29. Evaluation of BSE Risk Factors Among European Countries

Author Index.

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references at the end of each chapters and indexes.

ISBN:

9781461224068

1461224063

OCLC:

1076272918