Chemo-enzymatic cascade reactions / Dunming Zhu.

Format:

Book

Author/Creator:

Zhu, Dunming, author.

Language:

English

Subjects (All):

Biocatalysis.

Physical Description:

1 online resource.

Place of Publication:

Weinheim, Germany : Wiley-VCH GmbH, [2021]

Summary:

Chemo-Enzymatic Cascade Reactions A groundbreaking book focusing on chemo-enzymatic cascade transformations Chemo-Enzymatic Cascade Reactions offers a unique book that explores biocatalytic-chemical cascade reactions and their applications in the synthesis of valuable chemicals. Written by a noted expert on the topic, this comprehensive resource includes information on the advantages and disadvantages of traditional chemical and biocatalytic reactions and reviews the three modes of chemo-enzymatic transformations: separate-pot-two-step, one-pot-two-step, and one-pot-one-step. The author examines the most current developments of chemo-enzymatic transformations organized by the three modes and types of enzymes and considers retro-synthesis based on both chemical and biocatalytic transformations and the synthetic applications. This groundbreaking book is the first resource to present in one volume the state-of-art advances of the technology and explore the opportunities and challenges of this burgeoning field. The book also considers the future of cascade reactions and the myriad benefits including higher atom economy and production efficiency, and less resource consumption and waste generation. This important book: * Offers the first book dedicated exclusively to chemo-enzymatic cascade transformations * Explains the importance and the opportunities and challenges of chemo-enzymatic synthetic technology * Includes information on the three modes of chemo-enzymatic transformation * Reviews the most recent advances in the field Written for organic chemists, chemists in industry, biochemist, catalytic chemists, Chemo-Enzymatic Cascade Reactions offers an understanding to the importance, current advances, the opportunities and challenges of chemo-enzymatic synthetic technology.

Contents:

Cover

Title Page

Copyright

Contents

Preface

Chapter 1 Introduction

1.1 Advantages of Enzyme Catalysis

1.1.1 Chemoselectivity

1.1.2 Regioselectivity

1.1.3 Stereoselectivity

1.1.4 Mild Reaction Conditions

1.2 Modes of Chemoenzymatic Transformations

1.2.1 "Separate-Pot Two-Step" Mode

1.2.2 "One-Pot Two-Step" Mode

1.2.3 "One-Pot One-Step" Mode

References

Chapter 2 "Separate-pot Two-step" Chemoenzymatic Transformation

2.1 Lipases

2.2 Nitrilases

2.3 Carbonyl Reductases

2.4 Ene Reductases

2.5 Transaminases

2.6 Imine Reductases

2.7 Cytochromes P450s

2.8 Baeyer-Villiger Monooxygenases (BVMOs)

2.9 Aldolases

2.10 Epoxide Hydrolases

2.11 Other Enzymes

2.12 Integration of Multienzyme Cascade with Chemical Transformation

2.13 Summary and Outlook

Chapter 3 One-pot Sequential Chemoenzymatic Reactions

3.1 Lipases and Esterases

3.2 Carbonyl Reductases

3.3 Ene Reductases

3.4 Transaminases

3.5 Epoxide Hydrolases (EHs)

3.6 Other Enzymes

3.6.1 Aldolases

3.6.2 Halohydrin Dehalogenases

3.6.3 Phenylalanine Ammonia Lyases

3.6.4 d-Amino Acid Dehydrogenases (DAADHs)

3.6.5 Halogenases

3.6.6 Imine Reductases

3.6.7 Decarboxylases

3.6.8 Cytochrome P450s

3.6.9 Hydroxynitrile Lyases

3.6.10 Nitrilases

3.6.11 Laccases

3.6.12 Transglutaminases

3.6.13 α-Ketoglutarate (α-KG)-dependent Non-heme Iron Oxygenases

3.6.14 Galactose Oxidases

3.6.15 FAD-dependent Monooxygenases

3.7 Summary and Outlook

Chapter 4 Chemoenzymatic Dynamic Kinetic Resolution

4.1 Enzymatic Kinetic Resolution

4.2 Dynamic Kinetic Resolution

4.3 Racemization Techniques

4.4 DKR of Chiral Alcohols

4.5 DKR of Chiral Amines

4.6 DKRs of Other Compounds

4.7 Summary and Outlook

References.

Chapter 5 Chemoenzymatic Concurrent Deracemization

5.1 Deracemization of Amino Acids and Amines

5.2 Deracemization of Hydroxy Acids and Alcohols

5.3 Deracemization of Chiral Sulfoxides

5.4 Summary and Outlook

Chapter 6 One-pot Concurrent Chemoenzymatic Reactions

6.1 One-pot Concurrent Chemoenzymatic Cascades

6.1.1 Lipases

6.1.2 Carbonyl Reductases

6.1.3 Enoate Reductases

6.1.4 Transaminases

6.1.5 Monoamine Oxidases

6.1.6 Cytochrome P450s

6.1.7 Halohydrin Dehalogenases

6.1.8 Vanadium Haloperoxidases

6.1.9 Laccases

6.2 Integration of Chemical Reaction with Metabolism of Living Organisms

6.3 One-pot Concurrent Chemoenzymatic Cascades via Compartmentalization

6.4 Summary and Outlook

Chapter 7 Photocatalytic and Biocatalytic Cascade Transformations

7.1 Photoenzymes

7.2 Light-Activation of Redox Enzymes Without Cofactor Regeneration

7.3 Light-Activated Cofactor Regeneration for Redox Enzymes

7.4 Photoinduced Catalytic Promiscuity of Redox Enzymes

7.5 Photocatalysis and Biocatalysis Cascades

7.6 Summary and Outlook

Chapter 8 Perspectives

Index

EULA.

Notes:

Description based on print version record.

Includes bibliographical references and index.

ISBN:

9783527814282

3527814280

9781523136681

1523136685

9783527814275

3527814272

OCLC:

1243548891