Recent trends in nanomedicine and tissue engineering. / Jince Thomas [and three others], editors.

Format:

Book

Contributor:

Thomas, Jince, editor.

Series:

River Publishers series in research and business chronicles: biotechnology and medicine.

River Publishers series in research and business chronicles: biotechnology and medicine

Language:

English

Subjects (All):

Nanomedicine.

Tissue engineering.

Physical Description:

1 online resource (432 pages) : illustrations, tables.

Edition:

1st ed.

Place of Publication:

Denmark : River Publishers, [2017]

Summary:

Recent trends in Nanomedicine and Tissue Engineering covers numerous recent technological and research accomplishments in the area of Nanomedicine and Tissue Engineering. The book follows recent trends in drug delivery systems, wound healing fields, cancer therapies, protection of teeth and also other health care systems.

Contents:

Cover

Half Title

Series

Title

Copyright

Contents

Preface

Acknowledgement

List of Contributors

List of Figures

List of Tables

List of Abbreviations

1 Nanomedicine and Nanotechnology: State of Art, New Challenges and Opportunities

1.1 Introduction

1.2 Scope

1.2.1 Drug Delivery

1.2.2 Tissue Engineering and Nanoscaffolding and Wound Healing

1.2.3 Diagnostics

1.3 History

1.4 Commercial Significance and Current Challenges

References

2 Novel Approaches to Nanomedicine and Nanotechnology

2.1 Introduction

2.2 Nanomedicine

2.3 History of Nanomedicine

2.3.1 Present Facing Challenges

Translation of Nanotechnology to Nanomedicine

2.4 Nanoparticles in Cancer Therapy

2.4.1 Liposomes

2.4.2 The Solid Lipid Nanoparticles

2.4.3 Carbon Nanotubes

2.4.4 Carbon Nanotubes in Cancer Treatment

2.4.4.1 Single-walled carbon nanotubes in the treatment of cancer

2.4.4.2 Multi-walled carbon nanotubes in the treatment of cancer

2.4.5 Drug Delivery

2.4.6 The Applications of Nanoparticles in Drug Delivery

2.5 Nanoparticles Anti-Oxidative Role in Diabetes

2.5.1 Nanomedicine in Management of Diabetes

2.6 Nanorobotics

2.6.1 Types of Nanorobots

2.6.1.1 In surgery

2.6.1.2 Drug delivery

2.6.1.3 In diagnosis

2.6.2 Applications of Nanorobots in Medicine

2.6.3 Advantages of Nanorobots

2.6.4 Disadvantages of Nanorobots

2.7 Future Development of Nanomedicine

2.8 Conclusion

Acknowledgment

3 Chitosan and Its Derivatives as a Potential Nanobiomaterial: Drug Delivery and Biomedical Application

3.1 History

3.2 Chemistry

3.3 Advantages

3.4 Disadvantages

3.5 Properties of Chitosan

3.5.1 Physicochemical

3.5.1.1 Crystalline structure

3.5.1.2 Degree of N-Acetylation

3.5.1.3 Molecular weight

3.5.1.4 Solubility.

3.5.1.5 Viscosity

3.5.2 Biological Properties

3.5.2.1 Mucoadhesive properties

3.5.2.2 Permeation enhancing properties

3.5.2.3 Haemostatic activity

3.5.2.4 Antimicrobial activity

3.5.2.5 Analgesic effect

3.5.2.6 Biodegradability

3.6 Extraction of Chitosan

3.6.1 Preparation of Chitosan and Water Soluble Chitosan

3.6.1.1 Extraction of Chitin from the Beetle

3.6.1.2 Extraction of collagen from squid

3.6.1.3 Extraction of chitosan from fungi cell wall

3.6.1.4 Extraction of Chitin, Chitosan, from Shrimp by biological method

3.7 Chitosan Derivatives

3.7.1 Carboxymethylchitosan

3.7.2 Mono-Carboxymethylated Chitosan

3.7.3 N-Succinyl Chitosan

3.7.4 N-Acetylated Chitosan

3.7.5 N-Trimethyl Chitosan

3.7.6 N-Trimethylchitosan Chloride

3.7.7 Succinate and Chitosan Phthalate

3.7.8 Amphiphilic Chitosan Derivatives

3.7.9 Graft-Copolymerization of Chitosan

3.7.10 Thiolated Chitosan Conjugate

3.7.11 Cyclodextrin (CD)-Chitosan Derivative

3.8 Applications of Chitosan as Nanobiomaterial

3.8.1 Mucoadhesive Property

3.8.2 Permeation Enhancement

3.8.3 Wound Healing

3.8.4 Gene Delivery

3.8.5 Vaccine Delivery

3.9 Conclusion

4 Design and Characterization of Lipid Mediated Nanoparticles Containing an Anti-Psychotic Drug for Enhanced Bio-Availability

4.1 Introduction

4.2 Experimental Part

4.2.1 Preformulation Studies

4.2.1.1 Solubility studies

4.2.1.2 Compatibility study

4.2.1.3 Development of calibration curve

4.2.1.4 Partition coefficient studies

4.2.2 Preparation of Solid Lipid Nanoparticles (SLN) by Microemulsion Technique

4.2.2.1 Optimization of lipid quantity

4.2.2.2 Study on the effect of formulation process variables

4.2.2.3 Preparation of drug loaded batches

4.2.3 Evaluation of Solid Lipid Nanoparticles.

4.2.3.1 Particle size, zeta potential and polydispersity index

4.2.3.2 Entrapment efficiency and drug loading

4.2.3.3 Differential scanning calorimetry

4.2.4 In vitro Release Studies

4.2.5 In vivo Oral Bioavailability Studies

4.2.6 Bioanalytical Method Development and Analysis

4.2.6.1 Chromatographic conditions

4.2.6.2 Preparation of olanzapine standard stock solution

4.2.6.2.1 Standard stock solution of IS (Internal standard)

4.2.6.3 Preparation of analytical calibration curve solutions

4.2.6.4 Preparation of blank plasma

4.2.6.5 Preparation of bio-analytical calibration curve samples

4.2.6.6 Preparation of plasma samples

4.2.6.7 Method of analysis

4.3 Results and Discussion

4.3.1 Preformulation Studies

4.3.1.1 Solubility studies

4.3.1.2 Compatibility Studies

4.3.1.3 Development of calibration curve

4.3.1.4 Partition coefficient studies

4.3.2 Effect of Formulation Process Variables

4.3.3 Evaluation of Solid Lipid Nanoparticles

4.3.3.1 Zeta potential

4.3.3.2 Polydispersity

4.3.3.3 Entrapment efficiency and drug loading

4.3.3.4 Differential scanning colorimetry

4.3.3.5 In vitro release studies

4.3.3.6 Release kinetics

4.3.4 Bioanalytical Method Development and Analysis

4.4 Conclusion

5 Nanogels: The Emerging Carrier in Drug Delivery System

5.1 Introduction

5.2 Properties of Nanogels

5.2.1 Good Drug Loading Capacity

5.2.2 Solubility

5.2.3 Colloidal Stability

5.2.4 Particle Size

5.2.5 Biocompatibility and Degradability

5.2.6 Electro Mobility

5.2.7 Non-Immunologic Response

5.2.8 Others

5.3 Classification of Nanogels

5.3.1 Responsive Type

5.3.1.1 Non-responsive nanogels

5.3.1.2 Stimuli-responsive nanogels

5.3.2 Linkage Type

5.3.2.1 Physical cross-linked gels

5.3.2.2 Liposomes modified nanogels.

5.3.2.3 Micellar nanogels

5.3.2.4 Hybrid nanogel

5.3.2.5 Chemically cross-linked nanogels

5.4 Method of Preparation of Nanogel

5.4.1 Photolithographic Technique

5.4.2 Micro-Moulding Method

5.4.3 Bi-Polymers Synthesis Technique

5.4.4 Water in Oil (W/O) Heterogeneous Emulsion Method

5.4.5 Inverse Mini Emulsion Method

5.4.6 Reverse Micellar Method

5.4.7 Membrane Emulsification Method

5.4.8 Heterogeneous Free Radical Polymerization

5.4.8.1 Inverse micro emulsion

5.4.8.2 Inverse mini-emulsion polymerization

5.4.8.3 Precipitation polymerization

5.4.8.4 Dispersion polymerization

5.4.8.5 Heterogeneous controlled/living radical polymerization

5.4.9 Conversion of Macrogels to Nanogels

5.4.10 Chemical Cross-Linking Method

5.5 Characterization of Nanogel

5.5.1 Morphological Analysis

5.5.1.1 Scanning Electron Microscopy (SEM)

5.5.1.2 Transmission Electron Microscopy (TEM)

5.5.2 Size and Shape

5.5.3 Viscosity

5.5.4 Phase Behaviour

5.5.5 Optical Transparency

5.5.6 Spectroscopic Analysis

5.5.7 pH

5.6 Routes of Administration of Nanogel

5.6.1 Parenteral Drug Delivery System

5.6.2 Oral Drug Delivery System

5.6.3 Transdermal Drug Delivery

5.6.4 Ocular Drug Delivery System

5.6.5 Pulmonary or Intranasal Drug Delivery System

5.7 Application of Nanogels

5.7.1 Nano-Sized Drug Delivery System

5.7.2 Peptide and Protein Delivery

5.7.3 Vaccine Delivery

5.7.4 Gene Delivery

5.7.5 Antiviral Nanogel Delivery

5.7.6 Antifungal Nanogel Delivery

5.7.7 In Autoimmune Diseases

5.7.8 Ophthalmic Delivery

5.7.9 Diabetes

5.7.10 Coagulating Agent

5.7.11 Anti-Inflammatory Agent

5.8 Disadvantages of Nanogel

5.9 Conclusion

6 Fe, Co Based Bio-Magnetic Nanoparticles (BMNPs): Synthesis, Characterization, and Biomedical Application.

6.1 Introduction

6.1.1 Magnetic Properties

6.1.2 Magnetic Nanoparticles

6.1.2.1 Iron and iron oxide nanoparticles

6.1.2.2 Cobalt-based nanoparticles

6.2 Synthesis and Characterization of Magnetic Nanoparticles (MNPs)

6.2.1 Iron Oxide (Fe3O4) Nanoparticles (ION)

6.2.2 Cobalt-Based (FeCo) Nanoparticles (CBN)

6.3 Synthesis and Characterization of Core/Shell Magnetic Nanoparticles (CS-MNPs)

6.3.1 Iron Oxide Core/Shell Nanoparticles (IOCSN)

6.3.1.1 Fe3O4@Ag core/shell nanoparticles

6.3.1.2 Fe3O4@Chitosan core/shell nanoparticles

6.3.2 Cobalt-Based Core/Shell Nanoparticles (CBCSN)

6.3.2.1 FeCo@C core/shell nanoparticles

6.3.2.2 FeCo@PEG core/shell nanoparticles

6.4 Biomedical Application of Magnetic Nanoparticles (MNPs)

6.4.1 Bioimaging Application of MNPs

6.4.2 Controlled Drug Delivery (TDD) Applications of MNPs

6.4.3 Cancer Diagnosis and Treatment via Hyperthermia Method (CDT) Using MNPs

6.5 Conclusion

7 Comparative Study on Cytotoxic and Bactericidal Effect of Nanoscale Zero Valent Iron Synthesized through Chemical and Biological Methods

7.1 Introduction

7.2 Materials and Methods

7.2.1 Materials

7.2.2 Methods

7.2.2.1 Synthesis of nanoscale Zero Valent Iron (nZVI) by chemical and biological methods

7.2.3 Characterization Studies

7.2.4 Screening of Bactericidal and Cytotoxic Activity

7.3 Results and Discussion

7.3.1 Synthesis of Nanoscale Zero Valent Iron (nZVI) by Chemical and Biological Methods

7.3.2 Characterization of nZVI Particles

7.3.3 Screening of Bactericidal and Cytotoxic Activity

7.4 Conclusion

8 Simulation Studies of Nanomotors Based on Carbon Nanotubes for Nanodelivery Systems

8.1 Introduction

8.2 Nanomotor

8.3 Protein Structure

8.4 Simulation Method

8.5 Summary and Future Scope.

References.

Notes:

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-000-79615-9

1-00-333923-9

1-003-33923-9

1-000-79338-9

87-93609-15-9

9781003339236

OCLC:

1260321722

Publisher Number:

9788793609167