Hematologic malignancies : case studies in cytogenetic and molecular genetics / Manorama Bhargava.

Format:

Book

Author/Creator:

Bhargava, Manorama, author.

Language:

English

Subjects (All):

Leukemia--Genetic aspects--Case studies.

Leukemia.

Bone marrow--Diseases--Genetic aspects--Case studies.

Bone marrow.

Blood--Diseases--Genetic aspects--Case studies.

Blood.

Leukemia--Genetic aspects.

Blood--Diseases.

Bone marrow--Diseases.

Genre:

Electronic books.

Case studies.

Physical Description:

1 online resource (261 pages)

Place of Publication:

Singapore : Springer, [2021]

System Details:

text file PDF

Summary:

This book is a compendium of case studies in hematologic malignancies such as acute leukemias, myelodysplastic and myeloproliferative neoplasms, chronic leukemias and multiple myeloma covering cytogenetics (karyotyping Fluorescence in sitn hybridization (FISH)) and molecular studies in detail. The first few chapters describe the methodology employed for karyotyping, FISH and Real Time PCR technology conducive to establishment of these labs if required. Each case study is described in detail by including the clinical history of the patient, findings of peripheral blood, bone marrow aspirate and bone biopsy morphological details. This is then followed by flowcytometric immunophenotyping, cytogenetic and molecular observations leading collectively to a final diagnosis, A discussion follows based on the relevance of this data in informing the prognosis, treatment response and survival in these patients. Additionally, this data serves as a key determinant for clinical decision making involving evidence based rational management of patients including targeted therapy. For better understanding, each case study is accompanied by black and white or colour images as appropriate. This book is a source of learning and a valuable read for clinical hematologists, hematopathologists, medical oncologists, residents, interns, DM Hematology students and DNB Hematology students as well.

Contents:

Techniques in Cytogenetics

Techniques in Molecular Haematology

Part: I - Case Studies in Myeloid Malignancies

Acute Myeloid Leukemia

Myelodysplastic Syndrome

Myelodysplastic Syndromes - Myeloproliferative Neoplasms

Myeloproliferative Neoplasms

Chronic Myeloid Leukemia

Next Generation Sequencing for Diagnostics of Myeloid Malignancies for Routine Clinical Use: Pitfalls and Advantages

Part: II - Case Studies in Lymphoid Malignancies

Acute Lymphoblastic Leukemia

Chronic Lymphocytic Leukemia and Non Hodgkins Lymphoma

Part: III - Case Studies in Multiple Myeloma

Multiple Myeloma.

Notes:

Includes bibliographical references.

Description based upon print version of record.

Other Format:

Print version: Bhargava, Manorama Hematologic Malignancies

ISBN:

9789813347991

9813347996

OCLC:

1237869027

Access Restriction:

Restricted for use by site license.