Nutritional management and metabolic aspects of Hyperhomocysteinemia Mostafa I. Waly, editor

Format:

Book

Author/Creator:

WALY, MOSTAFA.

Contributor:

Waly, Mostafa I., editor.

Language:

English

Subjects (All):

Blood--Diseases--Diet therapy.

Blood.

Blood--Diseases--Nutritional aspects.

Homocysteine.

Hyperhomocysteinemia--physiopathology.

Hyperhomocysteinemia--complications.

Homocysteine--metabolism.

Medical Subjects:

Hyperhomocysteinemia--physiopathology.

Homocysteine.

Hyperhomocysteinemia--complications.

Homocysteine--metabolism.

Physical Description:

1 online resource

Place of Publication:

Cham Springer 2021

System Details:

text file

Summary:

Elevated blood concentrations of homocysteine, B vitamins deficiencies and oxidative stress are etiological factors for many human chronic diseases, yet the etiologic relationship of hyperhomocysteinemia to these disorders remains poorly understood. Clinical trials continue to support the notion that hyperhomocysteinemia is involved in the pathogenesis of oxidative stress and its associated impairment of cellular redox status. Antioxidants, phytochemicals, and bioactive agents are thought to be associated with the reduction of oxidative stress and reducing risk of chronic diseases, yet their role in preventing hyperhomocysteinemia-mediated oxidative stress has not been well covered in the literature. Nutritional Management and Metabolic Aspects and of Hyperhomocysteinemia comprehensively covers the nutritional-based intervention for combating hyperhomocysteinemia-mediated oxidative stress, metabolic regulation of homocysteine-dependent transulfuration and transmethylation pathways, and the identification of novel biomarkers for early diagnosis of hyperhomocysteinemia. The main goal of this text is to address the biochemical and nutritional aspects of hyperhomocysteinemia in relation to increasing risk of chronic diseases, providing insight into the etiology of hyperhomocysteinemia and covering new research on the effective reduction and management of hyperhomocysteinemia-associated chronic diseases. For researchers seeking a singular source for the understanding of the biochemical aspects and nutrition-based combat of hyperhomocysteinemia, its risk factors, preventive measures, and possible treatments currently available, this text provides all of the important needed information in up-to-date and comprehensive form

Contents:

Intro

Preface

Contents

Contributors

About the Editor

Chapter 1: Signaling Pathways of Hyperhomocystenemia and Oxidative Stress

1 Introduction

2 Cofactors for Re-Methylation and Trans-Sulfuration Pathways

2.1 Folate

2.2 Vitamin B12

2.3 Vitamin B6

3 Hyperhomocysteinemia and Oxidative Stress

4 Conclusion

References

Chapter 2: Hyperhomocysteinemia and Cancer: The Role of Natural Products and Nutritional Interventions

2 Biosynthesis of Homocysteine

3 Metabolism of Homocysteine

3.1 Remethylation

3.2 Transsulfuration

4 Hyperhomocysteinemia Induction

4.1 Genetic Enzymatic Defects

4.2 Absence/Inadequate Amounts of Certain Cofactors

4.3 Excessive Methionine Consumption

5 Diseases Associated with Hyperhomocysteinemia

5.1 Chronic Renal Failure

5.2 Hypothyroidism

5.3 Anemia

5.4 Malignant Tumors

5.5 Medications

6 Hyperhomocysteinemia and Cancer

7 Hyperhomocysteinemia Management Using Natural Products and Diet

8 Conclusion

Chapter 3: Anti-inflammatory Role of Anthocyanins in the Prevention of Hyperhomocysteinemia-Mediated Cardiometabolic Diseases

1 Introduction

2 Inflammation

3 Inflammation and Hyperhomocysteinemia

4 Cardiometabolic Diseases and Plant Polyphenols

5 Homocysteine and Anthocyanins

6 Anthocyanins: The Treasure of Health

6.1 Chemical Structure and Chemistry of Anthocyanins

6.2 Anthocyanin and Inflammation

7 Conclusion

Chapter 4: Metabolic Role of Hyperhomocysteinemia in the Etiology of Chronic Diseases

2 Homocysteine Metabolism

3 Hyperhomocysteinemia and Neurological Disorders

3.1 Stroke

3.2 Mild Cognitive Impairment (MCI), and Dementia

3.3 Parkinson's Disease (PD)

3.4 Epilepsy

4 Hyperhomocysteinemia and Cardiovascular Diseases

5 Hyperhomocysteinemia and Cancer

6 Conclusion

Chapter 5: B-Vitamins Attenuates Preliminary Steps of Hyperhomocysteinemia and Colorectal Cancer

2 Dietary and Non-dietary Risk Factors for Colorectal Cancer

3 B-Vitamins, Glutathione and Colorectal Cancer

4 Hyperhomocysteinemia and Colorectal Cancer

5 Conclusion

Chapter 6: Hyperhomocysteinemia, B-Vitamins, and Coronary Artery Disease Risk

2 Sulfur Metabolism and Pathogenesis of Coronary Artery Disease

3 Hyperhomocysteinemia and Coronary Artery Disease

4 B-Vitamins Therapy and CAD

Chapter 7: Potential Role of Hyperhomocysteinemia in Prediabetes Etiology and Pathology

2 B-vitamins, Oxidative Stress and Prediabetes Risk

3 Hyperhomocysteinemia and the Pathogenesis of Prediabetes and Type 2 Diabetes

4 Current Research

Chapter 8: Genetic Risk Factors in the Development of Hyperhomocysteinemia

Notes:

Print version record

2 Dietary Factors Contributed to Hyperhomocysteinemia

Other Format:

Print version Waly, Mostafa I. Nutritional Management and Metabolic Aspects of Hyperhomocysteinemia

ISBN:

9783030578398

3030578399

9783030578404

3030578402

9783030578411

3030578410

OCLC:

1245666405

Access Restriction:

Restricted for use by site license