Schizophrenia : evolution and synthesis / edited by Steven M. Silverstein, Bita Moghaddam, and Til Wykes ; program advisory committee, Anil K. Malhotra, John McGrath, Andreas Meyer-Lindenberg, Bita Moghaddam, Steven M. Silverstein, Til Wykes.

Format:

Book

Contributor:

Silverstein, Steven M., editor.

Moghaddam, Bita, editor.

Wykes, Til, editor.

Series:

Strüngmann Forum reports

Language:

English

Subjects (All):

Schizophrenia.

Schizophrenia--Etiology.

Clinical medicine--Decision making.

Clinical medicine.

Physical Description:

1 online resource (390 pages).

Place of Publication:

Cambridge, Massachusetts ; London, England : The MIT Press, [2013]

System Details:

text file

Summary:

Despite major advances in methodology and thousands of published studies every year, treatment outcomes in schizophrenia have not improved over the last 50 years. Moreover, we still lack strategies for prevention and we do not yet understand how the interaction of genetic, developmental, and environmental factors contribute to the disorder. In this book, leading researchers consider conceptual and technical obstacles to progress in understanding schizophrenia and suggest novel strategies for advancing research and treatment.

Contents:

1 Schizophrenia: The Nature of the Problems and the Need for Evolution and Synthesis in Our Approaches / Steven M. Silverstein Silverstein, Steven M., Bita Moghaddam Moghaddam, Bita, Til Wykes Wykes, Til 1

Heterogeneity

2 What Kind of a Thing Is Schizophrenia? Specific Causation and General Failure Modes / Angus W. MacDonald III MacDonald, Angus W. III 25

3 How the Diagnosis of Schizophrenia Impeded the Advance of Knowledge (and What to Do About It) / William T. Carpenter Jr. Carpenter, William T., Jr. 49

4 What Dimensions of Heterogeneity Are Relevant for Treatment Outcome? / Leanne M. Williams Williams, Leanne M., Chloe Gott Gott, Chloe 63

5 Which Aspects of Heterogeneity Are Useful to Translational Success? / Aiden Corvin Corvin, Aiden, Robert W. Buchanan Buchanan, Robert W., William T. Carpenter Jr. Carpenter, William T., Jr., James L. Kennedy Kennedy, James L., Matcheri S. Keshavan Keshavan, Matcheri S., Angus W. MacDonald III MacDonald, Angus W. III, Louis Sass Sass, Louis, Michèle Wessa Wessa, Michèle 77

Risk and Resilience

6 How Should Resilience Factors Be Incorporated in Treatment Development? / Peter B. Jones Jones, Peter B. 93

7 Insights into New Treatments for Early Psychosis from Genetic, Neurodevelopment, and Cognitive Neuroscience Research / Kristin S. Cadenhead Cadenhead, Kristin S., Camilo de la Fuente-Sandoval Fuente-Sandoval, Camilo de la 101

8 From Epidemiology to Mechanisms of Illness / John McGrath McGrath, John, Andreas Meyer-Lindenberg Meyer-Lindenberg, Andreas 127

9 How Can Risk and Resilience Factors Be Leveraged to Optimize Discovery Pathways? / Craig Morgan Morgan, Craig, Michael O'Donovan O'Donovan, Michael, Robert A. Bittner Bittner, Robert A., Kristin S. Cadenhead Cadenhead, Kristin S., Peter B. Jones Jones, Peter B., John McGrath McGrath, John, Steven M. Silverstein Silverstein, Steven M., Heike Tost Tost, Heike, Peter Uhlhaas Uhlhaas, Peter, Aristotle Voineskos Voineskos, Aristotle 137

Models

10 Human Cell Models for Schizophrenia / Ashley M. Wilson Wilson, Ashley M., Akira Sawa Sawa, Akira 167

11 How Can Animal Models Be Better Utilized? / Patricio O'Donnell O'Donnell, Patricio 183

12 How Can Computational Models Be Better Utilized for Understanding and Treating Schizophrenia? / Daniel Durstewitz Durstewitz, Daniel, Jeremy K. Seamans Seamans, Jeremy K. 195

13 How Can Models Be Better Utilized to Enhance Outcome? A Framework for Advancing the Use of Models in Schizophrenia / Kevin J. Mitchell Mitchell, Kevin J., Patricio O 'Donnell 'Donnell, Patricio O, Daniel Durstewitz Durstewitz, Daniel, André A. Fenton Fenton, André A., Jay A. Gingrich Gingrich, Jay A., Joshua A. Gordon Gordon, Joshua A., Wolfgang Kelsch Kelsch, Wolfgang, Bita Moghaddam Moghaddam, Bita, William A. Phillips Phillips, William A., Akira Sawa Sawa, Akira 209

Development and Treatment

14 Why Kraepelin Was Right: Schizophrenia as a Cognitive Disorder / René S. Kahn Kahn, René S. 227

15 What Will the Next Generation of Psychosocial Treatments Look Like? / Kim T. Mueser Mueser, Kim T. 235

16 Creative Solutions to Overcoming Barriers in Treatment Utilization: An International Perspective / Wulf Rössler Rössler, Wulf 261

17 What Is Necessary to Enhance Development and Utilization of Treatment? / Vera A. Morgan Morgan, Vera A., Richard Keefe Keefe, Richard, René S. Kahn Kahn, René S., Anil K. Malhotra Malhotra, Anil K., Andreas Meyer-Lindenberg Meyer-Lindenberg, Andreas, Kim T. Mueser Mueser, Kim T., Karoly Nikolich Nikolich, Karoly, Wulf Rössler Rössler, Wulf, William Spaulding Spaulding, William, Sharmili Sritharan Sritharan, Sharmili, Til Wykes Wykes, Til 273.

Notes:

OCLC-licensed vendor bibliographic record.

ISBN:

9781461952350

1461952352

9781306140652

130614065X

9780262314602

0262314606

OCLC:

863672798

Access Restriction:

Open Access Unrestricted online access