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Rethinking cancer : a new understanding for the post-genomics era / edited by Bernhard Strauss, Marta Bertolaso, Ingemar Ernberg, and Mina J. Bissell.
- Format:
- Book
- Series:
- Vienna Series in Theoretical Biology
- Vienna series in theoretical biology
- Language:
- English
- Subjects (All):
- Cancer--Genetic aspects.
- Cancer.
- Cancer--Treatment.
- Physical Description:
- 1 online resource (415 pages)
- Place of Publication:
- Cambridge, Massachusetts : The MIT Press, [2021]
- Summary:
- "Steps toward an explanatory paradigm for cancer that integrates its different levels of organization (molecular, genetic, etc.) and also integrates theoretical and experimental biology with oncology"-- Provided by publisher.
- Contents:
- Intro
- Series Page
- Title Page
- Copyright
- Table of Contents
- Series Foreword
- Preface
- 1. Introduction and Overview
- I. Redefining the Problem: The Theory Dimension of Cancer
- 2. The Search for Progress and a New Theory Framework in Cancer Research
- 3. Cancer as a System: Hard Lessons from Physics and a Way Forward
- II. The Systems Dimension of Cancer
- 4. The Logic of Cancer Treatment: Why It Is So Hard to Cure Cancer
- Treatment-Induced Progression, Hyper-Progression, and the Nietzsche Effect
- 5. The Cell Attractor Concept as a Tool to Advance Our Understanding of Cancer
- 6. Adaptation of Molecular Interaction Networks in Cancer Cells
- 7. The Role of Genomic Dark Matter in Cancer: Using AI to Shine a Light on It
- Why Cancer Genes Are Not the Whole Story
- III. The Time Dimension of Cancer
- 8. Darwinism, Not Mutationalism, for New Cancer Therapies
- 9. Cancer as a Reversion to an Ancestral Phenotype
- 10. Time and Timing in Oncology: What Therapy Scheduling Can Teach Us about Cancer Biology
- IV. The Micro-/Environment Dimension of Cancer
- 11. Tissue Tension Modulates Metabolism and Chromatin Organization to Promote Malignancy
- 12. Cancer Metabolism and Therapeutic Perspectives: Exploiting Acidic, Nutritional, and Oxidative Stresses
- 13. Corrupted Vascular Tumor Niches Confer Aggressiveness and Chemoresistance to Neoplastic Cells
- 14. Metastasis as a Tug of War between Cell Autonomy and Microenvironmental Control: Readdressing Unresolved Questions in Cancer Metastasis
- 15. Niche Reconstruction to Revert or Transcend the Cancer State
- V. What Next?
- Contributors
- Index.
- Notes:
- OCLC-licensed vendor bibliographic record.
- ISBN:
- 0-262-36208-2
- 0-262-36340-2
- OCLC:
- 1245670898
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