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Cyanobacteria : omics and manipulation / edited by Dmitry A. Los.
- Format:
- Book
- Language:
- English
- Subjects (All):
- Cyanobacteria.
- Physical Description:
- 1 online resource (264 pages)
- Edition:
- 1st ed.
- Place of Publication:
- Norfolk, UK : Caister Academic Press, [2017]
- Summary:
- Topics covered: The cyanobacterial core-genome with a focus on secondary metabolites; cyanobacterial evolution; genomics of NRPS/PKS biosynthetic gene clusters; RNA-seq based transcriptomic analysis of single cyanobacterial cells; transcriptomics of the responses: genes, sensors, and molecular triggers; transcriptomic and proteomic analysis of diurnal cycles in nitrogen-fixing cyanobacteria; proteomic analysis of post translational modifications; metabolic engineering and systems biology for free fatty acid production; isoprene production; ethanol production: impact of omics of the model organism Synechocystis on yield enhancement; engineering of alkane production; photoautotrophic polyhydroxyalkanoate production. This cutting-edge text will serve as a valuable resource for all those working in this field and is recommended for all microbiology libraries.
- Contents:
- Intro
- Contents
- Preface
- Current Books of Interest
- 1 The Cyanobacterial Core Genome: Global and Specific Features with a Focus on Secondary Metabolites
- Introduction
- Metagenome analysis and information in cyanobacterial research
- Recent advances in pangenome assignment
- Detection of core- and clade-specific functions via metagenome analysis
- General principles of secondary metabolite biosynthesis in cyanobacteria
- Main classes of secondary metabolites in cyanobacteria
- Secondary metabolite gene clusters in the cyanobacterial pangenome
- Conclusions
- Future trends and challenges
- 2 Genome-wide Analysis of Cyanobacterial Evolution: The Example of Synechococcus
- The origin of Synechococcus
- The genome and pan-genome of cyanobacteria
- Speciation in cyanobacteria
- Genome-scale reconstruction of evolutionary relationships: phylogenomics
- Conclusion
- Future trends
- 3 Genomics of NRPS/PKS Biosynthetic Gene Clusters in Cyanobacteria
- Genome mining for NRPS/PKS biosynthetic gene clusters
- Comparative genomics of biosynthetic gene clusters
- Biosynthetic gene clusters conservation
- From prediction to characterization
- Genomics from isolated strains versus metagenomics
- 4 RNA-seq Based Transcriptomic Analysis of Single Cyanobacterial Cells
- Quantitation of total RNA in single Synechocystis cells
- Single-cell RNA isolation
- Whole-transcriptome amplification
- Quality control
- RNA-seq analysis of single-cell transcriptome
- Verification of RNA-seq results
- Technical and biological significance
- Considerations and future trends
- 5 Transcriptomics of Cyanobacterial Stress Responses: Genes, Sensors and Molecular Triggers
- Heat stress and other abiotic stresses.
- Cold stress and other abiotic stresses
- Conclusions: Sensors and universal triggers of stress responses
- 6 Transcriptomic and Proteomic Analysis to Understand Systems-level Properties of Diurnal Cycles in Nitrogen-fixing Cyanobacteria
- Systems biology and proteomics
- Cyanobacterial proteomics
- Protein-protein interactions
- Growth of cyanobacteria in the light and dark
- Future research directions
- 7 Proteomic Analysis of Post Translational Modifications in Cyanobacteria
- PTMs and proteomic analysis of PTMs in cyanobacteria
- Challenge and perspectives in PTM proteomics of cyanobacteria
- 8 Metabolic Engineering and Systems Biology for Free Fatty Acid Production in Cyanobacteria
- Metabolic engineering of FFA production in cyanobacteria
- Systems biology for FFA production in cyanobacteria
- Conclusions and future trends
- 9 Terpene Hydrocarbons Production in Cyanobacteria
- Introduction: state of the art
- Perspective
- The process
- Solar-to-product energy conversion efficiency and photosynthetic productivity
- Principles of CO2 delivery and terpene hydrocarbons sequestration
- Efficacy of terpene hydrocarbons as biofuels
- Efficacy of alcohol molecules as biofuels
- 10 Ethanol Production in Cyanobacteria: Impact of Omics of the Model Organism Synechocystis on Yield Enhancement
- Ethanol production in cyanobacteria
- The construction of the pdc/adh cassette
- The origin of the pdc/adh gene cassette
- The Zymomonas mobilis (Zm) pyruvate decarboxylase
- The native ADH of Synechocystis
- The Zymomonas mobilis (Zm) ADH
- The effect of the ADH co-factor
- Some key issues with metabolic engineering of Synechocystis
- Strains and substrains and genomics of the cell factory Synechocystis.
- Proteomic analysis in response to ethanol
- Transcriptomic analysis in response to ethanol
- Modelling of metabolic flux in Synechocystis to enhance ethanol production
- Theoretical estimates of ethanol yields
- Towards industrial production of ethanol from cyanobacteria
- Conclusion and future trends
- 11 Engineering of Alkane Production in Cyanobacteria
- Alkane profiles in native cyanobacteria
- Molecular tools for genetic engineering of cyanobacteria
- Systems biology research on cyanobacterial alkanes
- Fatty acid production in engineered cyanobacteria
- Alkane production in engineered cyanobacteria
- Protein engineering for ADO
- 12 Photoautotrophic Polyhydroxyalkanoate Production in Cyanobacteria
- Cyanobacteria as platforms for biomass production
- Cyanobacteria are native PHA producers
- Engineering cyanobacteria for PHA production
- Index.
- Notes:
- Description based on print version record.
- ISBN:
- 1-910190-56-X
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