Behavioral and biochemical issues in substance abuse / Frank R. George, Doris Clouet, guest editors ; Barry Stimmel, editor.

Format:

Book

Contributor:

Clouet, Doris H.

George, Frank Richard.

Stimmel, Barry, 1939-

Language:

English

Subjects (All):

Substance abuse--Genetic aspects--Congresses.

Substance abuse.

Neuropsychopharmacology--Congresses.

Neuropsychopharmacology.

Physical Description:

1 online resource (260 p.)

Edition:

1st ed.

Place of Publication:

New York : Routledge, 1991.

Language Note:

English

Summary:

This excellent book is a concise yet thorough examination of the important and emerging field of the study of biological risk factors in drug abuse. Historically, drug abuse research has concentrated on the contributions of environmental and behavioral factors as the major influences on addiction. The revelatory studies in this volume examine the genetic contributions to drug taking behavior through the use of animal models, cellular experiments and human clinical studies. Behavioral and Biochemical Issues in Substance Abuse provides for the first time in one volume, up-to-date, easily digeste

Contents:

Cover; Half Title; Title Page; Copyright Page; Table of Contents; Editorial: Behavioral and Biochemical Genetic Issues in Substance Abuse; Genetic Selections for Nicotine and Cocaine Sensitivity in Mice; Where Are the mu Receptors That Mediate Opioid Analgesia? An Autoradiographic Study in the HAR and LAR Selection Lines; Behavioral and Neurochemical Studies in Diazepam-Sensitive and -Resistant Mice; Animal Models for the Study of Alcoholism: Utility of Selected Lines; Use of Recombinant Inbred Strains to Assess Vulnerability to Drug Abuse at the Genetic Level

The Use of Recombinant Inbred Strains to Study Mechanisms of Drug ActionProgress Towards the Development of Animal Models of Smoking-Related Behaviors; Is There a Common Biological Basis for Reinforcement from Alcohol and Other Drugs?; Genetic Determinants of Susceptibility to the Rewarding and Other Behavioral Actions of Cocaine; Issues Surrounding the Assessment of the Genetic Determinants of Drugs as Reinforcing Stimuli; Establishment of Drug Discrimination and Drug Reinforcement in Different Animal Strains: Some Methodological Issues

Biochemical Genetic Differences in Vulnerability to Drug Effects: Is Statistically Significant Always Physiologically Important and Vice Versa?Genetic Influences in Human Substance Abuse; Methodological Issues in Genetic Studies of Human Substance Abuse; The Use of Nonneuronal Cells as an In Vitro Model System for Studying the Genetic Component of Cellular Response to Opiates and Other Drugs of Abuse; Selective Guide to Current ReferenceSources on Topics Discussed in ThisVolume; Behavioral and Biochemical Issues in Substance Abuse

Notes:

"Has also been published as Journal of addictive diseases, volume 10, numbers 1/2, 1991"--T.p. verso.

Includes bibliographical references at the end of each chapters.

Description based on print version record.

ISBN:

1-317-83776-2

1-138-98775-1

1-315-82540-6

1-317-83777-0

9781315825403

OCLC:

88224