Turmeric and curcumin for neurodegenerative disease / Magisetty Obulesu.

Format:

Book

Author/Creator:

Obulesu, Magisetty.

Language:

English

Subjects (All):

Nervous system--Degeneration--Chemotherapy.

Nervous system.

Turmeric--Therapeutic use.

Turmeric.

Curcumin--Therapeutic use.

Curcumin.

Nanomedicine.

Nervous system--Degeneration.

Chemotherapy.

Genre:

Electronic books.

Physical Description:

1 online resource

Place of Publication:

[Place of publication not identified] : Academic Press, 2021.

System Details:

text file

Contents:

Part 1 Alzheimer's disease

1 Health benefits of turmeric: Emphasis on anticancer activity p. 3

Gun puffing p. 4

Curcumin p. 4

Anticancer efficacy of curcumin p. 5

Colorectal cancer p. 5

Renal, bone, and lung cancer p. 6

Blood and other cancers p. 6

Antioxidant and antiinflammatory activity p. 7

Noncurcuminoids p. 9

Turmerones p. 10

Elemenes p. 10

ß-Elemene p. 11

Furanodiene, furanodienone, curcumol, and calebin A p. 11

Conclusions and future perspectives p. 13

2 Turmeric products in Alzheimer's disease p. 19

Natural compounds p. 20

Curcumin p. 20

Volatile essential oils of curcumin p. 21

Studies on human subjects p. 22

Metal-chelation by curcumin p. 22

Antiamyloidogenic activity p. 22

Signaling p. 23

Curcumin analogs p. 24

Theracurmin p. 25

Shortcomings in therapeutic efficacy of curcumin p. 25

Conclusions and future perspectives p. 27

3 Curcumin in Alzheimer's disease diagnosis and treatment p. 35

Curcumin's influence on enzymes p. 37

Curcumin and resveratrol p. 37

Oxidative damage p. 39

Chemistry and metabolism p. 40

Inflammation p. 40

Curcumin in Alzheimer's disease diagnosis p. 40

Studies on humans p. 42

Amyloid interaction p. 42

Conclusions and future perspectives p. 43

4 Curcumin loaded drug delivery systems in the treatment of Alzheimer's disease p. 51

Curcumin p. 52

Tau inhibition p. 52

Challenges p. 53

Curcumin delivery systems p. 53

Polymeric nanoparticles p. 54

Poly(lactic-co-glycolic acid) p. 54

Surface modification p. 57

Chitosan p. 58

Micelles p. 59

Phytosomes p. 59

Lipid-based nanocarriers p. 60

Liposomes p. 61

Liquid crystalline nanocarriers p. 62

Solid lipid nanoparticles p. 62

Nanostructured lipid carriers p. 63

Magnetic nanoparticles p. 63

Theranostic approach of curcumin p. 64

Conclusions and future perspectives p. 64

Part 2 Parkinson's disease

5 Turmeric products in Parkinson's disease treatment p. 73

α-Synuclein p. 74

Therapeutics p. 74

Turmeric p. 75

Turmerone p. 75

Furanodiene p. 76

Curcumin p. 76

α-Synudein p. 76

Antioxidant activity p. 79

Curcumin against inflammation p. 79

Neuronal apoptosis p. 80

Curcumin analogs p. 80

Conclusions and future perspectives p. 81

6 Curcumin in Parkinson's disease treatment p. 89

Drugs p. 90

Polyphenols p. 90

α-Synuclein p. 91

Curcumin p. 92

Autophagy in Parkinson's disease p. 94

Curcumin analogs p. 94

Cyclocurcumin p. 95

Tetrahydrocurcumin p. 96

CNB-001 p. 97

Conclusions and future perspectives p. 98

7 Curcumin loaded drug delivery systems in Parkinson's disease p. 105

Blood-brain barrier p. 105

Curcumin p. 105

Challenges in curcumin's therapeutic efficacy p. 107

Drug delivery systems p. 107

Nanoformulations of curcumin p. 108

Polymeric nanoparticles p. 110

Micelles p. 110

Liposomes p. 111

Solid lipid nanoparticles p. 112

Surface functionalization p. 112

Conclusions and future perspectives p. 112

Part 3 Liver diseases

8 Turmeric products in liver disease treatment p. 123

Nonalcoholic fatty liver disease p. 124

Oxidative stress in liver diseases p. 125

Drugs p. 125

Natural products p. 126

Turmeric p. 126

Composition p. 126

Therapeutic efficacy of turmeric p. 127

Clinical trials p. 128

Turmeric products p. 129

Curcumin p. 129

Oxidative liver damage p. 130

Elemene p. 131

Conclusions and future perspectives p. 132

9 Curcumin in liver disease treatment p. 139

Drugs and liver p. 140

Curcumin p. 141

Curcumin counters liver damage p. 142

Protective efficacy of curcumin against liver-fibrosis and cirrhosis p. 143

Liver cirrhosis p. 144

Role of curcumin in nonalcoholic steatohepatitis p. 145

Role of curcumin In alcoholic liver disease p. 145

Role of curcumin against oxidative liver damage p. 145

Animal models p. 147

Conclusions and future perspectives p. 148

10 Curcumin loaded drug delivery systems in the treatment of liver diseases p. 155

Challenges in curcumin's therapeutic efficacy and strategies to overcome p. 156

Drug delivery systems p. 158

Cancer p. 159

Hepatic fibrosis p. 161

Nanoparticles targeted against liver inflammation p. 162

Conclusions and future perspectives p. 163.

Notes:

Includes index.

ISBN:

9780128224496

0128224495

OCLC:

1233252714

Access Restriction:

Restricted for use by site license.