Stem cells : scientific facts and fiction / Christine L. Mummery, Anja van de Stolpe, Bernard Roelen, Hans Clevers.

Format:

• Book

Contributor:

• Mummery, C. L. (Christine L.), 1953-
• Stolpe, Anja van de, 1956-
• Roelen, Bernard A. J., 1968-
• Clevers, Hans.

Language:

English

Subjects (All):

• Stem cells.

Genre:

• Electronic books.

Physical Description:

1 online resource

Edition:

Third edition.

Place of Publication:

London : Academic Press, 2020.

System Details:

text file

Contents:

• 1 The biology of the cell p. 1
• Organisms are composed of cells p. 2
• DNA, genes, and chromosomes p. 3
• How is the amount of mRNA regulated? p. 8
• Transcription factors p. 8
• From mRNA to a functional protein p. 9
• From DNA and proteins to a cell with a specific function p. 12
• Epigenetic regulation p. 12
• RNA interference p. 15
• DNA differences between genomes: mutation or variation? p. 15
• Diseases due to variations and genome mutations p. 16
• Dominant or recessive? p. 17
• DNA outside the nucleus: bacterial remains p. 18
• Cell lines and cell culture p. 19
• 2 Embryonic development p. 31
• Fertilization and early embryo development p. 39
• Sex cells and germ cell tumors p. 47
• 3 What are stem cells? p. 51
• What makes stem cells different from other cells? p. 52
• Totipotency, pluripotency, and embryonic stem cells p. 53
• Multipotency, unipotency, and adult stem cells p. 56
• Cell division and aging: the role of telomerase p. 59
• The relationship between cell division and differentiation: epigenetics p. 59
• Epigenetics in stem cells p. 60
• 4 Of mice and men: the history of embryonic stem cells p. 67
• How it all began: pluripotent cells in early embryos p. 67
• Mouse embryonal carcinoma cell lines p. 70
• Pluripotent cells in an early embryo p. 73
• Mouse embryonic stem cell lines p. 75
• Towards human embryonic stem cells p. 77
• On the road to stem cell therapy p. 85
• Biased interpretation? p. 87
• The future: stem cell transplantation as a clinical treatment p. 88
• Breakthrough of the decade in the 21st century: induced pluripotent stem cells p. 89
• 5 Origins and types of stem cells p. 95
• Pluripotent stem cells: past, present, and future p. 96
• Embryonal carcinoma or teratocarcinoma stem cells p. 96
• Embryonic stem cells p. 97
• Germline stem cells p. 101
• Induced pluripotent stem cells p. 102
• Multipotent (adult) stem cells p. 105
• Bone marrow p. 108
• Organoids: miniorgans in a dish p. 109
• Umbilical cord blood p. 110
• 6 Cloning: history and current applications p. 131
• Before Dolly p. 131
• Cloning Pets: Copy Cat and Snuppy p. 141
• Just imagine what could be p. 143
• Cloning domestic livestock p. 148
• Cloning Challenges p. 150
• Monkey cloning p. 152
• 7 Regenerative medicine: clinical applications of stem cells p. 159
• What is therapeutic cell transplantation? p. 162
• How many cells are needed for cell transplantation? p. 165
• Why will some diseases be treatable with stem cells in the future and others not? p. 167
• Loss of one cell type or more cell types p. 169
• Diabetes type I: an autoimmune disease p. 171
• Macular degeneration: the ideal disease? p. 172
• Deafness p. 173
• Spinal cord injury and multiple sclerosis: restoring demyelination p. 174
• Inherited and acquired diseases p. 178
• What are the best stem cells for transplantation? p. 180
• Can we combine gene therapy with stem cell transplantation? p. 185
• In what part of the body should stem cells be transplanted and where do they exert their effect? p. 189
• Which cell types will become available for cell transplantation? p. 191
• Adult stem cells p. 191
• Embryonic and induced pluripotent stem cells p. 194
• Transplantation of stem cells: where do we stand? p. 196
• Exosomes from stem and progenitor cells-a safer alternative? p. 201
• What are the risks associated with a stem cell transplantation? p. 201
• When will stem cells be rejected after transplantation? p. 204
• How does the body's immune system recognize a cell as "foreign"? p. 205
• Reverse rejection: graft-versus-host p. 208
• How to prevent rejection of a ceil transplant? p. 210
• Tissue engineering p. 214
• 8 Stem cells in veterinary medicine p. 221
• Treatment of family pets p. 222
• Tendon in the horse p. 223
• Osteoarthritis in dogs p. 225
• Induced pluripotent stem cells p. 226
• 9 Cardiomyocytes from stem cells: what can we do with them? p. 231
• The heart and cardiac repair p. 232
• Stem cells models of heart disease p. 234
• From pluripotent stem cells to cardiomyocytes p. 236
• 10 Adult stem cells: generation of self-organizing mini-organs in a dish p. 257
• Adult stem cells in internal organs p. 259
• Adult stem cells in the intestine p. 259
• Adult stem cells in muscle tissue p. 261
• What have we learnt about adult stem cells? p. 263
• The future: organoids to repair tissues and organs? p. 263
• 11 Stem cell tourism p. 275
• What is "stem cell tourism"? p. 275
• What is the difference between commercial stem cell "treatments/' early-phase medical intervention, and standard stem cell clinical practice? p. 278
• Perspective of the international society for stem cell research (ISSCR) p. 285
• 12 Cancer stem cells: where do they come from and where are they going? p. 299
• Cancer: observations and some questions to start with p. 300
• Introduction to stem cells and cancer p. 301
• A brief history of cancer stem cells p. 301
• The behavior of cancer cells: not all tumors and not all cells within a tumor, look the same p. 304
• A Darwinian view: evolution of a tumor p. 305
• Colon adenoma: a case in point for the role of an adult stem cell as the stem cell of origin p. 306
• Development of a colon adenoma p. 307
• When does a tumor become malignant and metastasize to different organs? p. 309
• Interaction between cancer cells and their environment leads to "phenotypic" heterogeneity p. 310
• How to become a cancer stem cell: epithelial mesenchymal transition p. 317
• Epithelial-mesenchymal transition and mesenchymal-epithelial transition: a renewed view on the role of cancer stem cells p. 318
• How could developmental signal transduction pathways become active in cancer cells? p. 319
• Cancer stem cells as circulating tumor cells p. 320
• The final step: initiation of metastatic growth p. 321
• A cancer stem cell: can it differentiate to another cell type? p. 321
• Cancer stem cells: development of new drugs to treat cancer? p. 323
• Conclusions and research challenges p. 326
• 13 Human stem cells for organs-on-chips: "clinical trials" without patients? p. 329
• What are organs-on-chips? p. 330
• New drugs and why would we need human organ and disease-on-chip models? p. 333
• Human organ-on-chip models: for which diseases? p. 337
• Human disease models as organ-on-chip: challenges p. 337
• Where are we now with organ-on-chip technology? p. 338
• Human stem cells as a critical component of organ-on-chip model systems p. 342
• Pluripotent or adult stem cells in the organ-on-chip? p. 342
• How to make stem cells "differentiate" to the right types of cells in the body p. 344
• Formation of functional tissues and organs using Organ-on-Chip technology p. 344
• What can "organs-on-chip" be used for? p. 346
• Model systems for drug toxicity screening p. 346
• Human disease models for drug target discovery and drug development: role for organs-on-chip p. 348
• 14 Stem cells for discovery of effective and safe new drugs p. 353
• Drug discovery: a short historical perspective p. 353
• Modern drug discovery p. 357
• Challenges and opportunities in drug discovery p. 358
• How is the safety of new drugs secured? p. 363
• 15 Patents, opportunities, and challenges: legal and intellectual property issues associated with stem cells p. 369
• Companies and alliances p. 371
• Patent issues: current intellectual property landscape p. 372
• Wisconsin Alumni Research Foundation p. 373
• Europe versus the United States p. 374
• More legal and ethical issues p. 380
• Privacy and ownership p. 381
• 16 Stem cell perspectives: a vision of the future p. 383
• Combining technologies: new human disease models for drug discovery p. 388
• Personalized medicine and safer drugs p. 390.

Notes:

Includes index.

ISBN:

• 9780128226773
• 0128226773

OCLC:

1232261159

Access Restriction:

Restricted for use by site license.