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Synthesis of bruceantin analogs and progress toward metal catalyzed intramolecular cyclizations of strained rings / Katherine E. Crocker.
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View online- Format:
- Book
- Thesis/Dissertation
- Author/Creator:
- Crocker, Katherine E., author.
- Language:
- English
- Subjects (All):
- Biomedical engineering.
- Biochemistry.
- Virology.
- Chemistry--Penn dissertations.
- Penn dissertations--Chemistry.
- Local Subjects:
- Biomedical engineering.
- Biochemistry.
- Virology.
- Chemistry--Penn dissertations.
- Penn dissertations--Chemistry.
- Genre:
- Academic theses.
- Physical Description:
- 1 online resource (241 pages)
- Contained In:
- Dissertations Abstracts International 82-04B.
- Place of Publication:
- [Philadelphia, Pennsylvania] : University of Pennsylvania ; Ann Arbor : ProQuest Dissertations & Theses, 2020.
- Language Note:
- English
- System Details:
- Mode of access: World Wide Web.
- text file
- Summary:
- The natural product bruceantin has long been studied for both its biological activity and its structural complexity. Attempts to synthesize more stable analogs for the development of inhibitors of γ-herpesviruses associated lymphomas are presented. In addition, a new method for the synthesis of the bridged bicyclic core structure of bruceantin using a homologous Pauson-Khand reaction of a bicyclo[2.1.0]pentane substrate is presented. Simple azabicyclo[2.1.0]pentane substrates were synthesized and studied for proof of concept of this approach in both rhodium- and palladium-catalyzed reactions. The palladium-mediated reaction led to the formation of enantiopure spirocyclic heterocycles.
- Notes:
- Source: Dissertations Abstracts International, Volume: 82-04, Section: B.
- Advisors: Winkler, Jeffrey D.; Committee members: Amos Smith III; Madeleine Joullie; Gary Molander; David Christianson.
- Department: Chemistry.
- Ph.D. University of Pennsylvania 2020.
- Local Notes:
- School code: 0175
- ISBN:
- 9798672164632
- Access Restriction:
- Restricted for use by site license.
- This item must not be sold to any third party vendors.
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