Protein biosynthesis interference in disease / Elena L. Paley.

Format:

Book

Author/Creator:

Paley, Elena L.

Language:

English

Subjects (All):

Proteins--Synthesis.

Proteins.

Biosynthesis.

Genre:

Electronic books.

Physical Description:

1 online resource (297 pages)

Place of Publication:

London : Academic Press, 2021.

System Details:

text file

Summary:

Protein Biosynthesis Interference in Disease offers a thorough discussion and overview of protein biosynthesis interference, its mechanisms of action, and influence over disease processes. This book examines the role of protein biosynthesis interference in Alzheimer's and other neurodegenerative conditions, cancer and inflammatory disorders, with specific attention paid to the biochemical dynamics of tryptamine, biogenic amines and aminoacyl-tRNA synthetases in these pathologies. Methods of regulating protein translation and interference mechanisms, including gene therapy, are presented, empowering biochemists, molecular biologists, disease researchers, and health professionals to understand the underlying factors of protein disease and improve patient outcomes.

Contents:

Front Cover

Protein Biosynthesis Interference in Disease

Copyright Page

Contents

Preface

1 Introduction

2 Tryptamine in the diet, human microbiome, tRNA aminoacylation-protein biosynthesis, host-microbiota metabolic interactions

2.1 Tryptamine interfere with the tRNA aminoacylation-protein biosynthesis in the model of neurodegeneration

2.2 Tryptamine interfere with serotonin binding to receptors in serotonin syndrome

2.3 Tryptamine in dysbiosis

3 Dimethyltryptamine, methyltryptamine, hallucinations and metals

4 Psychoactive effects and toxicity of tryptamine, N-methyltryptamine (NMT), and N, N-dimethyltryptamine (DMT): quantificat...

5 Tryptamine in renal pathologies and in pregnancy

6 Tryptophanyl-tRNA synthetase (TrpRS) inhibition or TrpRS gene (WARS) mutations and deletion result to TrpRS deficiency an...

7 Tryptamine in liver diseases and alcohol abuse

8 Tryptamine and tyramine in tobacco smoking

9 Tryptamine and other biogenic amines in human vaginal samples

10 Tryptamine and tryptophan in human fecal samples: diet alters tryptamine levels

11 Tryptamine in human noncataractous and cataractous eye lenses

12 Tryptamine toxicity in rats, adrenalectomy, toxicity prevention

13 Microorganisms: the natural producers of tryptamine in food

14 Human gut bacterial sequence associated with Alzheimer's disease and biogenic amines

15 Diseases, factors and conditions associated with Alzheimer's disease (AD) and dementia support a concept that AD is a wi...

15.1 Historical evolution and terminology from 1907 to contemporary

15.2 Senile plaques and neurofibrillary tangles in organs other than brain

15.3 Diseases, factors and conditions associated with Alzheimer's disease and dementia

16 Arterial hypertension is comorbidity in dementia and Alzheimer's disease, tryptamine in metabolic syndrome

17 Whole blood viscosity: biogenic amines, dementia and Alzheimer's disease

18 Tryptamine and aminoacyl-tRNAs in sleep-wake and circadian disruption

19 Senile plaques and/or neurofibrillary tangles in brain of non-demented individuals

20 Historical perspective and future research directions

20.1 On determining the most appropriate test cut-off values for Alzheimer's disease associated sequence (ADAS)-linked tryp...

20.2 Updated hypothesis of tryptamine-induced neurodegeneration: experimental and observational data

20.3 Validation studies and future experiments

20.4 Major challenges for new preclinical and clinical trials

20.5 Tryptamine physiological pathways: tryptamine is a ligand and agonist activating 5H, TAAR1, and AhR receptors

20.6 Linkage of present theory to other theories and the major pathological features of Alzheimer's disease

Notes:

Description based upon print version of record.

21 Tryptamine content and effects in human and animals.

Other Format:

Print version: Paley, Elena L. Protein Biosynthesis Interference in Disease

ISBN:

9780128234860

0128234865

9780128234853

0128234857

OCLC:

1202468402

Access Restriction:

Restricted for use by site license.